Investigation of HIV-1 Viral Protein R Inhibitory Activities of Twelve Thai Medicinal Plants and Their Commercially Available Major Constituents.

Viral protein R (Vpr) is an accessory protein in Human immunodeficiency virus-1 (HIV-1) and has been suggested as an attractive target for HIV disease treatment. Investigations of the ethanolic extracts of twelve Thai herbs revealed that the extracts of the Punica granatum fruits, the Centella asiatica aerials, the Citrus hystrix fruit peels, the Caesalpinia sappan heartwoods, the Piper betel leaves, the Alpinia galangal rhizomes, the Senna tora seeds, the Zingiber cassumunar rhizomes, the Rhinacanthus nasutus leaves, and the Plumbago indica roots exhibited the anti-Vpr activity in HeLa cells harboring the TREx plasmid encoding full-length Vpr (TREx-HeLa-Vpr cells). Moreover, the investigation of the selected main constituents in Punica granatum, Centella asiatica, A.

Antiaging and Antioxidant Bioactivities of Asteraceae Plant Fractions on the Cellular Functions of the Yeast .

Research on antioxidants has been gaining worldwide attention because of their essential applications for medicinal purposes. In this study, we conducted bioprospecting of six Asteraceae plants as the source of antiaging and antioxidant agents. Water and chloroform fractions from L.

Genome-Resolved Meta-Analysis of the Microbiome in Oil Reservoirs Worldwide.

Microorganisms inhabiting subsurface petroleum reservoirs are key players in biochemical transformations. The interactions of microbial communities in these environments are highly complex and still poorly understood. This work aimed to assess publicly available metagenomes from oil reservoirs and implement a robust pipeline of genome-resolved metagenomics to decipher metabolic and taxonomic profiles of petroleum reservoirs worldwide.

Pyrolysis of cajuput () twigs and rice () husks to produce liquid smoke-containing fine chemicals for antibacterial agent application.

Pyrolysis of cajuput () twigs and rice () husks to produce liquid smoke and antibacterial activities of the liquid smoke fractions were investigated. The liquid smoke was produced by pyrolysis at 500 °C for 8 h and contained fine chemicals, such as acetic acid, carbonyl, cyclic ketones, and phenolic compounds with pH 2.1-2.

Self-Assembled Behavior of Ultralightweight Aerogel from a Mixture of CNC/CNF from Oil Palm Empty Fruit Bunches.

This study aims to explore the use of cellulose nanocrystals (CNC) and cellulose nanofiber (CNF), obtained from unbleached fiber of oil palm empty fruit bunches (EFB), as raw materials in fabricating aerogel, using the facile technique without solvent displacement. The CNC was isolated from sulfuric acid hydrolysis, and the CNF was fibrillated using Ultra Turrax. The CNC and CNF were mixed by ultrasonication in different ratios to produce aerogel using slow freezing (-20 °C), followed by freeze-drying.

New Trends in Diaziridine Formation and Transformation (a Review).

This review focuses on diaziridine, a high strained three-membered heterocycle with two nitrogen atoms that plays an important role as one of the most important precursors of diazirine photoaffinity probes, as well as their formation and transformation. Recent research trends can be grouped into three categories, based on whether they have examined non-substituted, -monosubstituted, or ,-disubstituted diaziridines. The discussion expands on the conventional methods for recent applications, the current spread of studies, and the unconventional synthesis approaches arising over the last decade of publications.

Photothermal therapy mediated by gold nanocages composed of anti-PDL1 and galunisertib for improved synergistic immunotherapy in colorectal cancer.

Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. The primary treatment for CRC is surgical resection, along with chemotherapy in more advanced or inoperable cases. There is a growing interest to complement both curative and palliative treatment with immunotherapies such as the programmed cell death-1 (PD-1) and PD-ligand 1 (PDL1) checkpoint inhibitors and transforming growth factor (TGF) β inhibitors.

Endophytic fungi inhabiting L. plant: diversity, antioxidant, and antibacterial activities of their ethyl acetate extracts.

