Lucidin from Outperforms FDA-Approved Lapatinib as a Potential Multitargeted Candidate for Breast Cancer Signalling Proteins.

Breast cancer remains a significant global health concern, with approximately 2.3 million diagnosed cases and 670,000 deaths annually. Current targeted therapies face challenges such as resistance and adverse side effects.

Nose-to-Brain Delivery of Chitosan-Grafted Leciplexes for Promoting the Bioavailability and Antidepressant Efficacy of Mirtazapine: In Vitro Assessment and Animal Studies.

: Mirtazapine (MRZ) is a psychotropic drug prescribed to manage serious sorts of depression. By virtue of its extensive initial-pass metabolic process with poor water solubility, the ultimate bioavailability when taken orally is a mere 50%, necessitating repeated administration. The current inquiry intended to fabricate nose-to-brain chitosan-grafted cationic leciplexes of MRZ (CS-MRZ-LPX) to improve its pharmacokinetic weaknesses and boost the pharmacodynamics aspects.

Multi-Omics Analysis in Mouse Primary Cortical Neurons Reveals Complex Positive and Negative Biological Interactions Between Constituent Compounds of .

A water extract of the Ayurvedic plant (L.) Urban, family Apiaceae (CAW), improves cognitive function in mouse models of aging and Alzheimer's disease and affects dendritic arborization, mitochondrial activity, and oxidative stress in mouse primary neurons. Triterpenes (TT) and caffeoylquinic acids (CQA) are constituents associated with these bioactivities of CAW, although little is known about how interactions between these compounds contribute to the plant's therapeutic benefit.

Assessment of Antibiotic Resistance Among Isolates of spp. and spp. in Wildlife and Their Environment from Portugal: A Positive Epidemiologic Outcome.

One of the significant challenges facing modern medicine is the rising rate of antibiotic resistance, which impacts public health, animal health, and environmental preservation. Evaluating antibiotic resistance in wildlife and their environments is crucial, as it offers essential insights into the dynamics of resistance patterns and promotes strategies for monitoring, prevention, and intervention. and genera isolates were recovered from fecal samples of wild animals and environmental samples using media without antibiotic supplementation.

Inverted Patterns of Schistosomiasis and Fascioliasis and Risk Factors Among Humans and Livestock in Northern Tanzania.

Fascioliasis and schistosomiasis are parasitic trematodiases of public health and economic concern in humans and livestock. However, data on the distribution and risk factors for fascioliasis remain limited, while epidemiological gaps hinder schistosomiasis control in Tanzania. This One Health, cross-sectional study examined the prevalence and risk factors of schistomiasis and fascioliasis in northern Tanzania, involving 310 livestock and 317 human participants from Arusha, Kilimanjaro, and Manyara regions.

Integrating Remote Sensing and Soil Features for Enhanced Machine Learning-Based Corn Yield Prediction in the Southern US.

Efficient and reliable corn ( L.) yield prediction is important for varietal selection by plant breeders and management decision-making by growers. Unlike prior studies that focus mainly on county-level or controlled laboratory-scale areas, this study targets a production-scale area, better representing real-world agricultural conditions and offering more practical relevance for farmers.

Distributed Fiber Optic Strain Sensing Technology for Monitoring Soil Deformation Induced by Leakage in Buried Water Pipelines: A Model Test Study.

Water pipelines in water diversion projects can leak, leading to soil deformation and ground subsidence, necessitating research into soil deformation monitoring technology. This study conducted model tests to monitor soil deformation around leaking buried water pipelines using distributed fiber optic strain sensing (DFOSS) technology based on optical frequency domain reflectometry (OFDR). By arranging strain measurement fibers in a pipe-soil model, we investigated how leak location, leak size, pipe burial depth, and water flow velocity affect soil strain field monitoring results.

Dialysis Patients' Evaluation of Lung Edema at Home Using a Mobile Phone Tele-Ultrasound Application: A Pilot Study.

: Home rehabilitation improves patient satisfaction and reduces the need for specialist consultations. Hemodialysis is a costly post-ICU service that requires frequent monitoring. Previous studies have demonstrated the feasibility and accuracy of patients self-scanning their lungs with an ultrasound device within the hospital.

Prevention and Management of Postoperative Infection After Anterior Cruciate Ligament Reconstruction: A Narrative Review.

: Postoperative infection following anterior cruciate ligament reconstruction (ACLR) is a rare yet severe complication that can compromise patient outcomes, leading to prolonged recovery, graft failure, and knee dysfunction. Although infection rates are reported to be less than 2%, it remains essential to implement strategies to reduce infection risk and improve surgical outcomes. : This review explores current evidence on the prevention of infections in ACLR, emphasizing the importance of timely antibiotic prophylaxis and vancomycin presoaking of grafts, which has been associated with a substantial reduction in infection rates.

