Endovascular interventions in advanced cancer of the uterus.

Purpose: The primary endpoint of this study was to estimate the efficacy of endovascular interventions -EVI- (occlusion and chemoinfusion of the internal iliac arteries- IIA) in the control of bleeding of patients with advanced cervical and endometrial cancer. Tumor response and survival were also estimated.

Patients And Methods: EVI were carried out in 95 patients with advanced uterine carcinoma (study group).

[Antineoplastic effect of glutapyrone in continual gamma-irradiation of rats].

In experiments on rats (290 animals) exposed to chronic gamma-radiation with the total dose of 10.0 Gy it was detected that prescription of synthetic pharmaceutical of the dihydropyridine class--glutapyrone--together with drinking water during 6 months reduced the rate of malignant neoplasms from 26.5% in the control group to 13% in the treated animals.

[The influence of geomagnetic field on blood leukocyte radiosensitivity and gender determination in humans].

The gender and age features of the geomagnetic field (GMF) influence (K-indexes) on the leukocyte radiosensitivity (S) in human blood in case of normal and enhanced levels of metal-ecotoxicants (Pb, Cd, Hg, Mn, Zn, Cu) in blood was studied, as well as the impact of the GMF intensity alterations on the child gender determination. In the whole studied population (n = 244) it was observed a negative relationship between S- and K-indexes. It was shown that the most changes of blood leukocyte radiosensitivity depended on the GMF oscillations in men older than 45 years.

[Complex radiation diagnosis of post-operative recurrent hepatic tumors].

The postoperative course of the disease was studied in 63 patients operated on for malignant hepatic lesion in 1990-1998. The pattern of surgical intervention-caused hepatic changes, which is observed at ultrasonography, CT, MRI, angiography, and oil-injected CT is described. Recurrences took place at the site of resection (9.

[Interventional radiological treatment of non-colorectal liver metastases].

Transcatheter treatment was performed in 81 patients with unresectable non-colorectal liver metastases. Effectiveness increased in the following order: hepatic artery infusion--arterial chemoembolization--combined, arterial and portal vein oily chemoembolization. The mean survival rates for these methods were 8.

[Application of new radiopharmaceutical "Sodium 11c-butyrate" and positron emission tomography in patients with coronary artery disease].

Unlabelled: The aim of this study was to examine the diagnostic value of Sodium 11C-Butyrate (11C-Butyrate) in assessing perfusion and oxydative metabolism in patients with coronary artery disease (CAD). 41 patients (39 male and 9 female, mean age 48 +/- 11) with CAD were investigated. PET-scans were performed twice: at 2-7 min and 25-31 min after i.

[Narrow photon-beam radiation therapy unit].

The Central Research Institute of Roentgenology and Radiology and the Research and Production Complex, Radiation Training Center, D. V. Efremov Research Institute of Experimental Physics have been the first in Russia to design a narrow photon-beam unit for stereotactic radiation therapy of intracranial small formation.

[Experience on clinical application of positron emission tomography with a new radiopharmaceutical preparation sodium 11C-butyrate in differential diagnosis of pathological volume in brain formation].

The study was aimed to investigate the possibilities of the application of a new radiopharmaceutical--"Sodium butyrate, [1-(11)C]" (11C-Butyrate) for differential diagnosis of pathological volume brain formations. Positron emission tomography (PET) ("Ecat Exact 47", Siemens) of the brain was performed in 24 patients (14 male & 10 female, aged 19-56). The scanning was carried out as static scan 4-5 min after intravenous administration of 250-350 Mbq 11C-Butyrate and proceeded within 15-20 min.

[Proton magnetic resonance spectroscopy in the diagnosis of brain diseases].

The role and position of proton magnetic resonance spectroscopy have been studied in diagnosis of brain diseases. 114 patients with various diseases of the brain have been examined (multiple sclerosis--41, insults of different etiology--17, encephalopathy--12, AIDS infection--23, epilepsy--12, reduction of the intellectual ability of various etiology--9). MR tomography and 1HMR Spectroscopy have been done with Magnetom "Vision", 1.

[Magnetic soft siloxane material for arterial embolization and hyperthermia of malignant tumors].

A newly developed polysiloxan material for arterial embolization of parenchymatous organs is described. This new agent can be used for distal-proximal embolization with following local hyperthermia. The preliminary results of clinical use are presented.

[Gene expression profiles of protein kinases and phosphatases obtained by hybridization with cDNA arrays: molecular portrait of human prostate carcinoma].

Hybridization with cDNA arrays was used to obtain expression profiles of 263 protein-tyrosine kinase (PTK), protein-tyrosine phosphatase (PTP), dual-specific phosphatase (DuSP), and other genes for the normal prostate tissue, primary prostate carcinomas (PC) of 84 patients, 7 xenografts, and 5 carcinoma cell lines. Analysis of 96 profiles revealed eight clusters of genes coexpressed in PC (coefficient of correlation r > 0.7).

[Genetic and somatic effects of ionizing radiation in humans and animals (comparative aspect)].

Genetic effects of ionizing radiation in the progeny of exposed parents could be conventionally subdivided on three main types. 1. Severe developmental disorders (fetus death, stillbirth, early postnatal mortality, malformation, hereditary disease, sterility).

[Molecular portrait of human kidney carcinomas: the gene expression profiling of protein-tyrosine kinases and tyrosine phosphatases which controlled regulatory signals in the cells].

