Novel Nano-sized N-Thiazolylpyridylamines Targeting CDK2: Design, Divergent Synthesis, Conformational Studies, and Multifaceted In Silico Analysis.

This study involves the design, divergent synthesis, conformational and structural analysis, target prediction, and molecular docking simulations of novel nano N-thiazolylpyridylamines 2-7 and 10 as potential cyclin-dependent kinase 2 (CDK2) inhibitors. Using a divergent synthesis approach, the compounds were designed with structural variation and optimization in mind. The conformational and structural properties were explored through various spectroscopic techniques, confirming the structure, stability, and preferred conformations.

Comprehensive geological analysis and evaluation of the feasibility of renovating the Wanshunchang gas reservoir into a gas storage facility.

As many oil and gas reservoirs approach depletion stages in the future, alongside growing energy storage demands, constructing gas storage facilities becomes critical for ensuring a stable natural gas supply. Consequently, a comprehensive geological analysis is essential to evaluate the feasibility of converting depleted gas reservoirs into gas storage facilities. The W gas reservoir in the Sichuan Basin, China, is nearing depletion and presents potential for conversion into a gas storage facility.

Critical depth prediction based on in-situ stress and gas content model of deep coalbed methane in Liupanshui Coalfield in China.

In-situ stress plays a pivotal role in influencing the desorption, adsorption, and transportation of coalbed methane. The reservoir gas content represents a pivotal physical parameter, encapsulating both the coalbed methane enrichment capacity and the underlying enrichment law of the reservoir. This investigation collates, computes, and consolidates data concerning pore pressure, breakdown pressure, closure pressure, triaxial principal stress, gas content, lateral pressure coefficient, and other pertinent variables from coal reservoirs within several coal-bearing synclines in the Liupanshui coalfield, China.

Reducing transition costs towards carbon neutrality of China's coal power plants.

The same cumulative carbon emission reduction target can correspond to multiple emission reduction pathways. This study explores how different coal power transition pathways with the same cumulative emissions reductions impact the transition costs, by assessing the dynamic transition processes for coal plants adopting multiple mitigation technologies concurrently or sequentially, such as flexibility operation, biomass and coal co-firing, carbon capture and storage, and compulsory retirement. We develop a plant-level dynamic optimization model and apply it to China's 4200+ coal plants.

Research on the risk spillover effect between China's national carbon emissions trading market and crude oil futures market.

The development of China's National Carbon Market has strengthened the inherent link between the carbon market and the broader energy market, providing a potential for cross-market risk transmission resonance. Studying the risk spillover effects between China's National Carbon Market and the crude oil futures market is of significant practical importance, both in terms of carbon market development and carbon risk management. Based on the Maximal Overlap Discrete Wavelet Transform (MODWT), the price series are decomposed across multiple scales, and the risk spillover effects between the carbon market and the crude oil futures market are examined from both the time domain and the frequency domain.

Albizia procera-Derived Nitrogen-Doped Carbon for Advanced Energy Conversion, Storage, and Environmental Technologies.

This review explores the diverse applications of nitrogen-doped carbon derived from Albizia procera, known as white siris. Native to the Indian subcontinent and tropical Asia, this species thrives in varied conditions, contributing to sustainable development. The nitrogen-rich leaves of Albizia procera are an excellent source for synthesizing nitrogen-doped carbon, which possesses remarkable properties for advanced technologies.

Persistent but weak magnetic field at the Moon's midstage revealed by Chang'e-5 basalt.

The evolution of the lunar magnetic field can reveal the Moon's interior structure, thermal history, and surface environment. The mid-to-late-stage evolution of the lunar magnetic field is poorly constrained, and thus, the existence of a long-lived lunar dynamo remains controversial. The Chang'e-5 mission returned the heretofore youngest mare basalts from Oceanus Procellarum uniquely positioned at midlatitude.

Phase Diagram, Glassy Dynamics and Crystallization Kinetics of the Biobased Polyester Poly(ethylene 2,5-furanoate) (PEF).

We report the pressure-temperature (-) phase diagram, the origin of the subglass dynamics, and the crystallization kinetics of the biobased polyester poly(ethylene 2,5-furanoate) (PEF), through dielectric spectroscopy (DS) measurements performed as a function of temperature and pressure. The phase diagram comprises four different "phases"; glass, quenched melt, crystalline, and normal melt. The cold crystallization temperature, , increases linearly with pressure (according to the Clausius-Clapeyron equation) as / ∼ 240 K·GPa and is accompanied by a small change in specific volume (Δ = 0.