Objectives: Endophytic fungi are an essential source of biologically active compounds. They have the ability to synthesize secondary metabolites which are the same or have a high degree of similarity to their host plants. In this study, we aimed to explore the biodiversity and the bioactivities of active metabolites produced by 14 endophytic fungi isolated from the medicinal plant L.

Simultaneous nitrification-denitrification (SND) using a thermoplastic gel as support: pollutants removal and microbial community in a pilot-scale biofilm membrane bioreactor.

In this study, experiments were carried out to treat sanitary wastewater in a biofilm membrane bioreactor using a thermoplastic gel as a support to assist the nitrification-denitrification process. For this purpose, the system was operated in two different dissolved oxygen concentrations (2.3 ± 0.

Orange Juice and Yogurt Carrying Probiotic GBI-30 6086: Impact of Intake on Wistar Male Rats Health Parameters and Gut Bacterial Diversity.

This study aimed to investigate the impact of the food matrix (orange juice and yogurt) on the effects of the spore-forming probiotic microorganism GBI-30 6086 in health parameters and gastrointestinal tract (gut) bacterial diversity in male rats. Rats ( = 48) were randomly distributed into six groups. The groups were the Control (which received sterile distilled water), Juice (which received orange juice), Yogurt (which received yogurt), Probiotic (which received GBI-30 6086 in distilled water), Probiotic Juice (which received orange juice with GBI-30 6086), and Probiotic Yogurt (which received yogurt with GBI-30 6086).

Tumor-Associated-Macrophage-Membrane-Coated Nanoparticles for Improved Photodynamic Immunotherapy.

Cell-membrane-coated nanoparticles have emerged as a promising antitumor therapeutic strategy. However, the immunologic mechanism remains elusive, and there are still crucial issues to be addressed including tumor-homing capacity, immune incompatibility, and immunogenicity. Here, we reported a tumor-associated macrophage membrane (TAMM) derived from the primary tumor with unique antigen-homing affinity capacity and immune compatibility.

A synergy interaction of artocarpin and tetracycline against and its mechanism of action on membrane permeability.

The emergence of antibacterial resistance has significantly increased. is associated with nosocomial infection and difficult to control. Artocarpin, a flavonoid from Lam.

Prevention of nosocomial transmission and biofilm formation on novel biocompatible antimicrobial gloves impregnated with biosynthesized silver nanoparticles synthesized using Eucalyptus citriodora leaf extract.

Failure in the prevention of cross-transmission from contaminated gloves has been recognized as an important factor that contributes to the spread of several healthcare-associated infections. Ex situ coating process with silver nanoparticles (AgNPs) using Eucalyptus citriodora ethanolic leaf extract as reducing and capping agents to coat glove surfaces has been developed to prevent this mode of transmission. Elemental analysis of coated gloves showed 24.

Combining Gemcitabine-Loaded Macrophage-like Nanoparticles and Erlotinib for Pancreatic Cancer Therapy.

Pancreatic cancer is a lethal malignancy with a dismal prognosis. Gemcitabine is currently used to treat pancreatic cancer, but it is limited by significant toxicity. Clinical trials on the combination of gemcitabine and erlotinib reported unsatisfactory outcomes along with concerns of toxicity.

Five Tetramic Acid Derivatives Isolated from the Iranian Fungus CCTU A372.

Submerged mycelial cultures of the ascomycete   CCTU A372 were found to produce five previously undescribed tetramic acids, for which we propose the trivial names colposetins A-C (-) and colpomenoic acids A and B ( and ), along with the known compounds penicillide () and monodictyphenone (). The planar structures of - were determined by high-resolution electrospray ionization mass spectrometry (HR-ESIMS) and extensive 1D and 2D nuclear magnetic resonance (NMR) spectroscopy. Their absolute configurations were determined by the combination of electronic circular dischroism (ECD) analysis, -based configurational analysis, and a rotating-frame Overhauser effect spectroscopy (ROESY) experiment.

Optimization of OPEFB lignocellulose transformation process through ionic liquid [TEA][HSO] based pretreatment.

