Scanty integration of osteochondral allografts cryopreserved at low temperatures with dimethyl sulfoxide.

Purpose: To compare the integration of osteochondral allografts cryopreserved at different temperatures and different concentrations of dimethyl sulfoxide in an in vivo sheep animal model.

Methods: Thirty-six adult sheep were randomly allocated to 6 groups of allograft osteochondral transplantation. Six osteochondral cylinders were stored for 6 weeks at -80°C; 6 at -80°C with 10% dimethyl sulfoxide (DMSO); 6 at -80°C with 10% DMSO for 90 min; 6 at -186°C; 6 at -186°C with 10% DMSO; 6 at -186°C for 90 min.

The effects of previous meniscus and anterior cruciate ligament injuries in patients with total knee arthroplasty.

Background: Patients undergoing total knee replacements constitute a suitable population to study the natural history of traumatic joint injuries.

Material And Methods: We studied all the patients who received a TKA (Total knee arthroplasty) over the course of one year, in five different centers. The study included 474 patients who had undergone primary TKA for knee OA over a one-year period.

Platelet-rich plasma, rhOP-1 (rhBMP-7) and frozen rib allograft for the reconstruction of bony mandibular defects in sheep. A pilot experimental study.

A 6 cm bony defect in the mandible of 15 sheep, 8 years old, was reconstructed using variously allograft of frozen rib, rhOP-1 (rh BMP-7), platelet-rich plasma (PRP), and a combination of frozen rib allograft and rhOP-1. The histological, histomorphometric, immunohistochemical and radiographic features of reconstruction were analysed. The animals were euthanised at 2 months postoperatively.

Computed tomography-based study of age- and sex-related variation in morphology of the femur.

Background: The femur has a complex shape with marked individual differences. The aim of our study was to investigate the anatomy of the femur in normal subjects using computed tomography imaging with the aim of building a digital database of human femoral anatomy.

Material And Methods: We studied age- and sex-related variation in the shape of the femur in 169 normal subjects (80 men and 89 women) using Computed Tomography.