TMP: A dual modulator of apoptosis and autophagy via SHP-1 regulation in hepatocellular carcinoma.

Background: Hepatocellular carcinoma (HCC) poses a significant health burden due to its high incidence, and current treatment effectiveness is hindered by drug resistance. Thus, investigation of novel therapeutic approaches derived from natural sources is crucial for improving patient outcomes.

Aims: This study aimed to explore the potential of Tetramethylpyrazine (TMP), bioactive alkaloid (ligustrazine) isolated from Chuanxiong (Ligusticum Wallichii), in targeting HCC by inducing apoptosis and enhancing autophagy.

Exploring the impact of force direction and phase on bone conduction hearing with bone conduction actuator.

A comprehensive understanding of the effects of bone conduction (BC) input force is essential for elucidating BC hearing mechanisms. However, this area remains underexplored due to the inherent difficulties in controlling input forces when BC transducers are anchored to the bone. In this study, the effects of both unilateral and bilateral BC input forces were investigated using a three-dimensional finite element (FE) model of the human head, which allows precise manipulation of input forces.

Current status and future directions of explainable artificial intelligence in medical imaging.

The inherent "black box" nature of AI algorithms presents a substantial barrier to the widespread adoption of the technology in clinical settings, leading to a lack of trust among users. This review begins by examining the foundational stages involved in the interpretation of medical images by radiologists and clinicians, encompassing both type 1 (fast thinking - ability of the brain to think and act intuitively) and type 2 (slow analytical - slow analytical, laborious approach to decision-making) decision-making processes. The discussion then delves into current Explainable AI (XAI) approaches, exploring both inherent and post-hoc explainability for medical imaging applications and highlighting the milestones achieved.

Sintering Evolving MnO-LaMnO Perovskite Heterointerfaces as Highly Active and Durable Catalysts for Catalytic Removal of Volatile Organic Compounds.

Improving the catalyst performance for the thermal oxidation reaction faces the daunting challenge of the activity-stability trade-off. Herein, an evolved heterointerface was constructed on spherical MnO nanocatalysts to achieve exceptional stability while maintaining adequate activity by simply introducing La. The generation of the active MnO-MnO heterointerfaces by La doping was experimentally observed, which further segregates to the surface during thermal aging and forms epitaxially grown heterostructured LaMnO-MnO with Mn atoms.

Water sorption performance of the zeolitic metal azolate framework MAF-7.

Water sorption isotherms of [Zn(mtz)] (MAF-7) were collected over a wide temperature range (15-45 °C) and its water sorption performance was assessed in terms of water uptake, sorption kinetics, recyclability, and regeneration temperature. Additionally, molecular simulations were conducted to elucidate the locations of water molecules within the pore cavity of MAF-7.

2D Conjugated Metal-Organic Frameworks for New Generation Flexible Multicolor Electrochromic Devices.

There has been considerable interest in 2D conductive conjugated MOFs (2D c-MOFs) for their potential applications in sensors, opto-electronics, catalysis, and energy storage, owing to their ultra-high specific surface area, relatively high electrical conductivity, and tunable pore channel sizes for ion/charge diffusion/adsorption. The unique advantages brought by systematic tunings in the metal nodes and organic ligands enable the creation of highly accessible and remarkable structures with diverse chemical and physical behaviors. While the 2D c-MOFs are being explored for the rapid widening spectrum of applications, in this work, the great potential of multicolor transitions and functional properties of these 2D c-MOFs are examined for the new generation of flexible multicolor electrochromic devices (FMEDs).

Machine Learning-based Prognostic Subgrouping of Glioblastoma: A Multi-center Study.

Background: Glioblastoma is the most aggressive adult primary brain cancer, characterized by significant heterogeneity, posing challenges for patient management, treatment planning, and clinical trial stratification.

Methods: We developed a highly reproducible, personalized prognostication and clinical subgrouping system using machine learning (ML) on routine clinical data, MRI, and molecular measures from 2,838 demographically diverse patients across 22 institutions and 3 continents. Patients were stratified into favorable, intermediate, and poor prognostic subgroups (I, II, III) using Kaplan-Meier analysis (Cox proportional model and hazard ratios [HR]).

Impact of grain boundaries on the electronic properties and Schottky barrier height in MoS@Au heterojunctions.