Mechanistic Insights into the Anticancer Potential of Methoxyflavones Analogs: A Review.

2-phenylchromen-4-one, commonly known as flavone, plays multifaceted roles in biological response that can be abundantly present in natural sources. The methoxy group in naturally occurring flavones promotes cytotoxic activity in various cancer cell lines by targeting protein markers, in facilitating ligand-protein binding mechanisms and activating cascading downstream signaling pathways leading to cell death. However, the lipophilic nature of these analogs is a key concern as it impacts drug membrane transfer.

Electron Push-Pull Effect of Benzotrithiophene-Based Covalent Organic Frameworks on the Photocatalytic Degradation of Pharmaceuticals and Personal Care Products.

A covalent organic framework (COF) has emerged as a promising photocatalyst for the removal of pharmaceutical and personal care product (PPCP) contaminants; however, high-performance COF photocatalysts are still scarce. In this study, three COF photocatalysts were successfully synthesized by the condensation of benzo[1,2-b:3,4-b':5,6-b'']trithiophene-2,5,8-tricarbaldehyde (BTT) with 4,4',4''-(1,3,5-triazine-2,4,6-triyl)trianiline (TAPT), 1,3,5-Tris(4-aminophenyl)benzene (TAPB), and 4,4',4''-nitrilotris(benzenamine) (TAPA), namely, BTT-TAPA, BTT-TAPB, and BTT-TAPT, respectively. The surface areas of BTT-TAPA, BTT-TAPB, and BTT-TAPT were found to be 800.

A Study on the Mechanism of Cellulose Nanocrystals to Enhance the Stability of Hydrophobic Phthalocyanine Green in Water and the Functional Characteristics of Colour Pastes.

Cellulose nanocrystals (CNCs) prepared by sulfuric acid hydrolysis were added to phthalocyanine green colour pastes with a surfactant to improve stability. The particle size, zeta potential, absorbance, and microstructure of the colour pastes were analyzed and characterized. The mechanism of CNCs to enhance the stability of hydrophobic phthalocyanine green in water was investigated.

Novel Intravenous Nanoemulsions Based on Cannabidiol-Enriched Hemp Oil-Development and Validation of an HPLC-DAD Method for Cannabidiol Determination.

Background: Intravenous nanoemulsions (NEs) are gaining attention as potential delivery systems for poorly water-soluble substances like cannabidiol (CBD). This study aimed to develop novel NEs based on CBD-enriched hemp oils and evaluate their physiochemical properties.

Methods: The stability of hemp oils enriched with various concentrations of CBD (0.

Maximizing H Production from a Combination of Catalytic Partial Oxidation of CH and Water Gas Shift Reaction.

A single-bed and dual-bed catalyst system was studied to maximize H production from the combination of partial oxidation of CH and water gas shift reaction. In addition, the different types of catalysts, including Ni, Cu, Ni-Re, and Cu-Re supported on gadolinium-doped ceria (GDC) were investigated under different operating conditions of temperature (400-650 °C). Over Ni-based catalysts, methane can easily dissociate on a Ni surface to give hydrogen and carbon species.

g-CN Modified with Metal Sulfides for Visible-Light-Driven Photocatalytic Degradation of Organic Pollutants.

Graphitic carbon nitride (g-CN) proved to be a promising semiconductor for the photocatalytic degradation of various organic pollutants. However, its efficacy is limited by a fast electron hole recombination, a restricted quantity of active sites, and a modest absorption in the visible range. To overcome these limitations, g-CN-BiS and g-CN-ZnS composites were effectively produced utilizing a starch-assisted technique.

Development of Homogeneous Carboxylation of Phenolates via Kolbe-Schmitt Reaction.

In this study, the homogeneous carboxylation of potassium, sodium, and lithium phenolates in DMSO solution at 100 °C by the Kolbe-Schmitt reaction was investigated. The impact of water, phenolate concentration, and cation nature on the yield of products and reaction selectivity was demonstrated. Based on the patterns observed, it was concluded that a complex cluster mechanism governs the carboxylation reaction in the solution.

Synthesis and Advanced NMR Characterization of Ordered 3D Reticular Materials with PolySilicate Nodes and Hydrophobic OrganoSilicone Linkers.

This work describes the synthesis of ordered 3D siloxane-silsesquioxane reticular materials with silicate D4R cubes (SiO), harvested from a sacrificial tetrabutylammonium cyclosilicate hydrate (TBA-CySH) precursor, interlinked with octyl and dicyclopentyl (Cp) hydrocarbon functionalities in a one-step synthesis with organodichlorosilanes. Advanced solid-state NMR spectroscopy allowed us to unravel the molecular order of the nodes and their interconnection by the silicone linkers. In the case of octyl-methyl silicone linkers, changing the silane-to-silicate ratio in the synthesis allowed for tuning the length of the linker between the nodes.