Research on the transformation of Oil Palm Empty Fruit Bunches (OPEFB) through pretreatment process using ionic liquid triethylammonium hydrogen sulphate (IL [TEA][HSO]) was completed. The stages of the transformation process carried out were the synthesis of IL with the one-spot method, optimization of IL composition and pretreatment temperature, and IL recovery. The success of the IL synthesis stage was analyzed by FTIR, H-NMR and TGA.

Effect of biostimulation and bioaugmentation on hydrocarbon degradation and detoxification of diesel-contaminated soil: a microcosm study.

Soil contamination with diesel oil is quite common during processes of transport and storage. Bioremediation is considered a safe, economical, and environmentally friendly approach for contaminated soil treatment. In this context, studies using hydrocarbon bioremediation have focused on total petroleum hydrocarbon (TPH) analysis to assess process effectiveness, while ecotoxicity has been neglected.

Relationship among Agroclimatic Variables, Soil and Leaves Nutrient Status with the Yield and Main Composition of Kaffir Lime ( DC) Leaves Essential Oil.

Previous studies revealed the impact growing location has on the quantity and quality of essential oils derived from numerous spp., except on the kaffir lime. This study aims to analyze the relationship shared by agroclimatic variables and soil-plant nutrient status to kaffir lime leaves essential oil yield and main composition.

Saikosaponin D exhibits anti-leukemic activity by targeting FTO/mA signaling.

The implementation of targeted therapies for acute myeloid leukemia (AML) has been challenging. Fat mass and obesity associated protein (FTO), an mRNA N-methyladenosine (mA) demethylase, functions as an oncogene that promotes leukemic oncogene-mediated cell transformation and leukemogenesis. Here, we investigated the role of Saikosaponin-d (SsD) in broad anti-proliferation effects in AML and evaluated the mA demethylation activity by targeting FTO of SsD.

Examination the Hydrolysis Feasibility of OPEFB Biomass Using Aspergillus niger as Cellulase Enzyme-producing Fungus.

The objective of this study was to obtain optimization results from the biological hydrolysis of Oil Palm Empty Fruit Bunches (OPEFB) using Aspergillus niger (A. niger) BIOTROP 2173 isolated from grain. Optimized hydrolysis parameters include temperature, pH and time.

Ataxia telangiectasia mutated inhibitor-loaded copper sulfide nanoparticles for low-temperature photothermal therapy of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer, and is ranked the sixth most common neoplasm and the third leading cause of cancer-related deaths. Photothermal therapy (PTT) for thermal ablation of local tumors has recently emerged as a therapeutic strategy. However, the relatively high temperature of over 50 °C may lead to unexpected heat-related damage to tumor-adjacent normal tissues.

Amycolatomycins A and B, Cyclic Hexapeptides Isolated from an sp. 195334CR.

The rare actinobacterium sp. strain 195334CR was found to produce previously undescribed cyclic hexapeptides, which we named amycolatomycin A and B ( and ). Their planar structures were determined by high-resolution mass spectrometry as well as extensive 1D and 2D NMR spectroscopy, while the absolute stereochemistry of its amino acids were determined by Marfey's method.

Dietary polyphenols suppress chronic inflammation by modulation of multiple inflammation-associated cell signaling pathways.

The high failure rate of the reductionist approach to discover effective and safe drugs to treat chronic inflammatory diseases has led scientists to seek alternative ways. Recently, targeting cell signaling pathways has been utilized as an innovative approach to discover drug leads from natural products. Cell signaling mechanisms have been identified playing key role in diverse diseases by inducing proliferation, cell survival and apoptosis.

Microplastic contamination in the Skipjack Tuna (Euthynnus affinis) collected from Southern Coast of Java, Indonesia.

Indonesia is the second-largest contributor of microplastics (MPs) pollution in the marine ecosystem. Most MPs pollution-related studies in Indonesia focus on seawater, sediment, with less information found on the commercially important fish species used for human consumption. Skipjack Tuna (Euthynnus affinis) is one of the major exporting fishery commodities from Indonesia.