Using density functional theory (DFT) calculations we thoroughly explored the influence of grain boundaries (GBs) in monolayer MoS composed of S-polar (S5|7), Mo-polar (Mo5|7), and (4|8) edge dislocation, as well as an edge dislocation-double S vacancy complex (S4|6), and a dislocation-double S interstitial complex (S6|8), respectively, on the electronic properties of MoS and the Schottky barrier height (SBH) in MoS@Au heterojunctions. Our findings demonstrate that GBs formed by edge dislocations can significantly reduce the SBH in defect-free MoS, with the strongest effect for zigzag (4|8) GBs (-20% reduction) and the weakest for armchair (5|7) GBs (-10% reduction). In addition, a larger tilt angle in the GBs leads to a more pronounced decrease in the SBH, suggesting that the modulation of SBH in the MoS@Au heterostructure and analogous systems can be accomplished by GB engineering.

π-HuB: the proteomic navigator of the human body.

The human body contains trillions of cells, classified into specific cell types, with diverse morphologies and functions. In addition, cells of the same type can assume different states within an individual's body during their lifetime. Understanding the complexities of the proteome in the context of a human organism and its many potential states is a necessary requirement to understanding human biology, but these complexities can neither be predicted from the genome, nor have they been systematically measurable with available technologies.

Long-acting injectable antipsychotic use in patients with bipolar disorder: Findings from the REAP-BD study.

Aims: This study aimed to assess treatment patterns and the effectiveness of long-acting injectable antipsychotics (LAIs) in patients with bipolar disorder (BD) across various Asian countries. The study focused on comparing the choices of LAIs, other psychotropic medications, and their psychotropic drug load to explore real-world usage and evaluate the potential benefits of LAIs in BD treatment across different countries.

Methods: A retrospective cohort study was conducted with BD patients diagnosed according to ICD-10-CM codes F31.

Constructing High-Performance Yarn-Shaped Electrodes via Twisting-after-Coating Technique for Weavable Seawater Battery.

Seawater batteries (SWBs) are green aqueous power sources with great potential in marine applications. So far, SWBs are mainly built on rigid substrates, which hinders their adaptability to marine textile applications. Herein, we constructed a rechargeable yarn-shaped SWB consisting of nickel hexacyanoferrate (Ni-HCF)-modified carbon yarn (positive electrode), glass fiber diaphragm, and polyimide (PI)-modified carbon yarn (negative electrode).

Protocol for feeding strategy and proteomics analysis of zebrafish Danio rerio using S-trap and iTRAQ techniques.

Yeast serves as a functional alternative and sustainable protein source in aquaculture. This protocol outlines feeding strategy and intestinal proteome analysis of zebrafish (Danio rerio), using S-trap for digestion, iTRAQ, and mass spectrometry for protein quantification. Additionally, it details the analysis of chemical components in feed and functional assessments via Kyoto Encyclopedia of Genes and Genomes (KEGG), Eukaryotic Orthologous Group (KOG), and Gene Ontology (GO).

BEEx Is an Open-Source Tool That Evaluates Batch Effects in Medical Images to Enable Multicenter Studies.

The batch effect is a nonbiological variation that arises from technical differences across different batches of data during the data generation process for acquisition-related reasons, such as collection of images at different sites or using different scanners. This phenomenon can affect the robustness and generalizability of computational pathology- or radiology-based cancer diagnostic models, especially in multicenter studies. To address this issue, we developed an open-source platform, Batch Effect Explorer (BEEx), that is designed to qualitatively and quantitatively determine whether batch effects exist among medical image datasets from different sites.

Revolutionizing cancer treatment: the emerging potential and potential challenges of self-processed CAR cell therapy.

Chimeric antigen receptor (CAR) cell immunotherapies, including CAR-T, CAR-Macrophages, CAR-Natural Killer, CAR-γδ T, etc., have demonstrated significant advancements in the treatment of both hematologic malignancies and solid tumors. Despite the notable successes of traditional CAR cell manufacturing, its application remains constrained by the complicated production process and expensive costs.

Meta-structure of amorphous-inspired 65.1Co28.2Cr5.3Mo lattices augmented by artificial intelligence.

Unlabelled: A hatching-distance-controlled lattice of 65.1Co28.2Cr5.

