2 results match your criteria: "Research Center on Neurology[Affiliation]"
The SNCA-Rep1 Polymorphic Locus: Association with the Risk of Parkinson's Disease and SNCA Gene Methylation.
Acta Naturae
January 2020
Research Center on Neurology, Moscow, 125367 Russia.
Neurodegeneration in Parkinson's disease is characterized by the accumulation of alpha-synuclein, a protein encoded by the gene, in neurons. In addition to mutations, many polymorphisms have been identified in this gene, and one of these is a dinucleotide microsatellite: -Rep1 The mechanisms by which specific configurations of Rep1 may contribute to the development of this disease have yet to be clarified. In our study, a relationship between long Rep1 alleles and Parkinson's was confirmed in the Russian population.
View Article and Find Full Text PDFPresence of lacunar infarctions is associated with the spatial navigation impairment in patients with mild cognitive impairment: a DTI study.
Oncotarget
November 2016
Department of Neurology, The Affiliated Drum Tower Hospital of Nanjing Medical University, Nanjing, Jiangsu, P. R. China.
Article Synopsis
- Lacunar cerebral infarction (LI) is linked to vascular dementia and worsens cognitive impairments, particularly in executive functions.
- A study involving 30 LI patients sought to determine the relationship between spatial navigation ability and white matter integrity in those with mild cognitive impairment (LI-MCI) compared to those without (LI-Non MCI).
- Results showed that LI-MCI patients exhibited greater deficits in spatial navigation tasks and had microstructural abnormalities in areas like the hippocampus that likely contribute to these navigational difficulties.