17,000 results match your criteria: "Rhabdomyosarcoma"
Cancer Med
October 2024
Department of Pediatric Hematology and Oncology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Background: Rhabdomyosarcoma (RMS) is a rare malignant soft tissue sarcoma (STS), accounting for almost 50% of pediatric STSs. Due to its heterogeneity, RMS presents challenges in diagnosis and treatment, with prognosis varying depending on multiple factors. Tumors localized in the other site (OTH)-including the paraspinal, perianal, thoracic, abdominal, pelvic, and perineal regions-are generally classified as unfavorable.
View Article and Find Full Text PDFInt J Surg Case Rep
December 2024
University of Tunis El Manar, Tunis Faculty of Medicine, 1007, Tunisia; Department of Orthopedic Surgery, Hospital Mongi Slim La Marsa, Tunisia.
Introduction And Importance: Desmoid-type fibromatosis is an uncommon tumor characterized by its local invasiveness, with shoulder involvement being notably infrequent. The optimal treatment strategy for this tumor remains a topic of ongoing debate.
Case Presentation: A 47-year-old Tunisian woman with a history of hypothyroidism, presented with pain and swelling in her left shoulder for a year.
Cancers (Basel)
October 2024
Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Biomolecules
October 2024
Laboratory of Experimental Oncology, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
Pediatric sarcomas present a significant challenge in oncology. There is an urgent need for improved therapeutic strategies for high-risk patients and better management of long-term side effects for those who survive the disease. Liquid biopsy is emerging as a promising tool to optimize treatment in these patients by offering non-invasive, repeatable assessments of disease status.
View Article and Find Full Text PDFOncogene
October 2024
Medical Scientist Training Program, University of Colorado Anschutz Medical Campus (UC-AMC), Aurora, CO, USA.
Rhabdomyosarcoma (RMS), a malignancy of impaired myogenic differentiation, is the most common soft tissue pediatric cancer. PAX3-FOXO1 oncofusions drive the majority of the clinically more aggressive fusion-positive rhabdomyosarcoma (FP-RMS). Recent studies have established an epigenetic basis for PAX3-FOXO1-driven oncogenic processes.
View Article and Find Full Text PDFPract Radiat Oncol
October 2024
Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, Tennessee.
Purpose: Despite the urgent need for improved outcomes in patients with metastatic Ewing sarcoma (EWS) and rhabdomyosarcoma (RMS), it is unknown how to best approach metastatic-site radiation therapy for these patients and whether such treatment provides a significant oncologic benefit that outweighs the toxicities.
Methods And Materials: We gathered a panel of pediatric radiation oncologists from academic hospitals to identify and discuss current controversies regarding the role of radiation in the management of metastatic EWS and RMS. The panel reviewed existing clinical data and ongoing trials to address 5 key questions: (1) the role of whole lung irradiation (WLI) in treating lung metastases; (2) the number of metastatic sites warranting radiation therapy and the radicality of such an approach; (3) radiation techniques, including stereotactic body radiation therapy (SBRT); (4) the timing of metastatic-site radiation therapy; and (5) the utility of metastatic-site radiation therapy for relapsed metastatic disease.
J Med Imaging Radiat Oncol
October 2024
Radiation Oncology Network, Western Sydney Local Health District, Sydney, New South Wales, Australia.
Introduction: Paediatric cancers are rare, and most children requiring radiation therapy receive external beam radiation (EBRT). Although EBRT may offer organ preservation compared to surgery, it can be associated with significant late effects. Image-guided brachytherapy is a highly specialised technique offering both organ preservation and dose conformity to minimise late toxicity.
View Article and Find Full Text PDFCureus
September 2024
Department of Pathology, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, JPN.
Alveolar rhabdomyosarcoma (ARMS) is a malignant tumor with skeletal muscle differentiation that usually occurs in soft tissues of the extremities or trunk. To date, only a few cases of primary gastric ARMS have been reported. Herein, we describe a case of ARMS in a man in his 80s and present a literature review.
View Article and Find Full Text PDFTransl Androl Urol
September 2024
Division of Urology, Department of Surgery, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Background: Embryonal rhabdomyosarcoma (ERMS) of the prostate is a rare and aggressive malignant tumor in adults with a poor prognosis in general. The main presenting symptoms are dysuria and acute urinary retention. Prostate ERMS is easily misdiagnosed, which leads to delays in treatment.
View Article and Find Full Text PDFJ Med Imaging Radiat Oncol
October 2024
Perth Children's Hospital, Nedlands, Australia, Australia.