Integrative Taxonomy Reveals Freshwater Shrimp Diversity (Decapoda: Atyidae: ) from Kyushu and Southern Honshu of Japan, with a Discussion on Introduced Species.

Correct identification of species is crucial for invasion ecology and management, particularly in aquatic systems. In this study, specimens of the freshwater shrimp genus from Kyushu and southern Honshuof Japan were identified by using an integrative approach that combined DNA barcoding of mitochondrial cytochrome oxidase subunit I () and morphological examination. Among the eight species detected, two are native, viz.

1D Flat Bands in Phosphorene Nanoribbons with Pentagonal Nature.

Materials with flat bands can serve as a promising platform to investigate strongly interacting phenomena. However, experimental realization of ideal flat bands is mostly limited to artificial lattices or moiré systems. Here, a general way is reported to construct 1D flat bands in phosphorene nanoribbons (PNRs) with a pentagonal nature: penta-hexa-PNRs and penta-dodeca-PNRs, wherein the corresponding 1D flat bands are directly verified by using angle-resolved photoemission spectroscopy.

A Quantitative Study of the Halogenophilic Nucleophilic Substitution (S2X) Reaction and Chalcogenophilic Nucleophilic Substitution (S2Ch) Reaction.

Halogenophilic nucleophilic substitution (S2X) has a distinctly different reaction pathway compared to the bimolecular nucleophilic substitution reaction (S2), but they can lead to the same reaction product. However, their differences can be distinguished by studying stereoselective reactions in which both reaction pathways are possible. Herein, we utilize the stereospecific nature of S2 and the presence of a pro-chiral anion intermediate in S2X to conduct a quantitative study in which both S2 and S2X reactions exist.

Impact of the COVID-19 outbreak on the field of hematopoietic cell transplantation in the Asia-Pacific region: APBMT Activity Survey 2020/2021.

COVID-19 became a global pandemic in 2020 and significantly affected the activity of hematopoietic cell transplants (HCT) worldwide. Despite these challenges, a total of 28,793 transplants, including 18,518 allogeneic and 10,275 autologous transplants, were performed in 719 facilities in 2020 in the Asia-Pacific (AP) region. This represented a 5.

Taxonomy and bioacoustics of some crickets (Orthoptera: Grylloidea) from Panti Forest Reserve (Peninsular Malaysia: Johor).

Orthopteran surveys were recently conducted at the Panti Forest Reserve in Johor State of Peninsular Malaysia. Based on new material, three species new to science are described here: Agryllus sori Tan, Muhammad & Gorochov, sp. nov.

Pseudolitochira spinosa, a new species of pilumnid crab from Panglao, Philippines, with a note on P. setosa (A. Milne-Edwards, 1873) (Crustacea, Brachyura, Pilumnoidea).

A new species of pilumnid crab, Pseudolitochira spinosa sp. nov., is described from a seagrass bed in Panglao, Bohol, central Philippines.

Checklist of the Odonata (Insecta) of Sundaland and Wallacea (Malaysia, Singapore, Brunei, Indonesia and Timor Leste).

A checklist, based on a database containing published data, of the Odonata (dragonflies and damselflies) occurring in Sundaland and Wallacea is presented. The presence of (sub)species is indicated for eight main regions (Singapore & Peninsular Malaysia, South China Sea (islands in the South China Sea that are not sensibly treated as satellites of larger landmasses), Borneo, Sumatra, Java & Bali, Lesser Sunda, Sulawesi, Moluccas), 22 subregions and 80 smaller islands and island groups. In total 743 full species are recorded from the entire area with 549 species known from Sundaland and 270 from Wallacea.

A new genus and a new species of Cladonotinae (Orthoptera: Tetrigidae) from Mindanao, Philippines.

A new genus and a new species of Cladonotinae (Orthoptera: Tetrigidae) is described from Mount Malindang in Mindanao, Philippines: Fartmanntettix undulatus Tan & Tumbrinck, gen. et sp. nov.

New species of little-known crickets from the subfamily Pteroplistinae (Orthoptera, Grylloidea) from Sabah and contribution to their bioacoustics.

Recent fieldwork in eastern Sabah led to the discovery of new little-known crickets from the subfamily Pteroplistinae (Orthoptera, Grylloidea). Three new species are described: Tembelingiola biaculeata sp. nov.