[Magnetic resonance tomography in the diagnosis of lung metastases in the mediastinum and thorax].

The results of MRI in 81 patients with morphologically verified lung cancer, mainly Stages IIIA and IIIB, were analyzed. They were compared with CT data in 37 cases and surgical findings in 28. MRI was performed by using Magnaview 0.

[Assessment of genotoxicity and late effects of radiation and chemical exposures].

The 3-month-old female rats received with drinking water PbCl2 or Hg2(NO3)2 in concentrations 100 or 1 mkg/l in account to metal, respectively, during 1 month before and 1 month after single gamma-irradiation with 25 or 50 cGy doses. The features of action of lead- and mercury-ions revealed in combination with low doses radiation. In case of the mercury ions introduction the relationships had been shown between early postradiation biochemical effects (changes of blood leucocyte DNA indexes) and blood granulocyte changes in 1 month after irradiation, and correlation of postradiation repair results with life span shortening as well.

[Magnetic resonance angiography in diagnosis of head and neck vessels diseases].

Aiming to study diagnostic potential of MRA 286 patients have bean observed with pathology of the brain vessels. High efficiency of MRA has been confirmed: sensitivity and specificity with vascular malformations were 98% and 96%, with arterial aneurysm it was 97% and 82%, with stenosis of more than 50% it was 98% and 46%, with stenosis of less than 50% it was 96% and 84%, with thrombosis--100% and 100%. It was noted that TOF method is the most informative nature to estimate the arterial bed.

Toward a heart rate and axillary temperature chronome in schizophrenia: gauge of disease severity.

The heart rate and axilliary temperature of 17 patients with schizophrenia were measured every 3 hours during waking for 4 days. In 28 profiles, large inter- and intra-individual variations notwithstanding, relations between the time structures (chronomes) of heart rate and axillary temperature are assessed and further examined from the viewpoint of their bearing on the severity of the patients's condition.

Enhanced circasemiseptan (about 3.5-day) variation in the heart rate of cancer patients?

In addition to prominent circadian and circannual components, an about half-weekly (circasemiseptan) pattern was shown earlier to characterize mitotic activity in cancer patients. A circasemiseptan variation in heart rate and circadian rhythms in heart rate and axillary temperature of cancer patients are assessed herein. These variables could be tested as putative marker rhythms for the optimization of radio- and/or chemotherapy by timing which, from a practical viewpoint, may be easier to implement along the scale of the week than that of the day.

Leukopenia prognosis during radiation therapy in patients with Hodgkin's disease.

The investigation goal of the present report is to use the early post-radiation peripheral blood DNA content changes during radiotherapy (RT) of cancer patients for the prognosis of the subsequent leukopenia value. Twenty-three primary patients with II-III stage Hodgkin's disease were treated at the linear accelerator of 15 Mev electrons by usual fractionation to total 40 Gy dose. The blood DNA content was fluorometrically determined by 4', 6-diamidino-2phenylindole before treatment, then 24 hrs after the 1st irradiation dose, in the middle and at the end of RT course.

Leukopenia prognosis by radiation therapy of patients with Hodgkin's disease.

The investigation goal of the present study is the possible utilization of early postradiation peripheral blood DNA content changes during radiotherapy (RT) of cancer patients for prognostic purposes related to the subsequent ascertaiment of leukopenia values. Twenty-three primary patients with II-III stage Hodgkin's disease were treated at the linear accelerator of 15 Mev electrons by usual fractionation to a total dose of 40 Gy. The blood DNA content was fluorometrically determined by 4',6-diamidino-2-phenylindole before treatment, 24 hrs after the first irradiated dose, in the middle and at the end of RT course.

X-irradiation chronosensitivity and circadian rhythmic proliferation in healthy and sarcoma-carrying rats' bone marrow.

