Correction: Mallphanov et al. Novel Approach to Increasing the Amplitude of the Mechanical Oscillations of Self-Oscillating Gels: Introduction of Catalysts Both as Pendant Groups and as Crosslinkers. 2024, , 727.

In the original publication [...

[Nosological aspects of the petrification and ossification processes in the lungs].

Microscopic changes in the lung biopsies of 16 adult patients of both sexes without clear clinical symptoms are described. According to X-ray examination data, disseminated process in the lungs was diagnosed in 4 patients, interstitial pneumonia in 4, osteoplastic pneumopathy in 3, as well as tuberculosis, bronchiolitis and a number of others. Microscopic examination showed that the patients had various forms of petrification and ossification of the lungs, diagnosed clinically and radiologically in only 3 cases.

Biochip-Based Identification of Mycobacterial Species in Russia.

Infections caused by nontuberculous mycobacteria (NTM) are rising globally throughout the world. The number of species isolated from clinical samples is steadily growing, which demands the implementation of a robust diagnostic method with wide specificity. This study was carried out in in 2022-2024 in three clinical antituberculosis centers in the biggest cities of Russia: Moscow, Saint Petersburg, and Novosibirsk.

Antimycobacterial Activity of Essential Oils from Bulgarian Species Against Phylogenomically Different Strains.

In this study, we aimed to assess the activity of the essential oils from four Bulgarian oil-bearing roses Mill., L., L.

Connexins and Aging-Associated Respiratory Disorders: The Role in Intercellular Communications.

This article reviews the contemporary understanding of the functional role of connexins in intercellular communications, their involvement in maintaining cellular and tissue homeostasis, and in aging-associated respiratory disease pathogenesis. Connexins are discussed as potential therapeutic targets. The review particularly focuses on the involvement of gap junction connexins and hemichannels in the transfer of calcium ions, metabolite molecules, ATP, and mitochondria through the cell membrane.

Mimicking Marker Spread After Disruption of the Blood-Brain Barrier with a Collagen-Based Hydrogel Phantom.

Recent studies of the spread of substances penetrating the disrupted blood-brain barrier have revealed that the spread in the parenchyma surrounding a vessel has a complex character. In particular, a flow-like motion occurred for a short time that exhibits a smooth transition to diffusional spread. To address the possible physical background of such behavior, we created a system formed by a hydrogel medium with a channel filled by a marker solution, which can serve as a physical model mimicking the process of a substance passively spreading to the brain's parenchyma when the blood-brain barrier is disrupted.

Novel Approach to Increasing the Amplitude of the Mechanical Oscillations of Self-Oscillating Gels: Introduction of Catalysts Both as Pendant Groups and as Crosslinkers.

For the first time, we introduced chemomechanical self-oscillating poly(N-isopropylacrylamide)-based gels containing catalytically active Fe or Ru complexes both as crosslinkers and as pendant groups. All the obtained gels exhibited sustained autonomous oscillations driven by the Belousov-Zhabotinsky reaction within their structure. The Ru complex-based gels also demonstrated pronounced chemomechanical oscillations; they periodically swelled/shrunk when the catalyst was reduced/oxidized.

[Inflammaging: the signaling role of p65 protein from the NF-κB family.].

Inflamaging is a chronic, low-grade inflammation that occurs due to a disruption in the regulation of the immune system during the aging process. This condition is associated with an increased risk of age-related illnesses, such as cardiovascular disease, neurodegenerative conditions, and metabolic disorders. Transcription factor NF-κB is one of the primary regulators of innate and adaptive immune responses, and its activation leads to the production of pro-inflammatory cytokines and chemokines that contribute to inflamaging.

Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes.

Neurons become more vulnerable to stress factors with age, which leads to increased oxidative DNA damage, decreased activity of mitochondria and lysosomes, increased levels of p16, decreased LaminB1 proteins, and the depletion of the dendritic tree. These changes are exacerbated in vulnerable neuronal populations during the development of neurodegenerative diseases. Glu-Asp-Arg (EDR) and Lys-Glu-Asp (KED), and Ala-Glu-Asp-Gly (AEDG) peptides have previously demonstrated neuroprotective effects in various models of Alzheimer's disease.

3-Diazopiperidine-2,4-diones as Convenient Precursors to Rare Polysubstituted Spiro Bis-β,γ-lactams and 2-Oxopyrrolidine-3-carboxylic Acid Derivatives via the Thermally Promoted Wolff Rearrangement.

Herein, we describe a diastereoselective and straightforward synthetic approach to polysubstituted spirocyclic bis-lactams bearing both β- and γ-lactam cores with diverse substitution patterns. The method developed is based on a microwave-assisted Wolff rearrangement/Staudinger [2 + 2] cycloaddition sequence involving 3-diazopiperidine-2,4-diones and imines. The corresponding reaction tolerates a wide range of functionalities in both substrates, giving the target bis-lactams in generally high yields.

[Clinical, endoscopic, laboratory and immunomorphological parameters in predicting the occurrence of colorectal cancer in patients with diverticular disease of the colon].

Aim: To define the role of clinical, endoscopic, laboratory and immunomorphological parameters in predicting the occurrence and course of colorectal cancer (CRC) in patients with diverticular disease of the colon (DDC).

Materials And Methods: One hundred and seventy five people with DDC were examined, divided into 3 groups: group 1 - 85 patients with DDC; group 2 - 45 with DDC in combination with adenomatous polyps (AP); 3rd group - 45 with DDC with established CRC (I or II stage). The control group consisted of 30 practically healthy people.

