DNA barcoding of invasive Gambusia holbrooki Girard, 1859 and Atherina boyeri Risso, 1810 inhabiting Upper Euphrates River Basin, Türkiye.

The main contributor to Türkiye's abundant freshwater fish biodiversity is its geographic location. This fauna consists of endemic, native, and non-native fish species. The introduction of Gambusia holbrooki Girard, 1859 to Lake Amik in the 1920s for the biological control of malaria was the first introduction of nonnative species to Türkiye.

Bacteriophage-based live bacteria detection for rapid infection diagnosis.

Bacterial bloodstream infections cause high morbidity and mortality. Although bacteria can be detected by various methods, culture methods are often used for the detection of live, accurate, reproducible, and selective bacterial identification. However, the culture method is time-consuming, and clinicians often start treatment immediately due to the long determination time.

Quantitative determination of leptin hormone using gold nanoparticle-based lateral flow assay.

A lateral flow assay (LFA) has been developed that can be used in point-of-care (PoC) use for the sensitive determination of leptin hormone. The limit of detection value was 0.158 ng/mL and the limit of quantification value was 0.

Cationic Micelle-like Nanoparticles as the Carrier of Methotrexate for Glioblastoma Treatment.

In the present study, ultra-small, magnetic, oleyl amine-coated FeO nanoparticles were synthesized and stabilized with a cationic ligand, cetyltrimethylammonium bromide, and an anticancer drug, methotrexate, was incorporated into a micelle-like nanoparticle structure for glioblastoma treatment. Nanoparticles were further characterized for their physicochemical properties using spectroscopic methods. Drug incorporation efficiency, drug loading, and drug release profile of the nanoparticles were investigated.

A Phosphatidyl Conjugated Telomerase-Dependent Telomere-Targeting Nucleoside Demonstrates Colorectal Cancer Direct Killing and Immune Signaling.

Telomerase and telomeres are crucial in cancer cell immortalization, making them key targets for anticancer therapies. Currently, 6-thio-dG (THIO) combined with the anti-PD-1 inhibitor Cemiplimab is under phase II clinical investigation (NCT05208944) in NSCLC patients resistant to prior immunotherapies. This study presents the design, synthesis, and evaluation of novel bimodular conjugate molecules combining telomere-targeting nucleoside analogs and phosphatidyl diglyceride groups.

Biological Characterization of One Oxadiazole Derivative (5(4-Hydroxyphenyl)-2-(N-Phenyl Amino)-1,3,4-Oxadiazole): In Vitro, In Silico, and Network Pharmacological Approaches.

Oxadiazole compounds are of great interest because they have a range of biological activities ranging from antioxidants to anticancer agents. Against this background, we wanted to demonstrate the antioxidant, enzyme inhibitory, and anticancer effects of 5(4-hydroxyphenyl)-2-(N-phenylamino)-1,3,4-oxadiazole (Hppo). Antioxidant abilities were measured through free radical scavenging and reducing power tests.

Eco-friendly synthesis of CuO/g-C₃N₄/Fe₃O₄ nanocomposites for efficient magnetic micro-solid phase extraction (M-μ-SPE) of trace cadmium from food and water samples.

In this study, a green synthesis method for synthesizing a novel nanocomposite (CuO/g-C₃N₄/Fe₃O₄) utilizing renewable dragon fruit peels as the primary raw material was developed. Hydrothermal and thermal decomposition techniques were used for nanocomposite synthesis. This nanocomposite was subsequently employed for the separation and preconcentration of Cd(II) from various environments, including food and water samples.

Directed Energy Deposition of Parts with Internal Channels Using Removable Graphite Supports.

Additive manufacturing (AM) techniques have the potential to produce complex parts, and many of these techniques require the use of support structures to prevent deformations and to minimize thermal effects during the printing process, particularly when building overhangs and internal cavities. However, removing the support structures through postprocessing incurs additional costs and time penalties. Unlike other AM techniques, support structures are not used in directed energy deposition (DED) technique due to its working principle.

Whole-genome sequencing and genomic analysis of four strains newly isolated from human feces.

Background: Numerous studies have demonstrated that is closely associated with human health. These bacteria colonize the mucus layer of the gastrointestinal tract and utilize mucin as their sole source of carbon and nitrogen. spp.

Myrrh Oleo-Gum Resin as a Functional Additive in Pectin and κ-Carrageenan Composite Films for Food Packaging.

Myrrh oleo-gum-resin (MOGR) is a natural substance that has a rich history of medicinal use due to its anti-inflammatory, antimicrobial, and antioxidant properties. The present study reports on the fabrication and assessment of pectin and K-carrageenan composite films infused with varying proportions (0.3%, 0.

Camel milk extracellular vesicles/exosomes: a fascinating frontier in isolation and therapeutic potential.

Camel milk has a unique composition that sets it apart from other types of animal milk, which has captured the interest of medical and scientific communities. Extracellular vesicles (EVs) mainly contain exosomes (Exos, 30-200 nm) and microvesicles (MVs, 200-1000 nm). Camel milk EVs, particularly Exos, which we named EVs/Exos, have arisen as a fascinating area of scientific inquiry, holding enormous potential for the future of biomedicine due to their anticancer, antibacterial, antidiabetic nephropathy, and immunostimulatory impacts.

Fc-FcγRI Complexes: Molecular Dynamics Simulations Shed Light on Ectodomain D3's Potential Role in IgG Binding.

FcγRI plays a crucial role in the effector function of IgG antibodies, interacting with the lower hinge region of IgG1 with nanomolar affinity. Binding occurs specifically in domain 2 (D2) of the FcγRI ectodomain, while domain 3 (D3) is a flexible linker. The D3 domain is positioned away from the IgG binding site on the FcγRI and does not directly contact the Fc region.