Mitotic activity of bone marrow and tumor of sarcoma-bearing rats and of bone marrow of healthy controls is circadian periodic. Whereas the circadian rhythm in mitotic activity of bone marrow is similar for intact and tumor-bearing rats, with a peak occurring shortly after the onset of the dark (activity) span, the circadian rhythm in mitotic activity of tumor has a much smaller amplitude and a different acrophase occurring late in the dark span. This difference in acrophase of mitotic activity of bone marrow and tumor has important implications for scheduling the administration of oncotherapy.

Circasemiseptan (about-half-weekly) and/or circaseptan (about-weekly) pattern in human mitotic activity?

This review and metachronanalysis was prompted by the presence of a circasemiseptan pattern (P < 0.05) found by population-mean cosinor in published data characterizing murine malignant growth after treatment with cyclophosphamide (1-4). For cancer chronotherapy (5-9), the analyses serve to suggest the desirability to extend the focus beyond circadian aspects of drug timing and drug effect to a broader view that takes into account as much of the body's make-up in time as is practical.

Arterioportal fistulas (APF) in liver tumors: prognosis in relation to treatment.

Prognosis of 16 patients with hepatic tumors and angiographically proven arterioportal fistulas was analysed in relation to treatment. Six patients received only conservative therapy; they all died of variceal bleeding in the course of two months after angiography. Hepatic resection was performed in four patients; three of them are still alive 13-52 months later including two free of both the tumor and portal hypertension.

Determination of some nuclear deoxyribonucleases in X-irradiated rat thymocytes.

The spectrum of nuclear nucleases in control and irradiated (4 Gy) thymocytes has been investigated. Using the method of SDS electrophoresis of nuclear proteins in 3H-DNA-polyacrylamide gels a number of polypeptides of MW. 35, 32, 17.

Intrahepatic spontaneous arterioportal fistula: duplex ultrasound diagnosis and angiographic treatment.

A 54-yr-old male with portal hypertension received ineffective medical therapy for the diagnosis of portal hepatic cirrhosis. Duplex ultrasound (US) revealed pulsatile arterial flow in the right main portal vein. The correct diagnosis of intrahepatic arterioportal fistula was established and confirmed by angiography.

Transcatheter treatment of splenic artery aneurysms (SAA). Report of two cases.

Splenic artery embolization with steel coils was performed in two patients who both had large splenic artery aneurysms and hepatic cirrhosis complicated by hypersplenism. A good clinical effect was noticed after the procedure. It was concluded that this treatment is safe and effective and decreases the risk of splenic artery rupture.

Increased cancer risk as a genetic effect of ionizing radiation.

The well known genetic effects of ionizing radiation include severe developmental disorders in the progeny of irradiated parents resulting in embryonic death, stillbirth and early postnatal mortality, congenital abnormalities, malformations and fertility disturbances in live-born organisms. These effects are considered to be due to gross mutations (genomic, chromosomal and those of essential genes). Physiological inferiority and an increased cancer risk in phenotypically normal offspring of irradiated parents appear to be two further types of genetic effect of radiation.

Nuclear protein synthesis in thymocytes of X-irradiated rats.

The biosynthesis and phosphorylation of nuclear proteins of thymocytes were investigated in rats after 4.0 Gy whole-body X-irradiation during the period which precedes DNA degradation in lymphoid cells. Proteins were separated by two-dimensional gel-electrophoresis, detected by Coomassie blue staining.

Urethane-induced lung adenomas in the first-generation progeny of irradiated male mice.

A carcinogenic effect of urethane on the first-generation progeny of irradiated male mice was investigated. Seventy SHR male mice were exposed to a single total-body X-ray irradiation at a dose of 4.2 Gy.

Thymocyte membrane changes and modifications of interphase death.

A reduction in the rate of interphase death of X-irradiated thymocytes is observed when they are previously treated with triton X-100 or trypsin at low concentrations. The data obtained demonstrate the importance of the structural integrity of the cell surface in the initiation of processes leading to interphase death of lymphoid cells.