Predicting Source Rock Distribution of the Ninth Member of the Upper Triassic Yanchang Formation Based on Well-Logging Parameters and TOC Values in the Longdong Area, Ordos Basin, China.

In recent years, new oil reservoirs have been discovered and exploited in the ninth member (Chang 9 Member, Ty) of the Upper Triassic Yanchang Formation (Ty) in the Longdong area, Ordos Basin. Some studies have shown that the crude oils of the Chang 9 Member may originate from the Chang 9 source rock in some areas, which may be related to the distribution of the source rock. However, the distribution of the Chang 9 source rock in the Longdong area is still unclear, which hinders further exploration and development of petroleum.

Microbial Electrochemical Technologies: Sustainable Solutions for Addressing Environmental Challenges.

Addressing global challenges of waste management demands innovative approaches to turn biowaste into valuable resources. This chapter explores the potential of microbial electrochemical technologies (METs) as an alternative opportunity for biowaste valorisation and resource recovery due to their potential to address limitations associated with traditional methods. METs leverage microbial-driven oxidation and reduction reactions, enabling the conversion of different feedstocks into energy or value-added products.

Pulmonary exposure to renewable diesel exhaust particles alters protein expression and toxicity profiles in bronchoalveolar lavage fluid and plasma of mice.

Exposure to diesel exhaust is associated with increased risk of cardiovascular and lung disease. Substituting petroleum diesel with renewable diesel can alter emission properties but the potential health effects remain unclear. This study aimed to explore toxicity and underlying mechanisms of diesel exhaust from renewable fuels.

Impact of plasma discharge pressure on implant surface properties and osteoblast activities in vacuum-assisted plasma treatment.

Nonthermal plasma has been extensively utilized in various biomedical fields, including surface engineering of medical implants to enhance their biocompatibility and osseointegration. To ensure robustness and cost effectiveness for commercial viability, stable and effective plasma is required, which can be achieved by reducing gas pressure in a controlled volume. Here, we explored the impact of reduced gas pressure on plasma properties, surface characteristics of plasma-treated implants, and subsequent biological outcomes.

Exploration of flame characteristics of gasoline engine fuelled by gasoline-pentanol blends using combustion endoscopy.

Alcohol-based fuels have shown high compatibility with spark-ignition (SI) engines, which require improvements in fuel efficiency and emissions reduction to meet modern environmental standards. While extensive research has been conducted on ethanol and other lower-order alcohols, there has been comparatively limited investigation into higher-order alcohols like butanol and pentanol as fuel alternatives. Previous studies on pentanol-gasoline blends in SI engines have demonstrated improved engine performance and reduced emissions.

Characterization of the key aroma compounds in cigar filler tobacco leaves from different production regions.

Cigar tobacco leaves exhibited distinct regional characteristics, and aroma compounds were the key substances determining the different style features of cigars. However, the differences in aroma characteristics and the mechanisms of key aroma compound synthesis have not been fully elucidated. This study collected filler tobacco leaves (FTLs) from 5 representative domestic and international production regions.

Effectiveness of gaseous ozone on and bacterial loads on retailed meat sold at Iraqi Wasit markets.

Background: Ozone (O) is a promising alternative antibacterial agent that has recently been used in meat processing. The understanding of the appropriate functional settings of O for addressing food safety problems is still insufficient.

Aim: The aim of this study was, therefore, to investigate the effects of exposure to O on the bacteriological quality of retail meat inoculated with at refrigeration temperatures.

Sediment provenance of Late Carboniferous-Early Triassic in the Puyang area, Eastern North China Craton.

To reveal the stratigraphic age of the Shiqianfeng Formation in the eastern continental basin of the North China Craton and the provenance of its sediments from the Late Carboniferous to the Early Triassic, six sandstone samples from the Puyang area were selected for zircon U-Pb dating. The result show that the Shiqianfeng Formation in the eastern North China Craton belongs to the Early Triassic. According to the age clusters of six samples, considering the regional geological setting and the distribution of zircon ages in the potential provenance area, it can be inferred that the Inner Mongolia Paleo-uplift provided continuous provenance supply for the study area during the Late Carboniferous-Early Triassic.

Exploring endophytic fungi from Cynodon dactylon: GC-MS profiling and biological activity.

