Human Brucellosis among the farmworkers in Cilawu and Boyolali, Indonesia.

Brucellosis is a neglected infectious disease caused by animals and is becoming a public health problem in developing countries. There are limited case reports of human brucellosis in Indonesia because the symptoms are not specific. This study investigated the association between serological tests for brucellosis among workers and their knowledge, attitude, and behavior.

A bibliometric analysis of biopesticides in corn pest management: Current trends and future prospects.

This bibliographic review paper presents a comprehensive analysis of the scholarly literature on biopesticides utilized in corn pest management, employing a bibliometric approach to identify current trends and prospects in the field. The growing demand for sustainable agricultural practices has fueled interest in biopesticides as effective alternatives to conventional chemical pesticides. By systematically examining relevant publications, this review synthesizes the collective knowledge on biopesticide applications in corn production, encompassing various types of biopesticides, their modes of action, efficacy against key corn pests, and environmental considerations.

Quercetin as a therapeutic agent for skin problems: a systematic review and meta-analysis on antioxidant effects, oxidative stress, inflammation, wound healing, hyperpigmentation, aging, and skin cancer.

Quercetin is abundant in plants and has notable pharmacological properties for skin health. This review aims to comprehensively evaluate the effects of quercetin on skin-related issues, adhering to the PRISMA guidelines and analyzing studies from ScienceDirect, Web of Science, Scopus, and PubMed. Of the 1,398 studies identified, 65 studies met the criteria for meta-analysis.

Bovine trichomoniasis: A hidden threat to reproductive efficiency.

Bovine trichomoniasis is a reproductive illness that affects cattle causing pyometra, early to mid-pregnancy miscarriages, and lower birth rates. is a flagellated protozoan which first discovered in France in 1888 and composts three phases during its lifecycle including trophozoite, cyst, and pseudocyst. In addition, several factors contributed to the prevalence of trichomoniasis and fall into three categories are management, cow, and bull-related factors.

Plant Endophytic Fungi: Powerful Catalytic Cells for Biotransformation of Chemical Structures of Biologically Active Compounds.

Fungal endophytes are recognized as an essential source of bioactive compounds. Besides producing a wide variety of compounds, fungal endophytes can also facilitate a biotransformation process. In this process, endophytes act as an enzyme source to catalyze chemical reactions and modify the structures of bioactive compounds.

Two Strains of Endophytic Carrying Antibiotic-Biosynthetic Genes Show Antibacterial and Antibiofilm Activities Against Methicillin-Resistant (MRSA).

Unlabelled: Methicillin-resistant (MRSA) is considered a priority pathogen causing high mortality that requires effective control measures. This study aimed to detect the presence of antibiotic-biosynthetic genes and to evaluate the anti-MRSA activity of two strains of endophytic isolated from . PCR-based screening showed that strains, such as DJ4 and DJ9 possessed six antibiotic-biosynthetic genes, namely , and According to the preliminary test conducted using disc-diffusion assay, metabolite extracts from these strains have anti-MRSA activity with clear zone diameters of 13.

Network pharmacology and bioinformatic integrative analysis reveals candidate gene targets and potential therapeutic of East Kalimantan propolis against hepatocellular carcinoma.

Introduction: Hepatocellular Carcinoma (HCC) is commonly treated with surgery, liver transplantation, and chemotherapy, but recurrence and metastasis remain challenges. Natural complementary therapies like propolis, known for its hepatoprotective properties, are gaining interest due to limited efficacy and toxicity of conventional chemotherapy. This study aims to identify core targets for HCC, assess the therapeutic potential of East Kalimantan propolis (EKP) from stingless bees, and analyze the molecular interactions.

NMR-based metabolic profiling and antioxidant activity of ethanol extract.

The metabolite profile of the ethanol extract from was assessed using the 1D NMR approach amalgamated with 2D NMR. an indigenous plant found in Indonesia, possesses considerable promise as a raw material for medicinal products. We examined the antioxidant capacity of the extract using DPPH and ABTS methods.

Antimalarial activity of borrelidin and fumagilin in -infected mice.

Background: Malaria remains a significant global health burden, with drug resistance posing a major challenge to its control. The emergence of resistance to antimalarial drugs represents a critical issue in malaria management, as it heightens the likelihood of morbidity and mortality associated with the disease. There is an urgent requirement for a novel candidate drug with a distinct mechanism of action.

Characteristics of Indonesian Stingless Bee Propolis and Study of Metabolomic Properties Based on Region and Species.

The chemical compounds found in propolis vary according to plant sources, species, and geographical regions. To date, Indonesian propolis has not yet become standardized in terms of its chemical constituents. Thus, this study aimed to identify the presence of marker compounds and determine whether different classes of Indonesian propolis exist.

Unveiling the anti-obesity potential of Kemuning (Murraya paniculata): A network pharmacology approach.

Obesity has become a global issue that affects the emergence of various chronic diseases such as diabetes mellitus, dysplasia, heart disorders, and cancer. In this study, an integration method was developed between the metabolite profile of the active compound of Murraya paniculata and the exploration of the targeting mechanism of adipose tissue using network pharmacology, molecular docking, molecular dynamics simulation, and in vitro tests. Network pharmacology results obtained with the skyline query technique using a block-nested loop (BNL) showed that histone acetyltransferase p300 (EP300), peroxisome proliferator-activated receptor gamma (PPARG), and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) are potential targets for treating obesity.

