37,393 results match your criteria: "Rhinitis Allergic"
Eur J Pediatr
December 2024
Krefting Research Centre, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Box 424, 405 30, Gothenburg, Sweden.
Unlabelled: Atopic dermatitis, food allergy, allergic rhinitis, and asthma are among the most common diseases in childhood. They are heterogeneous diseases, can co-exist in their development, and manifest complex associations with other disorders and environmental and hereditary factors. Elucidating these intricacies by identifying clinically distinguishable groups and actionable risk factors will allow for better understanding of the diseases, which will enhance clinical management and benefit society and affected individuals and families.
View Article and Find Full Text PDFMedicine (Baltimore)
December 2024
Acupuncture and Massage College of Changchun University of Traditional Chinese Medicine, Changchun, China.
Background: More and more studies have shown that Chinese medicine can effectively and safely treat allergic rhinitis (AR) in children. This meta-analysis aims to compare the efficacy and safety differences between conventional therapy and the Chinese herbal medicine Cang-Er-Zi-San (CEZS) from an evidence-based perspective, and guide the clinical treatment of pediatric AR.
Methods: This study aims to compare the effects of intervention with traditional Chinese medicine formula CEZS on the clinical symptoms of pediatric AR, determine the effectiveness and safety of CEZS in treating pediatric AR, and obtain high-quality clinical evidence.
Front Immunol
December 2024
Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, China.
Front Immunol
December 2024
Department of Hygiene, Epidemiology and Ergonomics, Medical University of Bialystok, Bialystok, Poland.
Recent studies indicate that oxidative/nitrosative stress is involved in the pathogenesis of asthma, allergic rhinitis, atopic dermatitis, and urticaria. The article aimed to review the latest literature on disruptions in redox homeostasis and protein glycation in allergy patients. It has been shown that enzymatic and non-enzymatic antioxidant systems are impaired in allergic conditions, which increases cell susceptibility to oxidative damage.
View Article and Find Full Text PDFEur J Med Res
December 2024
Fuzhou Second Hospital, Fuzhou, China.
Objectives: This study endeavors to comprehensively assess the efficacy of a multimodal therapy protocol in the management and treatment of allergic rhinitis.
Methods: This study employed a randomized controlled trial design, enrolling a total of 100 patients, who were randomly assigned to either the experimental group (receiving multimodal therapy) or the control group (receiving standard treatment), with 50 patients in each group. All enrolled patients were diagnosed based on standard guidelines for allergic rhinitis.
J Bras Pneumol
December 2024
. Programa de Pós-Graduação em Epidemiologia, Universidade Federal de Pelotas, Pelotas (RS), Brasil.
Objectives: To estimate the prevalence of allergic rhinitis (AR), atopic dermatitis (AD), and wheezing, and to describe their patterns of co-occurrence according to different characteristics in adolescence and early adulthood.
Methods: Cross-sectional analyses from the 15-year and 22-year follow-ups of the 1993 Pelotas (Brazil) Birth Cohort. The outcomes were assessed based on self-reported data, and the patterns of co-occurrence were determined using cluster analysis.
Immun Inflamm Dis
December 2024
Medical Affairs and Clinical Department, LETI Pharma S.L.U., Madrid, Spain.
Background: Efficacy of allergen immunotherapy is dose-dependent; however, high doses of allergen may imply a greater risk of adverse reactions.
Objective: To assess the safety and tolerability of subcutaneous immunotherapy (SCIT) with mixtures of mite allergen extracts, Dermatophagoides pteronyssinus/Blomia tropicalis (Dpt/Bt) and Dermatophagoides pteronyssinus/Lepidoglyphus destructor (Dpt/Ld) at maximum concentrations, in adult patients with allergic rhinitis or rhinoconjunctivitis, and controlled allergic asthma due to a clinically relevant sensitisation to these mites.
Methods: An open-label, noncontrolled, nonrandomised, phase IIb clinical trial was carried out in three hospitals in Spain between September 2014 and May 2018.
J Investig Allergol Clin Immunol
December 2024
SEAIC Food Committee, Eosinophilic Esophagitis Group, Spain.