The rapid decline of significant plant species due to deforestation and slow regrowth has endangered many trees that are crucial for producing life-saving medications. This dual crisis of conserving plant biodiversity while meeting pharmaceutical demands necessitates innovative solutions. Endophytic fungi, naturally occurring symbionts within plants, present an eco-friendly and economically viable alternative.

Functional microorganisms in hydrogen production: Mechanisms and applications.

The rapid growth of global energy demand accelerates the development of sustainable, clean, and renewable energy sources. Biohydrogen production, driven by functional microorganisms, offers a promising solution. Multiple species of bacteria, fungi, microalgae, and archaea were able to produce hydrogen.

Integrated analysis of physiological and metabolic data uncovers essential dynamic mechanisms involved in the maturation of cigar tobacco leaves.

The quality of cigar tobacco leaves is profoundly affected by the timing of their harvest, with both early and late collections resulting in inferior characteristics. While the relationship between maturity and physiological metabolic processes is acknowledged, a comprehensive understanding of the physiological behavior of cigar leaves harvested at different stages remains elusive. This research investigated the physiological and metabolomic profiles of the cigar tobacco variety CX-014, grown in Danjiangkou City, Hubei Province, with leaves sampled at 35 (T1), 42 (T2), 49 (T3), and 56 (T4) days post-inflorescence removal.

A deep learning identification method of tight sandstone lithofacies integrating multilayer perceptron and multivariate time series.

Lithofacies classification and identification are of great significance in the exploration and evaluation of tight sandstone reservoirs. Existing methods of lithofacies identification in tight sandstone reservoirs face issues such as lengthy manual classification, strong subjectivity of identification, and insufficient sample datasets, which make it challenging to analyze the lithofacies characteristics of these reservoirs during oil and gas exploration. In this paper, the Fuyu oil formation in the Songliao Basin is selected as the target area, and an intelligent method for recognizing the lithophysics reservoirs in tight sandstone based on hybrid multilayer perceptron (MLP) and multivariate time series (MTS-Mixers) is proposed.

Network structures and mitigation potential of trade linked global agricultural greenhouse gas emissions.

Since agriculture is a major source of greenhouse gas emissions, accurately calculating these emissions is essential for simultaneously addressing climate change and food security challenges. This paper explores the critical role of trade in transferring agricultural greenhouse gas (AGHG) emissions throughout global agricultural supply chains. We develop a detailed AGHG emission inventory with comprehensive coverage across a wide range of countries and emission sources at first.

Seed-specific expression of AtWRI1 enhanced the yield of cotton seed oil.

The WRINKLED1 (WRI1) transcription factor controls carbon flow in plants through regulating the expression of glycolysis and fatty acid biosynthesis genes. The role of Gossypium hirsutum WRINKLED1 (GhWRI1) in seed-oil accumulation still needs to be explored. Multiple sequence alignment of WRI1 proteins confirmed the presence of two conserved AP2 domains.

The role of biosilica and its potential for sensing technologies: A review.

Efficiently managing agricultural waste while innovating to derive value-added products is a significant challenge in the 21st century. In recent decades, these by-products have been increasingly explored as alternative sources for materials such as biosilica. Biosilica is renowned for its high surface area, biocompatibility, chemical stability, and modifiable surface, which makes it suitable for various applications.

Heterogeneity and permeability estimation of pore-throat structure at different scales in deep tight sandstone reservoirs: A case study of Paleogene Hetaoyuan Formation in Anpeng area, Nanxiang Basin, China.

Clarifying the pore-throat size and pore size distribution of tight sandstone reservoirs, quantitatively characterizing the heterogeneity of pore-throat structures, is crucial for evaluating reservoir effectiveness and predicting productivity. Through a series of rock physics experiments including gas measurement of porosity and permeability, casting thin sections, scanning electron microscopy, and high-pressure mercury injection, the quality of reservoir properties and microscopic pore-throat structure characteristics were systematically studied. Combined with fractal geometry theory, the effects of different pore throat types, geometric shapes and scale sizes on the fractal characteristics and heterogeneity of sandstone pore throat structure are clarified.

Exploring sp. M21F004 for Biocontrol of Bacterial and Fungal Phytopathogens.

This study explores the biocontrol potential of sp. M21F004, a lactic acid bacteria (LAB) isolated from marine environments, against several bacterial and fungal phytopathogens. Out of 50 marine bacterial isolates, sp.