1 results match your criteria: "Research Institute of Qinghua University in Shenzhen[Affiliation]"
[Study on absorption mechanism of puerarin and its nanoparticles across Caco-2 cell model].
Zhong Yao Cai
August 2009
Research Institute of Qinghua University in Shenzhen, Shenzhen 518057, China.
Article Synopsis
- The study aimed to investigate how puerarin and its nanoparticles are absorbed in a Caco-2 cell model, focusing on the effects of time and drug concentration.
- Using high-performance liquid chromatography, researchers found that puerarin-PLGA-NP significantly enhances the drug's absorption through mechanisms beyond simple passive diffusion, including better dispersion and interaction with the intestinal lining.
- The findings suggest that while the primary absorption method is passive transfer, the use of nanoparticles (Puerarin-NP) notably improves the drug's uptake in intestinal cells.