Limb-sparing surgery and amputation are common surgical techniques used to achieve local tumour control in childhood primary bone and soft tissue malignancy of the limbs. The interpretation of post-operative limb imaging in these frequently complex cases is assisted by knowledge of the surgical techniques employed. This review discusses the rationale underpinning the most common surgical techniques used for these patients as well as their expected post-operative imaging appearance and complications.
View Article and Find Full Text PDFTop Companion Anim Med
December 2024
Laboratory of Veterinary Pathology and Forensic, College of Agronomy and Veterinary Medicine (FAV), University of Brasília (UnB), Via L4 Norte, Asa Norte, Federal District, 70636-200, Brazil; Graduate Program in Animal Sciences, University of Brasília (UnB), ICC Central, Brasilia, Federal District, 70910-970, Brazil; Veterinary Teaching Hospital, College of Agronomy and Veterinary Medicine (FAV), University of Brasília (UnB), Via L4 Norte, Asa Norte, Federal District, 70636-200, Brazil. Electronic address:
Rhabdomyosarcomas (RBMs) are rare neoplasms arising from striated muscle tissues in domestic animals and are exceptionally uncommon, affecting the heart of domestic cats. A case of cardiac embryonal RBM was detected in a two-year-old female domestic shorthair cat. The cat exhibited dyspnea, anorexia, pericardial and pleural effusions, ultimately succumbing to severe respiratory arrest.
View Article and Find Full Text PDFAm J Dermatopathol
November 2024
Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY.
J Cancer Res Ther
July 2024
Department of Radiation Oncology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Objective: The current treatment of pediatric non-rhabdomyosarcoma soft tissue sarcomas (NRSTS) is a multimodal risk-based approach. Today, smaller fields and lower doses of radiotherapy (RT) have become standard. In this study, it was aimed to evaluate the treatment outcomes and toxicity profile in children with NRSTS that received RT as a part of multimodal therapy.
View Article and Find Full Text PDFThe authors wish to make corrections to the authorship and title of [...
View Article and Find Full Text PDFHead Neck Pathol
October 2024
Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd, Taipei City, 112201, Taiwan.
Mast cell sarcoma (MCS) is an extremely rare and aggressive malignancy primarily affecting bones, with limited literature associating it with neuroendocrine marker expression. This report presents a rare case of MCS arising in the maxillary sinus and gingiva. A 74-year-old man presented with a progressively enlarging ulcer on the right-sided upper gingiva.
View Article and Find Full Text PDFCancer Med
October 2024
Division of Cell Biology, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, South Africa.
Background: The highly homologous T-box transcription factors TBX2 and TBX3 are critical for embryonic development, and their overexpression in postnatal tissues contributes to a wide range of malignancies, including melanoma and rhabdomyosarcoma. Importantly, when TBX2 and TBX3 are depleted in cancers where they are overexpressed, the malignant phenotype is inhibited, and they have therefore been regarded as druggable targets. However, the time and costs associated with de novo drug development are challenging and result in drugs that are costly, especially for patients in low- and middle-income countries.
View Article and Find Full Text PDFInt Cancer Conf J
October 2024
Department of Radiation Oncology, Hyogo Ion Beam Medical Center Kobe Proton Center, 1-6-8 Minatojima Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047 Japan.
Rev Esp Cardiol (Engl Ed)
October 2024
Service de Cardiologie et Maladies Vasculaires, CHU de Rennes, Rennes, France. Electronic address:
BMJ Open
October 2024
Children's Hospital, University of Cologne, Cologne, Germany.
Background: Metronomic chemotherapy ('less is more, regularly') could be an alternative to the maximum tolerated dose ('the more, the better') in the chemotherapeutic cancer treatment of high-risk malignant solid extracranial tumours in children or young adults.
Objective: To evaluate the efficacy of metronomic chemotherapy compared with placebo or stop treatment in paediatric patients with extracranial malignant solid tumours.
Methods: We searched the databases MEDLINE and CENTRAL on 8 September 2023 and included randomised clinical trials (RCTs).
J Surg Case Rep
October 2024
Thoracic Surgery, Discipline of Surgery, Faculty of Medicine, Memorial University of Newfoundland, 300 Prince Philip Drive, St. John's, NL A1B 3V6, Canada.
bioRxiv
September 2024
The Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa Hospital, Smyth Road, Ottawa, ON., K1H 8L6.
J Exp Clin Cancer Res
October 2024
Hematology/Oncology and Cell and Gene Therapy Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Histopathology
October 2024
Department of Pathology and Laboratory Medicine, Diagnostic Institute, Cleveland Clinic, Cleveland, OH, USA.
Pediatr Blood Cancer
January 2025
Department of Pediatric Haemato-Oncology, Tata Medical Center, Kolkata, India.