Differential effects of high-fat diet on glucose tolerance, food intake, and glucocorticoid regulation in male C57BL/6J and BALB/cJ mice.

The C57BL/6J strain of laboratory mice is a popular subject for studies of diet-induced obesity and diabetes given its propensity for developing obesity and glucose intolerance when placed on high-fat diet. High-fat diet leads to much lower weight gain in young adult BALB/cJ mice, which appear to be protected from many of the metabolic effects of high-fat diet observed in C57BL/6J mice. In this report, the effects of diet and timing of feeding on body weight, food intake, glucose tolerance, and stress-induced corticosterone and blood glucose responses were assessed in male C57BL/6J and BALB/cJ mice.

An investigation of a novel reusable radiochromic sheet for 2D dose measurement.

Purpose: Radiochromic film remains a useful and versatile clinical dosimetry tool. Current film options are single use. Here, we introduce a novel prototype two-dimensional (2D) radiochromic sheet, which optically clears naturally at room temperature after irradiation and can be reused.

Surprising lack of sensitivity of biochemical limitation of photosynthesis of nine tree species to open-air experimental warming and reduced rainfall in a southern boreal forest.

Photosynthetic biochemical limitation parameters (i.e., V , J and J :V ratio) are sensitive to temperature and water availability, but whether these parameters in cold climate species at biome ecotones are positively or negatively influenced by projected changes in global temperature and water availability remains uncertain.

Monte Carlo Modeling of Contemporary Intelligence Test (IQ) Factor Structure: Implications for IQ Assessment, Interpretation, and Theory.

Researchers continue to debate the constructs measured by commercial ability tests. Factor analytic investigations of these measures have been used to develop and refine widely adopted psychometric theories of intelligence particularly the Cattell-Horn-Carroll (CHC) model. Even so, this linkage may be problematic as many of these investigations examine a particular instrument in isolation and CHC model specification across tests and research teams has not been consistent.

Intensified vegetation water use under acid deposition.

Despite the important role vegetation plays in the global water cycle, the exact controls of vegetation water use, especially the role of soil biogeochemistry, remain elusive. In this study, we reveal a new mechanism of soil biogeochemical control of large-scale vegetation water use. Nitrate and sulfate deposition from fossil fuel burning have caused substantial soil acidification, leading to the leaching of soil base cations.

The impact of childhood maltreatment on adolescent gang involvement.

Background: A number of risk factors for gang involvement have been identified in the literature, such as victimization, poor parental monitoring, aggressive behavior, and affiliation with delinquent peers. However, few studies have examined the influence of maltreatment experiences during childhood on gang involvement later in adolescence.

Objective: This study examines how differential experiences of maltreatment might impact future gang involvement.

Evidence for Internal Desynchrony Caused by Circadian Clock Resetting.

Circadian disruption has been linked to markers for poor health outcomes in humans and animal models. What is it about circadian disruption that is problematic? One hypothesis is that phase resetting of the circadian system, which occurs in response to changes in environmental timing cues, leads to internal desynchrony within the organism. Internal desynchrony is understood as acute changes in phase relationships between biological rhythms from different cell groups, tissues, or organs within the body.

A Misuse of IQ Scores: Using the Dual Discrepancy/Consistency Model for Identifying Specific Learning Disabilities.

The purpose of this article is to describe the origins of patterns of strengths and weaknesses (PSW) methods for identifying specific learning disabilities (SLD) and to provide a comprehensive review of the assumptions and evidence supporting the most commonly-used PSW method in the United States: Dual Discrepancy/Consistency (DD/C). Given their use in determining whether students have access to special education and related services, it is important that any method used to identify SLD have supporting evidence. A review of the DD/C evidence indicates it cannot currently be classified as an evidence-based method for identifying individuals with a SLD.

A comparison of song-lyric and prose self-instruction procedures for increasing novel skills in children.

We compared the effects of the effects of self-instructions in the form of prose or song lyrics in the acquisition of gross motor tasks in 4 third-grade children. We taught participants 4 pairs of gross motor tasks, with one task in each pair taught with prose self-instructions and the other taught with song lyric self-instructions. Both self-instruction procedures were effective for teaching tasks; however, acquisition was quicker with song lyric self-instruction for 4 task pairs, acquisition was quicker with prose self-instruction for 3 task pairs; and similar for 1 task pair.

Effects of high fat diet and chronic circadian challenge on glucocorticoid regulation in C57BL/6J mice.

Both high-fat diet and chronic circadian disruption have been associated with increased incidence of obesity and type 2 diabetes in humans. Chronically elevated glucocorticoids, which have considerable impacts on physiological processes such as intermediary metabolism, inflammation, and fat metabolism, have also been implicated in insulin resistance associated with obesity and diabetes. In this study, the effects of high-fat diet (HFD) or chronic circadian challenge in C57BL/6J mice on basal and stress-induced corticosterone (CORT) and blood glucose levels were assessed.

North-south gradient of mesothelioma and asbestos consumption-production in the United States-Progresses since the 1st asbestos partial ban in 1973.

Background: Temporal trends and broad geographical distributions of asbestos use and the incidence of malignant mesothelioma (MM) in the US still need to be studied.

Methods: Data on asbestos consumption and production between 1900 and 2015 and MM mortality and incidence rates between 1975 and 2015 in the US were examined. Spatial distributions of MM mortality and incidence rates and their association with climate zone were analyzed.

Auxetic deformations and elliptic curves.

In materials science and engineering, auxetic behavior refers to deformations of flexible structures where stretching in some direction involves lateral widening, rather than lateral shrinking. We address the problem of detecting auxetic behavior for flexible periodic bar-and-joint frameworks. Currently, the only known algorithmic solution is based on the rather heavy machinery of fixed-dimension semi-definite programming.

