[The nephrogenic anemia: progression in comprehension of pathophysiology and a potential of the new approaches to safe therapy.].

The normocytic normochromic anemia is one of signs of progressing chronic kidney diseases mainly related to absolute or relative decreasing of production of erythropoietin and iron deficiency. The last decade discovery of hepcidin (regulator of iron homeostasis) and also various factors and signaling pathways regulating its metabolism the pathophysiology of anemia under chronic kidney diseases is understood significantly better. As a result, dramatically increased research concerning development of potentially new pharmaceuticals that can be used for treatment of kidney anemia with more or less efficiency and safety.

[Association Between T455C Polymorphism of Apolipoprotein C-III Gene, Insulin Resistance and Metabolic Syndrome Components].

Aim: to study an association between T455C apolipoprotein C-III (apo C-III) gene polymorphism, insulin resistance (IR), metabolic syndrome (MS) and its components in a Kyrgyz ethnic group.

Material And Methods: 259 persons: 162 patients with MS and 97 sex and age matched controls without MS, diabetes mellitus and cardiovascular diseases were included in the study. Clinical examination with arterial blood pressure, anthropometric data measurement and laboratory tests for blood glucose and lipid parameters were performed in all included persons.