15 results match your criteria: "Research Center of the Douglas Mental Health University Institute[Affiliation]"
Brain Commun
February 2024
Clinical Memory Research Unit, Faculty of Medicine, Lund University, Malmö 205 02, Sweden.
The accumulation of tau abnormality in sporadic Alzheimer's disease is believed typically to follow neuropathologically defined Braak staging. Recent PET evidence challenges this belief, however, as accumulation patterns for tau appear heterogeneous among individuals with varying clinical expressions of Alzheimer's disease. We, therefore, sought a better understanding of the spatial distribution of tau in the preclinical and clinical phases of sporadic Alzheimer's disease and its association with cognitive decline.
View Article and Find Full Text PDFNetw Neurosci
October 2023
Integrated Program in Neuroscience, Faculty of Medicine, McGill University, Montreal, Canada.
Systematic changes have been observed in the functional architecture of the human brain with advancing age. However, functional connectivity (FC) is also a powerful feature to detect unique "connectome fingerprints," allowing identification of individuals among their peers. Although fingerprinting has been robustly observed in samples of young adults, the reliability of this approach has not been demonstrated across the lifespan.
View Article and Find Full Text PDFJ Psychosoc Oncol
May 2024
Department of Psychoeducation and Psychology, Université du Québec en Outaouais, Gatineau, Canada.
There needs to be a consensus regarding the definition of body image in oncology the literature. This lack of agreement leads to conflicting results in psychosocial interventions aimed to improve body image among breast cancer patients. Through an instrumentalist approach, this systematic review aims to analyze how body image as a concept is described and operationalized in breast cancer studies with the focus to enhance body image through psychosocial interventions.
View Article and Find Full Text PDFSci Rep
August 2023
Department of Neurosciences, Faculty of Medicine, McGill University, Montréal, Canada.
When participants (Pps) are presented with stimuli in the presence of another person, they may consider that person's perspective. Indeed, five recent ERP studies show that the amplitudes of their N400s are increased. The two most recent ones reveal that these social-N400 increases occur even when instructions do not require a focus on the other's perspective.
View Article and Find Full Text PDFmedRxiv
June 2023
Clinical Memory Research Unit, Faculty of Medicine, Lund University, Malmö, 205 02, Sweden.
The spread of tau abnormality in sporadic Alzheimer's disease is believed typically to follow neuropathologically defined Braak staging. Recent positron emission tomography (PET) evidence challenges this belief, however, as spreading patterns for tau appear heterogenous among individuals with varying clinical expression of Alzheimer's disease. We therefore sought better understanding of the spatial distribution of tau in the preclinical and clinical phases of sporadic Alzheimer's disease and its association with cognitive decline.
View Article and Find Full Text PDFFront Psychiatry
November 2022
Research Center of the Douglas Mental Health University Institute (CIUSSS-ODIM), Montreal, QC, Canada.
Epigenetic research in post-traumatic stress disorder (PTSD) is essential, given that environmental stressors and fear play such a crucial role in its development. As such, it may provide a framework for understanding individual differences in the prevalence of the disorder and in treatment response. This paper reviews the epigenetic markers associated with PTSD and its treatment, including candidate genes and epigenome-wide studies.
View Article and Find Full Text PDFJ Affect Disord
November 2022
Research Center of the Douglas Mental Health University Institute, Montreal, Québec, Canada; McGill University, Department of Psychiatry, Montreal, Québec, Canada. Electronic address:
Objectives: In a sustained relationship, romantic betrayal is a catastrophic event that can precipitate an adjustment disorder (AD). Surprisingly, there exists no empirically validated treatment for AD, despite its high prevalence in clinical practice. Considering the promise of memory reactivation under propranolol (i.
View Article and Find Full Text PDFStress Health
February 2023
Research Center of the Douglas Mental Health University Institute, Verdun, Quebec, Canada.
