[Molecular mechanisms of tissue hypoxia and organism adaptation].

The mechanism for participation of aerobic energy metabolism in formation of urgent and long-term adaptation to hypoxia is under consideration. It is stated that changes in kinetic properties of mitochondrial enzyme complexes (MEC), primarily enzymes of the respiratory chain substrate region (MEC I), in response to oxygen shortage underlie diverse stages of bioenergetic (tissue) hypoxia. It was shown that economization of energy metabolism in adaptation to hypoxia occurs due to formation of a new mitochondrial population.