Characterization and Otoprotective Effects of Polysaccharides from .

Hearing loss is one of the most common sensory disorders in humans, and a large number of cases are due to ear cell damage caused by ototoxic drugs including anticancer agents, such as cisplatin. The recent literature reported that hearing loss is promoted by an excessive generation of reactive oxygen species (ROS) in cochlea cells, which causes oxidative stress. Recently, polysaccharides from the cyanobacterium showed many biological activities, including antioxidant activity, suggesting their potential use to combat hearing loss.

Research on the Aging Characteristics of Simulated Asphalt Within Pavement Structures in Natural Environments.

The global asphalt production growth rate exceeded 10% in the past decade, and over 90% of the world's road surfaces are generated from asphalt materials. Therefore, the issue of asphalt aging has been widely researched. In this study, the aging of asphalt thin films under various natural conditions was studied to prevent the distortion of indoor simulated aging and to prevent the extraction of asphalt samples from road surfaces from impacting the aged asphalt.

Construction and Properties of Wood-Based Tannin-Iron-Complexed Photothermal Material .@Fe-GA for Solar Seawater Desalination System.

Desalinating seawater is a crucial method for addressing the shortage of freshwater resources. High-efficiency, low-cost, and environmentally friendly desalination technologies are key issues that urgently need to be addressed. This work used as a matrix material and prepared @Fe-GA through a complexation reaction to enhance the water evaporation rate and photothermal conversion efficiency of seawater desalination.

Stability and Rheological Properties of Grouts with Waste Glass Powder as Cement Replacement: Influences of Content and Alkali Activator.

Effective recycling and utilization of waste glass is a critical issue that urgently needs to be addressed. This study aims to explore the feasibility of using ground waste glass powder (particle size ≤ 75 μm) as a supplementary cementitious material to partially replace cement in the preparation of low-carbon and environmentally friendly grouting materials. The research systematically evaluates the impact of waste glass powder (WGP) on the fresh properties (particularly the stability and rheological characteristics) of cement-based grouting materials under various conditions, including WGP content (0-40%), the addition of NaOH activator (NaO content of 4%) or not, and water-solid ratio (/ 0.

Macronutrient-Based Predictive Modelling of Bioconversion Efficiency in Black Soldier Fly Larvae () Through Artificial Substrates.

This study explores the optimisation of rearing substrates for black soldier fly larvae (BSFL). First, the ideal dry matter content of substrates was determined, comparing the standard 30% dry matter (DM) with substrates hydrated to their maximum water holding capacity (WHC). Substrates at maximal WHC yielded significantly higher larval survival rates ( = 0.

Impact of Comb Cell Diameter on Nectar Evaporation Efficiency in Honey Bees.

Honey bees transform nectar into honey through a combination of physical and chemical processes, with the physical process primarily involving the evaporation of excess water to concentrate the nectar. However, the factors affecting evaporation efficiency, such as evaporation duration, cell type, and bee species, remain incompletely understood. This study aimed to examine how these factors affect nectar evaporation efficiency during honey production.

Bioconversion of Poultry Litter into Insect Meal and Organic Frasstilizer Using Black Soldier Fly Larvae as a Circular Economy Model for the Poultry Industry: A Review.

Poultry litter waste management poses a significant global challenge, attributed to its characteristics (odorous, organic, pathogenic, attracting flies). Conventional approaches to managing poultry litter involve composting, biogas generation, or direct field application. Recently, there has been a surge of interest in a novel technology that involves the bioconversion of organic waste utilizing insects (known as entomoremediation), particularly focusing on black soldier fly larvae (BSFL), and has demonstrated successful transformation of various organic waste materials into insect meal and frass (referred to as organic frasstilizer).

Marine-Derived Polysaccharide Hydrogels as Delivery Platforms for Natural Bioactive Compounds.

Marine polysaccharide hydrogels have emerged as an innovative platform for regulating the in vivo release of natural bioactive compounds for medical purposes. These hydrogels, which have exceptional biocompatibility, biodegradability, and high water absorption capacity, create effective matrices for encapsulating different bioactive molecules. In addition, by modifying the physical and chemical properties of marine hydrogels, including cross-linking density, swelling behavior, and response to external stimuli like pH, temperature, or ionic strength, the release profile of encapsulated bioactive compounds is strictly regulated, thus maximizing therapeutic efficacy and minimizing side effects.