Eosinophilic esophagitis (EoE) is a chronic allergic condition affecting the esophagus and driven by food antigens. Many individuals diagnosed with EoE have other allergic conditions, such as food allergy, asthma, allergic rhinitis, and atopic dermatitis. The clinical goals of therapy in EoE include symptomatic, histologic, and endoscopic remission.
View Article and Find Full Text PDFAllergy
December 2024
Division of Dermatology, Department of Medicine, Queen's University, Kingston, Ontario, Canada.
In this review, we provide an overview of food allergy genetics and epigenetics aimed at clinicians and researchers. This includes a brief review of the current understanding of genetic and epigenetic mechanisms, inheritance of food allergy, as well as a discussion of advantages and limitations of the different types of studies in genetic research. We specifically focus on the results of genome-wide association studies in food allergy, which have identified 16 genetic variants that reach genome-wide significance, many of which overlap with other allergic diseases, including asthma, atopic dermatitis, and allergic rhinitis.
View Article and Find Full Text PDFStem Cell Res Ther
December 2024
Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Introduction: Sublingual immunotherapy (SLIT) is an effective and injection-free route for allergen-specific immunotherapy (AIT). Mesenchymal stromal/stem cell (MSC)-derived exosomes (Exo) has been identified as a novel delivery platform with immunomodulatory capacities. In addition, targeting agents such as aptamers (Apt) have been extensively used for specific delivery approaches such as direct delivery of allergen formulations to dendritic cells (DC) to improve the efficacy of specific immunotherapy.
View Article and Find Full Text PDFBiochem Biophys Res Commun
November 2024
Department of Infectious Disease Control, Faculty of Medicine, Oita University, Oita, 879-5593, Japan; Research Center for GLOBAL and LOCAL Infectious Diseases, Oita University, Oita, 879-5593, Japan. Electronic address:
Lipid mediator, palmitoylethanolamide (PEA) has recently attracted attention as a potential therapeutic option for various inflammatory autoimmune diseases. It has been reported that PEA exerts an inhibitory effect on inflammation triggered by PRRs, particularly Toll-like receptors expressed on myeloid antigen-presenting cells. However, the precise role of PEA in T cell development and function has not yet been elucidated.
View Article and Find Full Text PDFFront Pharmacol
December 2024
Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, Lodz, Poland.
Patients' collaboration with healthcare providers, along with their individual dedication to follow medical recommendations, is a crucial component of effective therapy in chronic diseases. If a patient fails to fill their prescription, administers the medication improperly in terms of method and/or dosage, misses follow-up visits, or discontinues the treatment for any reason, these lapses can adversely affect disease management, impairing the effectiveness of symptom relief and prevention of progression and complications. A comparable situation pertains to allergic diseases, which require long-term and consistent treatment to achieve symptom alleviation and control.
View Article and Find Full Text PDFAnn Otol Rhinol Laryngol
December 2024
Department of Otorhinolaryngology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Objective: Soluble fibrinogen-like protein 2 (sFGL2) may be involved in the pathology and progression of allergic rhinitis (AR) through regulating T-helper (Th)2 cell response. This study aimed to explore the ability of sFGL2 to estimate outcomes in AR patients.
Methods: sFGL2 was detected in the serum sample of 119 AR patients at baseline and 20 healthy controls (HCs) after enrollment by enzyme-linked immunosorbent assay.
J Clin Med
December 2024
Department of Oral Public Health, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, The Netherlands.
Periodontitis (PD) patients frequently suffer from comorbidities, necessitating increased attention to disease management and monitoring. The aim of this study is to describe the prevalence and patterns of comorbidities among patients with PD in a private periodontal referral practice. This study involved 3171 adults with PD.
View Article and Find Full Text PDFJ Clin Med
November 2024
Department of Clinical Immunology, Faculty of Medicine, Wroclaw Medical University, 50-367 Wrocław, Poland.
Allergic diseases triggered by airborne allergens such as allergic rhinitis and conjunctivitis are increasingly prevalent, posing significant challenges for both patients and healthcare systems. Assessing the efficacy of allergen immunotherapy and other anti-allergic treatments requires precise and reproducible methods. Allergen exposure chambers (AECs) have emerged as advanced tools for evaluating clinical outcomes, offering controlled conditions that address many limitations of traditional field-based studies.
