Challenging Structure Elucidation of Lumnitzeralactone, an Ellagic Acid Derivative from the Mangrove .

The previously undescribed natural product lumnitzeralactone (), which represents a derivative of ellagic acid, was isolated from the anti-bacterial extract of the Indonesian mangrove species Willd. The structure of lumnitzeralactone (), a proton-deficient and highly challenging condensed aromatic ring system, was unambiguously elucidated by extensive spectroscopic analyses involving high-resolution mass spectrometry (HRMS), 1D H and C nuclear magnetic resonance spectroscopy (NMR), and 2D NMR (including 1,1-ADEQUATE and 1,n-ADEQUATE). Determination of the structure was supported by computer-assisted structure elucidation (CASE system applying ACD-SE), density functional theory (DFT) calculations, and a two-step chemical synthesis.

The Antibacterial and Antibiofilm Activities of the Endophytic Bacteria Associated with Archidendron pauciflorum against Multidrug-Resistant Strains.

Endophytes associated with medicinal plants are a potential source of valuable natural products. This study aimed to evaluate the antibacterial and antibiofilm activities of endophytic bacteria from Archidendron pauciflorum against multidrug-resistant (MDR) strains. A total of 24 endophytic bacteria were isolated from the leaf, root, and stem of A.

Current trends and future perspective of probiotic yeasts research in Indonesia.

Indonesia is a mega biodiversity country with various local wisdom, including the enormous variety of fermented foods and beverages. Indonesian researchers have conducted an intensive study to understand the diversity of microbes on those fermented products, one of which shows probiotic properties. Compared to that lactic acid bacteria, the study on probiotic yeasts is less explored.

Immunoinformatics Study: Multi-Epitope Based Vaccine Design from SARS-CoV-2 Spike Glycoprotein.

The coronavirus disease 2019 outbreak has become a huge challenge in the human sector for the past two years. The coronavirus is capable of mutating at a higher rate than other viruses. Thus, an approach for creating an effective vaccine is still needed to induce antibodies against multiple variants with lower side effects.

Characterization of seahorse ( L.) extracts originating from culture and nature in Pesawaran, Lampung, Indonesia.

Objective: Indonesia is an archipelagic country with a mega biodiversity, among others, in the marine area. Seahorses ( spp.) are a marine fish known to have biocompounds used in traditional medicine "Jamu," such as L.

Thiolated pectin-chitosan composites: Potential mucoadhesive drug delivery system with selective cytotoxicity towards colorectal cancer.

Mucoadhesive drug delivery systems (DDS) may promote safer chemotherapy for colorectal cancer (CRC) by maximizing local drug distribution and residence time. Carbohydrate polymers, e.g.

Culturable endophytic fungal assemblages from and and their potential as antifungal, antioxidant, and alpha-glucosidase inhibitory resources.

Benzoin resin, produced by the native Indonesian trees and , has been incorporated into medical practices to treat wounds, erythema, and many other conditions for centuries. Endophytic fungi that reside within medicinal plants have antimicrobial, antioxidant, and α-glucosidase inhibitory capacities, contributing to plant health and derivative products. In this study, we determined the antifungal, antioxidant, and α-glucosidase inhibitory capacities of endophytic fungal isolates from three different tissues (leaves, bark, and stems) of and trees.

Immunomodulatory Effects of Combined Ethanol Extracts of and on Cellular- and Humoral-Mediated Immunity in Wistar Rats and Mice.

Previous studies have shown that the extracts of Valeton & Zijp rhizomes and Lour. leaves could modulate cellular- and humoral-mediated immunity in macrophages and animal models. In the present study, the immunomodulatory effects of combined ethanol extracts of rhizomes and leaves were investigated on cellular- and humoral-mediated immunity in Wistar rats and mice.

Anti-inflammatory and antioxidant activities of methanol extract of Piper betle Linn. (Piper betle L.) leaves and stems by inhibiting NF-κB/MAPK/Nrf2 signaling pathways in RAW 264.7 macrophages.

Oxidative stress and chronic inflammation are closely linked to various diseases. However, previous studies have demonstrated that plant extracts could prevent and alleviate these adverse outcomes. Piper betle Linn.

Magnetic Graphene-Based Nanosheets with Pluronic F127-Chitosan Biopolymers Encapsulated α-Mangosteen Drugs for Breast Cancer Cells Therapy.

In this study, multifunctional chitosan-pluronic F127 with magnetic reduced graphene oxide (MRGO) nanocomposites were developed through the immobilization of chitosan and an amphiphilic polymer (pluronic F127) onto the MRGO. Physicochemical characterizations and in-vitro cytotoxicity of nanocomposites were investigated through field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy, particle size analysis, vibrating sample magnetometer, Raman spectroscopy and resazurin-based in-vitro cytotoxicity assay. FESEM observation shows that the magnetic nanoparticles could tethered on the surface of MRGO, promoting the magnetic properties of the nanocomposites.

Reduced graphene oxide nanosheets decorated with core-shell of FeO-Au nanoparticles for rapid SERS detection and hyperthermia treatment of bacteria.

In this study, the core-shell of FeO-Au nanoparticles (NPs) were prepared by seeding AuNPs onto FeO NPs modified with poly-ethylenimine (PEI). Later, FeO-Au NPs were attached to cationic poly(dimethyldiallylammonium chloride) (PDDA)-modified graphene oxide (GO) nanosheets through in situ self-assembly behaviors, termed as FeO-Au@RGO nanocomposites, for surface-enhanced Raman scattering (SERS) detection and hyperthermia treatment of bacteria. The resulting FeO-Au@RGO nanocomposites were evaluated systematically by transmission electron microscope, zeta potential, X-ray diffraction, X-ray photoelectron spectroscopy, and vibrating sample magnetometer.