5-Diazo Dihydrouracils: Preparation and Some Transformations.

An approach to a new type of diazo reagents─diazo dihydrouracils─has been developed, and various transformations of the obtained diazo heterocycles have been studied, demonstrating their high synthetic potential for obtaining structurally diverse derivatives based on the privileged dihydrouracil scaffold. The X-H insertion reactions provide high yields of a variety of 5-substituted dihydrouracils. Cyclopropanation and 1,3-dipolar cycloaddition reactions involving a carbonyl ylide intermediate have been carried out to give spiro-annulated derivatives.

Dominant Frequency of Ventricular Fibrillation During Ischemia and Reperfusion.

Ventricular fibrillation (VF) in dogs is characterized by a rapid increase in its dominant frequency during the 1st minute of reperfusion followed by its decrease during the 2nd minute of reperfusion. The longer is ischemia in VF, the greater is the increase in dominant VF frequency during reperfusion. The 1st minute of reperfusion is characterized by a 1.

Melatonin Receptors and Serotonin: Age-Related Changes in the Ovaries.

Introduction: Melatonin and serotonin can influence certain aging processes in the ovaries. The main melatonin receptors are represented by types MT1 and MT2. The goal of investigation.

Inflammaging: Expansion of Molecular Phenotype and Role in Age-Associated Female Infertility.

Cellular aging is considered as one of the main factors implicated in female infertility. We evaluated the expression of senescence-associated secretory phenotype (SASP) markers and additional molecular factors in an in vitro model of cellular aging. We induced genotoxic stress (UVB/UVA ray irradiation) in primary human endometrial cells obtained from female subjects of young reproductive age (<35 years of age).

Co-Complexes-Based Self-Oscillating Gels Driven by the Belousov-Zhabotinsky Reaction.

We report the synthesis of novel cobalt complexes-based catalysts designed for the oscillatory Belousov-Zhabotinsky (BZ) reaction. For the first time, we introduce cobalt complex-based self-oscillating gels that demonstrate autonomous color oscillations within a BZ reagent solution, functioning without the need for any external stimuli. We created acrylamide-based self-oscillating gels containing immobilized tris(2,2'-bipyridine)cobalt(II) or tris(1,10-phenanthroline)cobalt(II) complexes and gels containing covalently bound (5-acrylamido-1,10-phenanthroline)bis(2,2'-bipyridine)cobalt(II), (5-acrylamido-1,10-phenanthroline)bis(1,10-phenanthroline) cobalt(II), or tris(5-acrylamido-1,10-phenanthroline)cobalt(II) complexes.

Azide-based preparation of fused heterocyclic imines and their multicomponent reactions.

Structurally diverse pyrroles, indoles and imidazoles bearing an -ω-azidoalkyl moiety and an aldehyde or ketone function were prepared and successfully introduced into imine generation the intramolecular Staudinger/aza-Wittig tandem reaction. Reduction of the generated imines led to medicinally relevant nitrogen-containing fused heterocycles such as tetrahydropyrrolo[1,2-]pyrazines and diazepines. Rare 8-membered hexahydropyrrolo[1,2-][1,4]diazocine and 9-membered dihydro-4,8-(metheno)pyrrolo[1,2-][1,4]diazacycloundecine were also synthesized.

Access to 2-oxoazetidine-3-carboxylic acid derivatives via thermal microwave-assisted Wolff rearrangement of 3-diazotetramic acids in the presence of nucleophiles.

In this work, we report an efficient approach to 2-oxoazetidine-3-carboxylic acid derivatives based on a thermally promoted Wolff rearrangement of diazotetramic acids in the presence of nucleophiles. The method allows easy variation of the substituent in the exocyclic acyl group by introducing different -, -, and -nucleophilic reagents into the reaction. The reaction of chiral diazotetramic acids leads exclusively to -diastereomeric β-lactams.

[Molecular markers of M. tuberculosis virulence in lung tissue (experimental study)].

Unlabelled: More than a quarter of the world's population is infected with . However, only about 10% of those infected develop active TB. This indicates a key role for innate immunity in limiting M.

TB/FLU-06E Influenza Vector-Based Vaccine in the Complex Therapy of Drug-Susceptible and Drug-Resistant Experimental Tuberculosis.

The steady rise of drug-resistant tuberculosis (TB), which renders standard therapy regimens ineffective, necessitates the development of innovative treatment approaches. Immunotherapeutic vaccines have the potential to effectively regulate the anti-TB immune response and enhance the efficacy of anti-TB treatment. In the present study, we aimed to evaluate the potency of the mucosal vector vaccine TB/FLU-06E as part of a complex treatment regimen for drug-susceptible (DS) or drug-resistant (DR) tuberculosis in C57BL/6 mice.

Molecular Periphery Design Allows Control of the New Nitrofurans Antimicrobial Selectivity.

A series of 13 new 3-substituted 5-(5-nitro-2-furyl)-1,2,4-oxadiazoles was synthesized from different aminonitriles. All compounds were screened in the disc diffusion test at a 100 μg/mL concentration to determine the bacterial growth inhibition zone presence and diameter, and then the minimum inhibitory concentrations (MICs) were determined for the most active compounds by serial dilution. The compounds showed antibacterial activity against ESKAPE bacteria, predominantly suppressing the growth of 5 species out of the panel.