View Article and Find Full Text PDFInt J Mol Sci
November 2024
Department of Medical Sciences and Public Health, University of Cagliari, 09124 Monserrato, Italy.
Mast cells are immune system cells with the most disparate functions, but are also among the least understood. Mast cells are implicated in several known pathological processes, tissue homeostasis, and wound repair. However, they owe their notoriety to allergic diseases, of which they represent the effector cell par excellence.
View Article and Find Full Text PDFNutrients
November 2024
Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.
Allergic Rhinitis (AR) is an atopic disease affecting the upper airways of predisposed subjects exposed to aeroallergens. This study evaluates the effects of a mix of specific probiotics ( PBS066, LRH020, BB077, and subsp. BLG240) on symptoms and fecal microbiota modulation in subjects with AR.
View Article and Find Full Text PDFBMC Pulm Med
December 2024
Department of respiratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Background: Dupilumab inhibiting the signaling of interleukin(IL)-4 and IL-13 was recommended for the treatment of severe asthma in children ≥ 6 years old according to the Global Initiative for Asthma (GINA,2024).This study aimed to analyse the efficacy and safety of dupilumab in paediatric patients with moderate-to-severe asthma and comorbid type 2 inflammatory disease in a real-world population.
Methods: We evaluated the medical records of paediatric patients with moderate-to-severe asthma and comorbid type 2 inflammatory diseases, such as atopic dermatitis (AD) and allergic rhinitis (AR), receiving dupilumab treatment.
Allergy Asthma Clin Immunol
December 2024
Division of Allergy & Immunology, Department of Medicine, Queen's University, Kingston, ON, Canada.
Allergen immunotherapy (AIT) is a potentially disease-modifying therapy that is effective for the treatment of allergic rhinitis/conjunctivitis, allergic asthma and stinging insect hypersensitivity. The decision to proceed with AIT should be made on a case-by-case basis, based on a comprehensive evaluation of the patient, allergy testing and a thorough discussion with the patient about treatment goals, risks vs. benefits, and long-term commitment to the treatment plan.
View Article and Find Full Text PDFImmunol Res
December 2024
Disciplina de Imunologia Clínica, Faculdade de Medicina, Centro Universitário FMABC, Avenida Lauro Gomes, 2000, Santo Andre, SP, 09060.870, Brazil.
Selective IgM deficiency (SIgMD) has recently been included in the inborn errors of immunity classification. SIgMD has conflicting diagnostic criteria and diverse clinical and immunological findings. We aimed to assess the clinical and laboratory profiles of patients with SIgMD and to compare the data of patients diagnosed using two inclusion criteria.
View Article and Find Full Text PDFImmun Inflamm Dis
December 2024
Department of General Practice Medicine, Third Affiliated Hospital of Shenzhen University, Shenzhen, China.
Background: Eosinophils have been acknowledged to be involved in the induction of numerous inflammatory disorders. There is still a lack of knowledge about whether eosinophils play a role in immune regulation. The aim of this study is to uncover the immune regulatory functions of eosinophils.
View Article and Find Full Text PDFJ Dtsch Dermatol Ges
December 2024
Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.
Background And Objectives: Studies have identified increased risks of pregnancy complications in expectant mothers with atopic dermatitis (AD). However, the associations between maternal AD and adverse pregnancy or offspring outcomes in Asians remain unexplored. Our aim was to investigate the relationship between maternal AD and adverse pregnancy and offspring outcomes in Taiwan.
View Article and Find Full Text PDFLancet Reg Health Eur
January 2025
Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
J Assoc Physicians India
December 2024
Professor and HOD, Department of General Medicine, Deben Mahata Government Medical College and Hospital, Purulia, West Bengal, India, Corresponding Author.
Allergy is an important public health disorder. Common allergic disorders include asthma, rhinitis, conjunctivitis, atopic eczema, contact dermatitis, and food and drug allergies. In this article, allergic disorders are discussed comprehensively, along with their epidemiological trends, quality of care, and barriers in management.
View Article and Find Full Text PDF