The Peritraumatic Distress Inventory (PDI) is a well-known self-report questionnaire indexing the distress experienced during and shortly after a most stressful or traumatic event. Although sociodemographic factors contributing to peritraumatic distress have been previously investigated, no research has examined the nature and severity of peritraumatic distress reactions in a non-clinical, community sample as a function of age. An international sample of 5621 adult participants were grouped according the World Health Organization's age stratification protocol.
View Article and Find Full Text PDFBMC Psychiatry
April 2022
Research Center of the Douglas Mental Health University Institute (CIUSSS-ODIM), 6875 boulevard LaSalle, Montreal, QC, H4H 1R3, Canada.
Br J Cancer
November 2021
Psychosocial Research Division, Research Center of the Douglas Mental Health University Institute, Verdun, QC, Canada.
Neuropsychopharmacology
January 2018
Department of Pharmacology, University of Washington School of Medicine, Seattle, WA, USA.
The dynorphin/κ-opioid receptor (KOR) system has been previously implicated in the regulation of cognition, but the neural circuitry and molecular mechanisms underlying KOR-mediated cognitive disruption are unknown. Here, we used an operational test of cognition involving timing and behavioral inhibition and found that systemic KOR activation impairs performance of male and female C57BL/6 mice in the differential reinforcement of low response rate (DRL) task. Systemic KOR antagonism also blocked stress-induced disruptions of DRL performance.
View Article and Find Full Text PDFInt J Environ Res Public Health
May 2016
Centre for Population Health Research, School of Health Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide SA 5001, Australia.
Understanding how health outcomes are spatially distributed represents a first step in investigating the scale and nature of environmental influences on health and has important implications for statistical power and analytic efficiency. Using Australian and French cohort data, this study aimed to describe and compare the extent of geographic variation, and the implications for analytic efficiency, across geographic units, countries and a range of cardiometabolic parameters (Body Mass Index (BMI) waist circumference, blood pressure, resting heart rate, triglycerides, cholesterol, glucose, HbA1c). Geographic clustering was assessed using Intra-Class Correlation (ICC) coefficients in biomedical cohorts from Adelaide (Australia, n = 3893) and Paris (France, n = 6430) for eight geographic administrative units.
View Article and Find Full Text PDFJ Behav Ther Exp Psychiatry
March 2016
Research Center of the Douglas Mental Health University Institute, 6875 boul. Lasalle, Montreal, Qc, H4H 1R3, Canada; Department of Psychiatry, McGill University, Ludmer Research & Training Bldg., 1033 Pine Ave. West, Montreal, Qc, H3A 1A1, Canada. Electronic address:
Background: The reconsolidation blocker propranolol abolishes alcohol and drug-seeking behavior in rodents and attenuates conditioned emotional responses to drug-cues in humans in experimental settings. This suggests a role for its use in the treatment of substance dependence. In this translational pilot study, we explored the feasibility and efficacy of this procedure as an adjunct treatment for addiction.
View Article and Find Full Text PDFPLoS One
September 2013
Research Center of the Douglas Mental Health University Institute, Montreal, Quebec, Canada.
Background: With the release of the H1N1 vaccine, there was much controversy surrounding its use despite strong encouragements to be vaccinated in the media. Though studies have examined factors influencing people's decision to be vaccinated, few have focused on how general beliefs about the world or where an individual gathers information might influence that decision.
Methodology/principal Findings: A cross-sectional web-based survey (N = 817) was conducted during the H1N1 outbreak after the vaccine was available.
Eur Neuropsychopharmacol
May 2013
Research Center of the Douglas Mental Health University Institute, Montréal, Québec, Canada.
Delusions and hallucinations are often meaningful. They thus reveal abnormal semantic activations. To start testing whether antipsychotics act by reducing abnormal semantic activations we focused on the N400 event-related brain potential, which is elicited by meaningful stimuli, such as words, and whose distribution on the scalp is known to depend on the semantic category of these stimuli.
View Article and Find Full Text PDF