Developmental stages of tertiary lymphoid tissue reflect local injury and inflammation in mouse and human kidneys.

Tertiary lymphoid tissues (TLTs) are inducible ectopic lymphoid tissues in chronic inflammatory states and function as sites of priming local immune responses. We previously demonstrated that aged but not young mice exhibited multiple TLTs after acute kidney injury and that TLTs were also detected in human aged and diseased kidneys. However, the forms of progression and the implication for kidney injury remain unclear.

Influence of Elevated Intra-abdominal Pressure on Suture Tension Dynamics in a Porcine Model.

Background: Inadequate suture tension is a risk factor for the failure of laparotomy closure. Suture tension dynamics in the abdominal wall are still obscure due to the lack of measuring devices. To answer the questions if intra-abdominal hypertension (IAH) influences suture tension in midline laparotomies and if IAH leads to a permanent loss of suture tension, microsensors were applied in a porcine model of IAH.

Intravascular volume depletion in a 24-hour porcine model of intra-abdominal hypertension.

Background: The purpose of the study was to examine hemodynamic parameters and intravascular volume in a porcine model in the presence of intra-abdominal hypertension (IAH) lasting for 24 hours.

Methods: Twelve pigs (52.5 +/- 4.