Antiplasmodial Oleanane Triterpenoids from Root Bark.

Phytochemical investigation of the -BuOH extract of the roots of Sc. Elliot (Combretaceae) led to the isolation and identification of 10 oleanane triterpenoids (-), among which six new compounds, i.e.

Bioassay-guided isolation of antiplasmodial and antimicrobial constituents from the roots of Terminalia albida.

Ethnopharmacological Relevance: Terminalia albida (Combretaceae), widely used in Guinean traditional medicine, showed promising activity against Plasmodium falciparum and Candida albicans in previous studies. Bioassay-guided fractionation was carried out in order to isolate the compounds responsible for these activities.

Materials And Methods: Fractionation and isolation were performed by flash chromatography, followed by semi-preparative HPLC-DAD-MS.

Antimicrobial investigation of ethnobotanically selected guinean plant species.

Ethnopharmacological Relevance: In Guinea, medicinal plants play an important role in the management of infectious diseases including urinary disorders, skin diseases and oral diseases. This study was carried out to collect medicinal plant species employed for the treatment of these diseases and to investigate their antimicrobial potential.

Materials And Methods: Based on an ethnobotanical investigation carried out in three Guinean regions, 74 traditional healers and 28 herbalists were interviewed and medicinal plants were collected.

Prevalence, management and ethnobotanical investigation of hypertension in two Guinean urban districts.

Ethnopharmacological Relevance: Hypertension is an important public health challenge in low- and middle-income countries, and in many African countries including Guinea medicinal plants are still widely used for its treatment.

Materials And Methods: The objective of this study was to determine the prevalence of hypertension in two Guinean urban districts (Pounthioun and Dowsare), to describe its management and to collect information on traditional herbal remedies. A total of 316 participants entered the study, 28.

Biological and Phytochemical Investigations on , a Plant Traditionally Used as Antimalarial in Guinea.

is widely used as antimalarial in Guinean traditional medicine. Leaf extracts of the plant were tested for their in vitro antiprotozoal activity against and the chloroquine-sensitive Ghana strain of along with their cytotoxicity on MRC-5 cells. The methanolic extract showed the strongest antiprotozoal activity against (IC 4 g/ml), a good activity against (IC 13 g/ml), and a moderate activity against (IC 31 g/ml) along with an IC on human MRC-5 cells of 32 g/ml.

Antiplasmodial activity of Mezoneuron benthamianum leaves and identification of its active constituents.

Ethnopharmacological Relevance: Decoctions of the leaves of M. benthamianum Baill. are used by traditional healers in Guinea to treat malaria and this use was validated by a preliminary clinical assay.

Cyclopeptide Alkaloids from Hymenocardia acida.

Four cyclopeptide alkaloids (1-4) were isolated from the root bark of Hymenocardia acida by means of semipreparative HPLC with DAD and ESIMS detection and conventional separation methods. Structure elucidation was performed by spectroscopic means. In addition to the known compound hymenocardine (1), three other alkaloids were isolated for the first time from a natural source.

The malaria co-infection challenge: An investigation into the antimicrobial activity of selected Guinean medicinal plants.

Ethnopharmacological Relevance: In sub-Saharan Africa, concomitant occurrence of malaria and invasive infections with micro-organisms such as Gram-positive Staphylococcus aureus, Gram-negative Escherichia coli and yeasts or fungi such as Candida albicans and Aspergillus fumigatus is common. Non-tuberculous mycobacteriosis caused by Mycobacterium chelonae has been recognized as a pulmonary pathogen with increasing frequency without effective therapy. Although less important, the high incidence of Trichophyton rubrum infections along with its ability to evade host defense mechanisms, accounts for the high prevalence of infections with this dermatophyte.

Ethnobotanical survey on medicinal plants used by Guinean traditional healers in the treatment of malaria.

Ethnopharmacological Relevance: The objective of the present study was to collect and document information on herbal remedies traditionally used for the treatment of malaria in Guinea.

Materials And Methods: The survey was carried out from May 2008 to September 2010 and targeted traditional medical practitioners and herbalists. The questionnaire and oral interviews were based on the standardized model which was prepared by the "Centre de Recherche et de Valorisation des Plantes Médicinales (CRVPM) - Dubréka".

Management of diabetes in Guinean traditional medicine: an ethnobotanical investigation in the coastal lowlands.

Ethnopharmacological Relevance: This survey was carried out in the coastal lowlands of Guinea-Conakry in order to make an inventory of plants used by traditional healers, herbalists and diabetic patients for the management of diabetes mellitus.

Materials And Methods: Frequent ethnomedical and ethnobotanical investigations were conducted from June 2008 to December 2009 in Conakry, Kindia, Forécariah, Dubréka, Boke, Fria and Boffa. It is a cross-sectional survey and data collection is based on the interactive method.