Recent updates in applications of nanomedicine for the treatment of hepatic fibrosis.

Over recent decades, nanomedicine has played an important role in the enhancement of therapeutic outcomes compared to those of conventional therapy. At the same time, nanoparticle drug delivery systems offer a significant reduction in side effects of treatments by lowering the off-target biodistribution of the active pharmaceutical ingredients. Cancer nanomedicine represents the most extensively studied nanotechnology application in the field of pharmaceutics and pharmacology since the first nanodrug for cancer treatment, liposomal doxorubicin (Doxil), has been approved by the FDA.

Exploring Indonesian actinomycete extracts for anti-tubercular compounds: Integrating inhibition assessment, genomic analysis, and prediction of its target by molecular docking.

Tuberculosis (TB) is the foremost cause of infectious fatality globally. The primary global challenge in combatting TB lies in addressing the emergence of drug-resistant variants of the disease. However, the number of newly approved agents for treating TB has remained remarkably low over recent decades.

Developing zinc oxide and peanut shell-derived carbon star-shaped composite materials for effective photo-antibacterial treatment.

The development of new carbon-based materials using natural biowaste for biomedical applications has remained a significant challenge in the past decades. In this study, we successfully synthesized and characterized composite materials made from peanut shell-derived carbon (PNS-C) decorated on ZnO that formed star-shaped particles via a simple hydrothermal technique. The as-prepared composites possess several advantages, including unique optical properties and high photostability.

Vitamin D status, vitamin D receptor, CYP2R1, and CYP24A1 profiles in children.

Introduction: Vitamin D plays a major role in the musculoskeletal and immune system. Understanding the comprehensive mechanism of vitamin D receptors and the enzyme of vitamin D induction (CYP2R1) and inhibition (CYP24A1) in its metabolism is interesting. This study aims to understand vitamin D metabolism in Indonesian pediatrics, specifically in Jakarta, which has abundant sun exposure.

Unveiling green corrosion inhibitor of Aloe vera extracts for API 5L steel in seawater environment.

This study evaluated Aloe vera extract as a green inhibitor to prevent corrosion in seawater environments. A. vera extract was produced by maceration with methanol-water at room temperature.

Innovative surfactant-free synthesis of core-shell SiO/ZnO particles: rapid ultrasonication and photocatalytic inhibition.

This study demonstrates the preparation of SiO/ZnO core-shell nanoparticles with controllable shell size and their optical properties. A facile ultrasonication method was utilized to prepare the core-shell particles in the absence of surfactant materials. The synthesis duration was 75% shorter than that required for the common sol-gel method, which favours its potential applicability in the future for mass production.

Gene expression profiling of vitamin D metabolism enzymes in leukemia and lymphoma patients: molecular aspect interplay of VDR, CYP2R1, and CYP24A1.

Background: Vitamin D deficiency is prevalent among the Indonesian population, particularly in individuals diagnosed with leukemia-lymphoma. The regulation of vitamin D metabolism is influenced by the expression of several enzymes, such as CYP2R1, CYP24A1, and the vitamin D receptor (VDR). This study aimed to scrutinize the gene expression profiles in both mRNA and protein levels of VDR, CYP2R1, and CYP24A1 in leukemia and lymphoma patients.

Mechanistic insights into anti-inflammatory and immunosuppressive effects of plant secondary metabolites and their therapeutic potential for rheumatoid arthritis.

The anti-inflammatory and immunosuppressive activities of plant secondary metabolites are due to their diverse mechanisms of action against multifarious molecular targets such as modulation of the complex immune system associated with rheumatoid arthritis (RA). This review discussed and critically analyzed the potent anti-inflammatory and immunosuppressive effects of several phytochemicals and their underlying mechanisms in association with RA in experimental studies, including preliminary clinical studies of some of them. A wide range of phytochemicals including phenols, flavonoids, chalcones, xanthones, terpenoids, alkaloids, and glycosides have shown significant immunosuppressive and anti-inflammatory activities in experimental RA models and a few have undergone clinical trials for their efficacy and safety in reducing RA symptoms and improve patient outcomes.

Molecular detection and identification of spp. isolated from captive-bred cynomolgus monkeys in Bogor, Indonesia.

Background And Aim: Asian macaques are natural hosts of several species. Some monkey malaria parasites may infect humans and cause zoonotic infections. This study was conducted to estimate the prevalence of monkey malaria parasites in Bogor, Indonesia, based on molecular detection and identification, particularly in cynomolgus monkeys, which have a wide geographic distribution and share extensive habitats with humans.

Phytochemical Profile, Antioxidant, Enzyme Inhibition, Acute Toxicity, In Silico Molecular Docking and Dynamic Analysis of Apis Mellifera Propolis as Antidiabetic Supplement.

This study aims to identify the phytochemical profile of Apis mellifera propolis and explore the potential of its anti-diabetic activity through inhibition of α-amylase (α-AE), α-glucosidase(α-GE), as well as novel antidiabetic compounds of propolis. Apis mellifera propolis extract (AMPE) exhibited elevated polyphenol 33.26±0.

Acute and Subchronic Toxicological Study of the Cocktail Extract from Roxb, L. and L.

Roxb L., and L. are Indonesian medicinal herbs used empirically as traditional therapeutics for maintaining health.