Hybridization with cDNA arrays was used to obtain expression profiles of 214 protein-tyrosine kinase, protein-tyrosine phosphatase, dual-specific phosphatase, and other genes for kidney carcinomas (KC) and normal kidney tissues of 34 patients and for seven carcinoma cell lines. Computer analysis revealed three clusters of genes coexpressed in KC. A proliferating-cell gene cluster included MET, VIM, MYC, TOP2A, PCNA, etc.

[Comparison of cytogenetic response of human lymphocytes to in vivo and in vitro exposure to low-dose gamma rays. Translocations and dicentrics detected by the FISH technique].

On peripheral lymphocytes of 5 cancer patients undergone wholebody therapeutic irradiation (at daily dose of 10 cGy up to total dose 50 cGy of 60Co gamma-rays) the dose response of unstable and stable chromosomal exchanges detected by FISH was compared with the dose response of the some aberrations in lymphocytes irradiated in vitro. The dose response fitted well to linear function. For dicentrics the lower slope of dose-response curve was found for in vivo irradiated lymphocytes as compared to the dose-response curve obtained for in vitro irradiated lymphocytes of the same patients.

[SPECT and MRT in the diagnosis of myocarditis of mild and moderate severity].

Technetium-99mWBC SPECT and contrast material enhanced MRI were used for the diagnostics of mild myocarditis. The use of labeled leukocytes and paramagnetic contrast agent allow visualizing inflammation of myocardium and assessing the efficacy of treatment. 49 patients aged 14 to 49 years old were studied.

Analysis of chromosome aberrations by FISH and Giemsa assays in lymphocytes of cancer patients undergoing whole-body irradiation: comparison of in vivo and in vitro irradiation.

Purpose: To study the cytogenetic effects of fractionated radiotherapy in peripheral blood lymphocytes of five cancer patients. In vitro experiments were performed in parallel using the same dose range and a comparison was made of the induced frequencies of stable and unstable chromosome aberrations. The object was to clarify the use of an in vitro calibration curve for immediate and retrospective dosimetry in cases of radiation accidents.

An investigation of the age-dependency of chromosome abnormalities in human populations exposed to low-dose ionising radiation.

Among various cytogenetic changes stable chromosome aberrations (SCHA) seem to be the most significant for ageing and carcinogenesis. Being nonlethal they can persist through cell divisions and accumulate in time. We studied the age response of SCHA (translocations and insertions) in normal and radiation exposed human populations.

[Comparison of cytogenic response of human lymphocytes to in vivo and in vitro exposure to low doses of gamma-rays. Unstable chromosomal exchanges detected by FPG techniques].

On peripheral lymphocytes of eight cancer patients undergone whole-body therapeutic irradiation (at daily dose of 10 cGy up to total dose of 50 cGy of 60Co gamma-rays) the dose-response of unstable chromosome exchanges (dicentrics and centric rings) was studied. This dose response fitted well linear function. The lower slope of dose-response curve was found for in vivo irradiated lymphocytes as compared to the dose response curve obtained for in vitro irradiated lymphocytes of the same patients.

[Diagnostic possibilities of magnetic resonance cholangiopancreatography].

Studies for 39 patients have been done with the use of a new non-invasive method of observation--MR cholangiopancreatography,--that enables to get a high contrast-enhanced image of the intrahepatic, extrahepatic and pancreatic ducts without administration of the contrast agents and invasive interventions. High diagnostic efficiency of the method has been proved in patients with diseases of bile ducts and pancreas. The observation technique has been optimized and semiotics has been clarified in cases of various diseases that cause on obstruction of the biliferous tracts.

[Magnetic resonance tomography in the diagnosis of breast tumors].

A complete examination (mammography, ultrasonography and magnetic resonance tomography) has been made for 82 patients with breast masses. A high diagnostic efficacy of the dynamic contrast-enhanced MRT of the breast masses has been proved. The paper showed the advantages of dynamic contrast-enhanced tomography, as compared to mammography and US in cases with the small carcinomas developed on the background of the marked fibroadenomatous changes in the breast, in the dense or deformed glandular tissue, in cases of the postoperative scarring as well as with retromammary localization of the tumors.

[Diagnostic possibilities of contrast magnetic resonance tomography].

The practice of examinations of more than 400 patients in the diagnostic center of CRIRR showed a high diagnostic efficiency of contrast MRA, especially in stenoses, occlusions, pathologic bends of the brachiocephalic vessels; aneurysms and stenoses of the abdominal and thoracic aorta, stenoses and occlusions of visceral branches of the abdominal aorta, iliac arteries including condition of vessels after surgical correction. Valuable facts have been obtained in vasorenal hypertension caused by stenoses, occlusions, extravasal compressions, additional arteries, and in the portal system (thrombosis of the main trunk and branches of the portal vein, signs of portal hypertension).

[Effect of age and radiation exposure on the frequency of translocations and dicentrics detected by FISH method in human lymphocytes].

The frequencies of translocations and dicentrics detected by "chromosome painting" in lymphocytes were estimated in 115 healthy donors and in 273 people exposed to uncontrolled irradiation at low doses 1-4 years ago. Age responses of both types of exchanges at the age range from 3 to 85 years fit to quadratic model. The frequency of translocations grew faster with age than the frequency of dicentrics.

[Long-term results of endovascular treatment of metastatic renal cell cancer].

The authors analyse the long-term results of treatment of 106 patients with advanced renal cell carcinoma. The patients were divided in two groups. Group 1 (42 patients) included cases with single metastatic lesion.