Construct Validity of the WISC-V in Clinical Cases: Exploratory and Confirmatory Factor Analyses of the 10 Primary Subtests.

Independent exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) research with the Wechsler Intelligence Scale for Children-Fifth Edition (WISC-V) standardization sample has failed to provide support for the five group factors proposed by the publisher, but there have been no independent examinations of the WISC-V structure among clinical samples. The present study examined the latent structure of the 10 WISC-V primary subtests with a large ( = 2,512), bifurcated clinical sample (EFA, = 1,256; CFA, = 1,256). EFA did not support five factors as there were no salient subtest factor pattern coefficients on the fifth extracted factor.

Size-growth asymmetry is not consistently related to productivity across an eastern US temperate forest network.

Modeling and forecasting forests as carbon sinks require that we understand the primary factors affecting productivity. One factor thought to be positively related to stand productivity is the degree of asymmetry, or the slope of the relationship between tree size and biomass growth. Steeper slopes indicate disproportionate productivity of big trees relative to small trees.

Cognitive profile analysis in school psychology: History, issues, and continued concerns.

Intelligence testing remains a fixture in school psychology training and practice. Despite their popularity, the use of IQ tests is not without controversy and researchers have long debated how these measures should be interpreted with children and adolescents. A controversial aspect of this debate relates to the utility of cognitive profile analysis, a class of interpretive methods that encourage practitioners to make diagnostic decisions and/or treatment recommendations based on the strengths and weaknesses observed in ability score profiles.

PHA eludes macrophage suppression to activate CD8 T cells.

Tumors may include a high proportion of immune modulatory cells and molecules that restrain the anti-cancer response. Activation of T cells to eliminate cancer cells within the immune-suppressive tumor microenvironment remains a challenge. We have shown that C57BL/6 J peritoneal cell culture models features of macrophage-dense tumors as TCR ligation fails to activate T cells unless IFNγ is neutralized or iNOS is inhibited.

Behavioral Research with Planaria.

This article serves as a brief primer on planaria for behavior scientists. In the 1950s and 1960s, McConnell's planarian laboratory posited that conditioned behavior could transfer after regeneration, and through cannibalization of trained planaria. These studies, the responses, and replications have been collectively referred to as the "planarian controversy.

Catalytic linkage between caspase activity and proteostasis in Archaea.

The model haloarchaeon, Haloferax volcanii possess an extremely high, and highly specific, basal caspase activity in exponentially growing cells that closely resembles caspase-4. This activity is specifically inhibited by the pan-caspase inhibitor, z-VAD-FMK, and has no cross-reactivity with other known protease families. Although it is one of the dominant cellular proteolytic activities in exponentially growing H.

Development of a Distance-Based Effect Size Metric for Single-Case Research: Ratio of Distances.

This article describes the development of an effect size measure called Ratio of Distances (RD). The goal was to develop a measure of level change for single case experimental research that met several practical requirements: (a) the measure is adaptable to designs with varying numbers of observations per, and across, phases; (b) the measure is adaptable to situations in which slope does and does not exist; (c) the measure has no ceiling, as is the limitation with commonly used overlap-based measures of effect size; and (d) the measure is computationally transparent and easily computed using widely available analysis tools (e.g.

The NIH's slow response to the AIDS epidemic and the dismissal of Pasteur's contributions: Learning from history.

The National Institutes of Health's (NIH) slow response to the AIDS epidemic in the early 1980s led to deaths and missed opportunities to stop the spread of the disease. In addition, the NIH systematically diminished the contributions of the scientists at the Pasteur Institute who discovered HIV and produced a superior AIDS test. I analyze these events by applying three social theories to the global response to the epidemic.

Factors that predict murder defendants' competence to stand trial.

One hundred sixty-three homicide case files from The Center for Forensic Psychiatry in Ypsilanti, Michigan were examined for evidence of factors associated with the outcomes of Competency to Stand Trial (CST) evaluations. Of the socio-demographic, legal, and clinical factors investigated, only three were significant. Defendants with lower IQs were more likely to be found incompetent to stand trial, and those with more property crime arrests were more likely to be found competent to stand trial.

Periodic Auxetics: Structure and Design.

Materials science has adopted the term of auxetic behavior for structural deformations where stretching in some direction entails lateral widening, rather than lateral shrinking. Most studies, in the last three decades, have explored repetitive or cellular structures and used the notion of negative Poisson's ratio as the hallmark of auxetic behavior. However, no general auxetic principle has been established from this perspective.

Revisiting Carroll's survey of factor-analytic studies: Implications for the clinical assessment of intelligence.

[Correction Notice: An Erratum for this article was reported in Vol 30(8) of (see record 2018-37729-003). In the article "Revisiting Carroll's Survey of Factor-Analytic Studies: Implications for the Clinical Assessment of Intelligence," by Nicholas F. Benson, A.

Effects of urbanization on the population structure of freshwater turtles across the United States.

Landscape-scale alterations that accompany urbanization may negatively affect the population structure of wildlife species such as freshwater turtles. Changes to nesting sites and higher mortality rates due to vehicular collisions and increased predator populations may particularly affect immature turtles and mature female turtles. We hypothesized that the proportions of adult female and immature turtles in a population will negatively correlate with landscape urbanization.

Dosimetric and geometric characteristics of a small animal image-guided irradiator using 3D dosimetry/optical CT scanner.

Purpose: The precise dosimetric and geometric characteristics of small animal irradiators are essential to achieving reproducible dose delivery, especially in cases where image-guidance is utilized. Currently, radiochromic film is the established measurement tool used to evaluate beam characteristics for these systems. However, only 2D information can be acquired with film.