Mutations of the VCORC1 Gene of Resistance to Anticoagulants in Synanthropic Rodents in Urbanized Areas of Russia.

This is the first study to analyze the variability of two exons (the 1st and 3rd) of the VCORC1 gene in Russian populations of mice and rats, namely, 125 Mus musculus and 19 Rattus norvegicus captured in 13 settlements. Previously, it has been shown that a number of mutations in these exons in the countries of Western Europe are associated with resistance to anticoagulants in synanthropic rodents. We did not find such mutations in house mice in Russia.

[Prospects and problems of current disinfectology].

Topical problems of modern disinfectology are formulated in connection with differences in the resistance of different microbial groups, species, strains to disinfectants, as well as with the "critical ability" of instruments and, accordingly, with different requirements to the necessary levels of decontamination. Factors determining the effectivity of disinfection are described. Requirements to "ideal" disinfectants and disinfectological technologies are considered.

[The subcellular mechanisms of the action of disinfectants. The effect of iodine and chloramine-B on bacterial ribosomes].

The composition of ribosomal material in bacterial cells of 5 families, subjected to the minimal bactericidal action of iodine and chloramine-B, was studied with the use of electrophoresis in polyacrylamide gel. The study demonstrated that under these conditions protein-synthesizing organelles of vibrios and bifidobacteria did not undergo perceptible changes, while Escherichia, Pseudomonas and bacilli essential ribosomal degradation was found to occur, which was manifested by a decrease in the intensity of bands 23S and 16S of ribosomal RNA. The conclusion was made that the in vivo destruction of ribosomes was not the direct result of the action of disinfectants, but mediated by some cellular mechanisms.