Simultaneous quantitative screening of 53 phytochemicals from L. roots: a comparative study of supercritical CO, subcritical ethanol, and ultrasound-assisted extraction for enhanced antioxidant, antibacterial activities, and molecular docking study.

In this study, L. extracts were obtained using various green extraction techniques, including supercritical CO, subcritical ethanol, and ultrasound-assisted extraction, each performed under optimized parameters. The phytochemical content of the extracts was analyzed using the LC-MS/MS technique, quantifying 53 phytochemicals.

Exploring the immunomodulatory effects of sertraline: Cytokine modulation and signaling pathway dynamics.

This study explores the nuanced immunomodulatory effects of sertraline, which is widely used in the treatment of major depression, obsessive-compulsive disorder, and anxiety in adults and children. Recent investigations have emphasized the intricate interplay between depression and the body's inflammatory response. This has sparked an exploration into the impact of sertraline on the immune system, an area that still awaits comprehensive exploration.

The effect of digital obesity and phubbing level on life satisfaction: latent profile analysis.

Background: In this study, the effects of individuals' digital obesity and phubbing behaviors on their life satisfaction were investigated by latent profile analysis (LPA) method. LPA is a statistical technique used to identify unobserved subgroups within a population based on individuals' responses to various observed variables.

Methods: The present study was conducted in a correlational cross-sectional descriptive design between November 2023- January 2024.

Flexible solid-state supercapacitors based on biowaste-derived activated carbon and nanomaterials for enhanced performance.

Supercapacitors are energy storage devices with long cycle life that can harvest and deliver high power. This makes them attractive for a broad range of applications including flexible and lightweight wearable consumer electronics. In this work, we fabricate flexible solid-state supercapacitors with improved capacitance and cycle life.

Life-History Traits of Nikolsky, 1905 from Northeastern Anatolia.

In this study, the life-history traits of are presented for the first time. A total of 27 samples (17 ♂♂ and 10 ♀♀) from Iğdır Province, Türkiye, were aged using skeletochronology. Student's -test was performed to compare mean differences in the variables between sexes.

Evaluating the impact of boxing on prefrontal cortex activation and cognitive performance: A pilot study using fNIRS technology and the Stroop test.

This research sets out to investigate the differences in hemoglobin concentration occurring in the prefrontal cortex (PFC) during the administration of the Stroop test in active amateur boxers and to compare the obtained data regarding chronic traumatic brain injury with those of healthy individuals. The research was conducted at the Atatürk University Neuropsychology Laboratory. Participants consisted of 6 male boxers, aged 19.

The evaluation of . extract by GC-MS coupled with in silico study as potent inhibitors of human pancreatic lipase.

L. leaves have a long history of traditional use in treating hemorrhoids, diarrhea, rheumatic discomfort, and stomachaches. The aerial part of this plant is extracted using hexane after hydroalcoholic maceration.

The role of ceRNAs in breast cancer microenvironmental regulation and therapeutic implications.

The tumor microenvironment, which is the tailored physiological milieu of heterogeneous cancer cell populations surrounded by stromal and immune cells as well as extracellular matrix components, is a leading modulator of critical cancer hallmarks and one of the most significant prognostic indicators in breast cancer. In the last few decades, with the discovery of the interactions of ncRNAs with diverse cellular molecules, considerable emphasis has been devoted to understanding their direct and indirect roles in specific functions in breast cancer. Collectively, all of these have revealed that the competitive action of protein-coding RNAs and ncRNAs such as circRNAs and lncRNAs, which have a shared affinity for miRNAs, play a vital role in the molecular regulation of breast cancer.

Assessment of Non-Vitamin K Antagonist Oral Anticoagulant Dosing Patterns in Turkish Patients with Non-Valvular Atrial Fibrillation: A Multicenter, Cross-Sectional Study with Insights from the ASPECT-NOAC Study.

Objective: We aimed to assess the real-world label adherence of non-vitamin K antagonist oral anticoagulant (NOAC) dosing patterns, including apixaban, edoxaban, and rivaroxaban, in Turkish patients with atrial fibrillation.

Methods: This was an observational, prospective, cross-sectional, multicenter study. Patients with atrial fibrillation (AF) who were prescribed NOACs within the last 4 months were recruited from 34 cardiology clinics in Türkiye.

Neuroprotective Roles of Lauric Acid and Resveratrol: Shared Benefits in Neuroinflammation and Anxiety, Distinct Effects on Memory Enhancement.

Neuroinflammation can be triggered by a high-fat/high-fructose diet (HFFD), and CD36 may be an underlying mechanism. Lauric acid (LA), the major fatty acid in coconut oil, and resveratrol, the plant-based polyphenolic compound, may exert anti-inflammatory effects. Therefore, this study investigated the possible effects of LA and resveratrol on diet-induced neuroinflammation and CD36.

Naturally Occurring Flavonol, Quercetagetin 5,6,7,3',4'-Pentamethyl Ether (Marionol), as a Nontoxic Plant-Based Fluorescent Probe for Rapid, Sensitive, and Selective Detection of Cu in Water.

Herein, we report a naturally occurring flavonol, quercetagetin 5,6,7,3',4'-pentamethyl ether (known as marionol), as a nontoxic fluorescent probe for rapid, sensitive, and selective detection of Cu in water. The interaction between marionol and Cu ions is studied by various state-of-the-art spectroscopic techniques such as H NMR, UV-vis, fluorescence, and high-resolution mass spectrometry (HRMS). Marionol shows strong fluorescence quenching in the presence of Cu, whereas other interfering cations such as Fe, Co, Al, Pb, Hg, Zn, Mg, Mn, Ca, Cu, Ag, Na, and K produce negligible changes in fluorescence.