Increased mortality risk in people with schizophrenia in Lithuania 2001-2020.

The aim of this study was to assess mortality risk in people with schizophrenia in Lithuania from 2001 and 2020. Cause-specific and all-cause mortality risk among patients with schizophrenia was assessed using a retrospective cohort study design. The cohort identified all patients with schizophrenia diagnosis (ICD-10 code F20) who were admitted to the Vilnius Republican Psychiatric Hospital from 1 January, 2001 to December 31, 2020.

Cancer mortality and morbidity among patients with schizophrenia: A hospital-based cohort study, 1992-2020.

Objective: Due to the inconsistency of the evidence about the cancer risk among patients with schizophrenia, the aim of this study was to analyse cancer mortality and morbidity in patients with schizophrenia treated in a single centre in Lithuania during the study period of 1992-2020.

Materials And Methods: A retrospective cohort study was conducted in Vilnius Republican Psychiatric Hospital, the biggest specialised psychiatric hospital in Lithuania, with approximately 5000 hospital admissions annually. The patients' cohort was established by identifying all patients with the diagnosis of schizophrenia (ICD-10 code F20) in the hospital database from 1 January 1992 until 31 December 2017.

Anti-neuroinflammatory microRNA-146a-5p as a potential biomarker for neuronavigation-guided rTMS therapy success in medication resistant depression disorder.

Treatment-resistant depression (TRD) is a challenging issue to address. Repetitive transcranial magnetic stimulation (rTMS) is commonly used but shows varying efficacy, necessitating a deeper understanding of depression physiology and rTMS mechanisms. Notably, an increasing amount of recent data has displayed the connection of TRD and its clinical outcome with chronic inflammatory processes.

Brain stimulation effects on serum BDNF, VEGF, and TNFα in treatment-resistant psychiatric disorders.

Resistance to pharmacological treatment poses a notable challenge for psychiatry. Such cases are usually treated with brain stimulation techniques, including repetitive transcranial magnetic stimulation (rTMS) and electroconvulsive therapy (ECT). Empirical evidence links treatment resistance to insufficient brain plasticity and chronic inflammation.

The use of MR‑less MNI based neuronavigation for 10 Hz rTMS depression therapy: electrophysiological and clinical implications.

Repetitive transcranial magnetic stimulation (rTMS) is a popular and effective treatment for drug resistant depression. However, there is considerable variability in clinical outcomes, in previous studies and between patients. Because of high requirements for the use of fMRI based neuronavigation, many practitioners of rTMS still choose to use a standard 5 cm rule for rTMS coil placement which leads to large variations in which brain regions are being stimulated.

Pathological Imitative Behavior and Response Preparation in Schizophrenia.

Introduction: Pathological imitative behavior (ehopraxia) is occasionally observed in schizophrenia patients. However, only a severe form of echopraxia can be detected with the help of a direct observation. Therefore, our goal was to study a latent form of pathological imitative behavior in this disorder, which is indicated by an increase of imitative tendencies.

Early- and late-latency gamma auditory steady-state response in schizophrenia during closed eyes: Does hallucination status matter?

Objectives: Auditory steady-state responses are larger in patients experiencing auditory verbal hallucinations (AVH) than in never hallucinating subjects (NH) when recorded with open eyes. Compensatory effects were shown for schizophrenic patients when recorded with closed eyes. This effect has not been evaluated in respect to hallucination status.

Response preparation and intra-individual reaction time variability in schizophrenia.

It is important to prepare response in advance to increase the efficiency of its execution. The process of response preparation is usually studied using the precueing paradigm. In this paradigm subjects have to employ the preceding information about further imperative stimulus to perform proper response preparation, which shortens the reaction time of subsequent response execution.

Intra-individual reaction time variability and response preparation: an EEG study.

To behave more efficiently the human brain must anticipate future events with different probabilities and prepare appropriate responses. Previous studies demonstrated that participants react faster to more probable stimuli. It has been shown that this effect in reaction time reduction is related to the response preparation process.

Parameters of the spectral analysis of the heart rate variability in treating depression.

Unlabelled: The objective of this work was to study circadian rhythms of the indicators of the spectral analysis of the heart rate variability in case of depression.

Materials And Methods: A total of 37 patients, with a mean age of 46.7+/-10.

Effects of risperidone on auditory information processing in neuroleptic-naive patients with schizophrenia spectrum disorders.

Early effects of risperidone (2.5 +/- 1 mg/day) on auditory information processing were investigated in 9 neuroleptic naive patients with schizophrenia spectrum disorders and 9 healthy controls by using event-related potentials (ERPs). ERPs were elicited during active auditory "oddball" paradigm and were recorded before and after two weeks of treatment.

Effects of olanzapine on auditory P300 and mismatch negativity (MMN) in schizophrenia spectrum disorders.

We investigated effects of olanzapine (5-10 mg/day) on passive and active attention in 11 patients with schizophrenia spectrum disorders and 15 healthy controls by using auditory evoked potentials (AEPs) mismatch negativity (MMN) and P300. AEPs were elicited during active and passive auditory "oddball" paradigms before, after 2 weeks and 4 weeks of olanzapine treatment. Baseline P300 amplitudes, but not MMN, were significantly reduced in patients compared with controls.

Evaluation of new MMN parameters in schizophrenia.

ERPs could be helpful in the objectification of many psychological measures. In the last few decades one of the most commonly used ERPs has been the mismatch negativity (MMN) potential. It may be used to detect cognitive dysfunction in patients suffering from schizophrenia, dementia, depression, and can also be successfully applied in treatment monitoring.