169 results match your criteria: "Research Clinical Center[Affiliation]"
Zh Nevrol Psikhiatr Im S S Korsakova
December 2024
GUTA-CLINIC LLC, Moscow, Russia.
J Gerontol A Biol Sci Med Sci
December 2024
Human Nutrition & Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK.
Biomarkers of ageing serve as important outcome measures in longevity-promoting interventions. However, there is limited consensus on which specific biomarkers are most appropriate for human intervention studies. This work aimed to address this need by establishing an expert consensus on biomarkers of ageing for use in intervention studies via the Delphi method.
View Article and Find Full Text PDFFront Psychol
November 2024
Developmental psychology & Family pedagogic department, Herzen University, Saint Petersburg, Russia.
Introduction: Adverse childhood experiences (ACEs) are a general term for a large group of nonequivalent situations that have the potential to traumatise a child. This risk factor is caused by a sensitive period of brain development, which is based on myelination, creation of synaptic connections and pruning. Dramatic environmental events during this period, such as history of institutionalisation, can disrupt optimal developmental pathways, leaving biological scars for life.
View Article and Find Full Text PDFSoft Matter
July 2024
Institute for Regenerative Medicine, Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow, 119991, Russia.
The mechanical properties of soft gels hold significant relevance in biomedicine and biomaterial design, including the development of tissue engineering constructs and bioequivalents. It is important to adequately characterize the gel's mechanical properties since they play a role both in the overall structural properties of the construct and the physiological responses of cells. The question remains which approach for the mechanical characterization is most suitable for specific biomaterials.
View Article and Find Full Text PDFObjective: To evaluate the feasibility of transthoracic CT-guided core biopsy of high pulmonary neoplasms using coaxial transport system in a day hospital; to analyze the effectiveness, nature and incidence of complications, as well as pain indicators in both groups.
Material And Methods: Transthoracic CT-guided core biopsy of high pulmonary neoplasms using coaxial transport system in a day hospital was performed in 184 patients for histological verification between March 2017 and December 2022.
Results: This method of transthoracic biopsies significantly (<0.
Nat Prod Res
March 2024
The White Sea Biological Station, Zoological Institute of Russian Academy of Sciences, Saint Petersburg, Russia.
The extract of the White Sea sponge (Pallas, 1766) exhibits cytotoxic and cytostatic effects. The main part of the extract consists of hydrophilic low molecular weight compounds: free amino acids (13.9%), glucose (19.
View Article and Find Full Text PDFZh Nevrol Psikhiatr Im S S Korsakova
December 2023
LLC «ORTO-BALANS», Krasnoyarsk, Russia.
PLoS One
February 2024
Department of Pediatrics, University of California, San Francisco, San Francisco, CA, United States of America.
Importance: Pregnancy induces unique physiologic changes to the immune response and hormonal changes leading to plausible differences in the risk of developing post-acute sequelae of SARS-CoV-2 (PASC), or Long COVID. Exposure to SARS-CoV-2 during pregnancy may also have long-term ramifications for exposed offspring, and it is critical to evaluate the health outcomes of exposed children. The National Institutes of Health (NIH) Researching COVID to Enhance Recovery (RECOVER) Multi-site Observational Study of PASC aims to evaluate the long-term sequelae of SARS-CoV-2 infection in various populations.
View Article and Find Full Text PDFZh Vopr Neirokhir Im N N Burdenko
December 2023
Federal Research Clinical Center of Intensive Care and Rehabilitology, Moscow, Russia.
Background: Management of patients in acute period of aneurysmal subarachnoid hemorrhage HuntHess grade IV-V is still a complex and unsolved problem, especially regarding surgical treatment and various complications.
Objective: To analyze postoperative outcomes in patients undergoing surgery in acute period of aneurysmal subarachnoid hemorrhage HuntHess grade IV-V between 2006 and 2020, as well as to assess various factors influencing treatment outcomes.
Material And Methods: We analyzed 163 patients who underwent surgery within 21 days after aneurysmal subarachnoid hemorrhage HuntHess grade IV-V.
Bull Exp Biol Med
October 2023
I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
The effect of the toxic dose of the muscle relaxant baclofen on the parameters of the cardiovascular and respiratory systems was studied in adult male Wistar rats (n=20). Systolic and diastolic BP, HR, and respiratory rate were measured; histological changes in the lungs 3, 4.5, and 24 h after drug administration.
View Article and Find Full Text PDFZh Nevrol Psikhiatr Im S S Korsakova
October 2023
JCL «Your Health», Kazan, Russia.
Diagnosis and treatment of early forms of cognitive impairment: possibilities of influencing neuronal energy metabolism. Resolution of the Council of Experts.
View Article and Find Full Text PDFBiochemistry (Mosc)
June 2023
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia.
Cancer virotherapy is an alternative therapeutic approach based on the viruses that selectively infect and kill tumor cells. Vaccinia virus (VV) is a member of the Poxviridae, a family of enveloped viruses with a large linear double-stranded DNA genome. The proven safety of the VV strains as well as considerable transgene capacity of the viral genome, make VV an excellent platform for creating recombinant oncolytic viruses for cancer therapy.
View Article and Find Full Text PDFBull Exp Biol Med
June 2023
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
The effect of humic acids and substances with similar action - derivatives of succinic acid (ethylmethylhydroxypyridine succinate) and combined agent consisting of succinic acid, nicotinamide, riboflavin, and riboxin on the performance and stress resistance of experimental rats was studied. Performance was assessed in the test of exhaustive forced swimming with a load, stress resistance was evaluated by the serum level of corticosterone and open field behavior, and the state of anaerobic metabolism was estimated by the serum level of lactate after swimming test. Humic acids from peat showed anti-stress activity comparable to that of the officinal preparation and preventive effect on fatigue during physical exercise.
View Article and Find Full Text PDFKhirurgiia (Mosk)
June 2023
Moscow Research Clinical Center for Tuberculosis Control, Moscow, Russia.
Objective: To evaluate the effectiveness of surgical treatment of patients with malignancies of lungs, pleura and chest wall in early and long-term follow-up period in anti-tuberculosis hospital.
Material And Methods: There were 2139 patients between 2016 and 2020. Chest tumors were diagnosed in 290 (13.
Biology (Basel)
May 2023
Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
Hepatitis C virus (HCV) is one of the basic culprits behind chronic liver disease, which may result in cirrhosis and hepatocarcinoma. In spite of the extensive research conducted, a vaccine against HCV has not been yet created. We have obtained human mesenchymal stem cells (hMSCs) and used them for expressing the HCV NS5A protein as a model vaccination platform.
View Article and Find Full Text PDFNutrients
May 2023
Department for Nervous Diseases, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 119991 Moscow, Russia.
The term neuronutrition has been proposed as part of nutritional neuroscience, studying the effects of various dietary components on behavior and cognition. Other researchers underline that neuronutrition includes the use of various nutrients and diets to prevent and treat neurological disorders. The aim of this narrative review was to explore the current understanding of the term neuronutrition as the key concept for brain health, its potential molecular targets, and perspectives of its nutritional approach to the prevention and treatment of Alzheimer's and Parkinson's diseases, multiple sclerosis, anxiety, depressive disorders, migraine, and chronic pain.
View Article and Find Full Text PDFObjective: To study the effect of the repair stimulator alpha-glutamyl-tryptophan on the morphological characteristics of the gastric mucosa and the expression of CXCL-12 and CDX-2 in chronic atrophic gastritis associated with .
Material And Methods: Biopsy samples of 116 patients with a verified diagnosis of chronic atrophic gastritis associated with were analyzed in a multicenter double-blind randomized placebo-controlled study. During the morphological study, the parameters characterizing the process of atrophy were evaluated: the number of glands per 1 mm of the gastric mucosa, the depth of the gastric mucosa glands, the number of parietal cells per 100 epithelial cells of the gastric mucosa, and the presence of signs of intestinal metaplasia.
JAMA Intern Med
August 2023
Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine at University of California, Los Angeles.
medRxiv
April 2023
Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Importance: Pregnancy induces unique physiologic changes to the immune response and hormonal changes leading to plausible differences in the risk of developing post-acute sequelae of SARS-CoV-2 (PASC), or Long COVID. Exposure to SARS-CoV-2 during pregnancy may also have long-term ramifications for exposed offspring, and it is critical to evaluate the health outcomes of exposed children. The National Institutes of Health (NIH) Researching COVID to Enhance Recovery (RECOVER) Multi-site Observational Study of PASC aims to evaluate the long-term sequelae of SARS-CoV-2 infection in various populations.
View Article and Find Full Text PDFBiomedicines
February 2023
Institute of Biogerontology, Lobachevsky State University of Nizhny Novgorod, 603146 Nizhny Novgorod, Russia.
Background: Kivach Clinic has developed a special medical spa program to prevent aging-related conditions in metabolic, cardio-vascular, and neurological states. Spa programs modify diet, physical activity, and lymphatic drainage, as it deteriorates with aging. We investigated its influence on the blood markers of biological age of patients during their stay to objectify the potential of spa treatment for influencing the risk of age-related events.
View Article and Find Full Text PDFZh Nevrol Psikhiatr Im S S Korsakova
November 2022
National Medical Research Center «Treatment and Rehabilitation Center», Moscow, Russia.
Objective: The analysis of evaluation of the efficacy and safety of Relatox in patients with cervical dystonia (CD).
Material And Methods: Russian multicenter simple comparative randomized clinical trial. The study involved 180 patients of both sexes aged 18-65 years from 3 research centers of the Russian Federation.
Microorganisms
October 2022
R. Gorbacheva Memorial Research Institute of Pediatric Oncology, Hematology and Transplantation, Pavlov University, St. Petersburg 197022, Russia.
Intestinal complications are common after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, only scarce data concern herpesvirus incidence in the colonic mucosa post-HSCT. Our purpose was to assess the frequency and clinical significance of cytomegalovirus (CMV), Epstein−Barr virus (EBV), human herpesvirus type 6 (HHV6), and herpes simplex virus (HSV) in the colonic mucosa post-HSCT.
View Article and Find Full Text PDFSci Rep
November 2022
Intensive Care Unit, Federal Research Clinical Center of Specialized Types of Medical Care and Medical Technologies of the Federal Medical and Biological Agency of Russia, 28 Orekhoviy Blvd, Moscow, 115682, Russia.
Vitamin D as an immunomodulator has not been studied in patients with severe COVID-19. This study aimed to estimate the efficacy of vitamin D3 supplementation on cellular immunity and inflammatory markers in patients with COVID-19 admitted to the intensive care unit (ICU). A single-center, double-blind, randomized, placebo-controlled pilot trial was conducted (N = 110).
View Article and Find Full Text PDFGeorgian Med News
November 2022
4Saint-Petersburg State University, Institute of Translational Biomedicine, Neurobiology and Molecular Pharmacology Laboratory, Saint-Petersburg, Russian Federation.
The drug Prostatilen® AC, rectal suppositories were developed on the basis of the previously registered medicine containing bioregulatory peptides of the prostate gland - Prostatilen® rectal suppositories, 3 mg, from whom it differs by the addition of аctive pharmaceutical ingredient zinc arginyle-glycinate dihydrochloride (ZAG). The aim of this study was to analyze the positive effect of adding ZAG to the drug in patients with impaired spermatogenesis. A total of 98 men aged 25-45 years (an average of 35.
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