268,033 results match your criteria: "Republic of Korea; Seoul St. Mary's Hospital H-Y.P.[Affiliation]"

Background: Human placental hydrolysate (hPH) contains anti-inflammatory substances. This study aimed to analyze whether injecting hPH into the subacromial space could reduce pain in patients with shoulder impingement syndrome.

Methods: This single-blind, randomized controlled study enrolled 50 patients with shoulder impingement syndrome who were randomly assigned to either the hPH or placebo groups.

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Metabolic engineering of Priestia megaterium for 2'-fucosyllactose production.

Microb Cell Fact

January 2025

Department of Chemical & Biological Engineering, Korea University, Seoul, 136-763, Korea.

Background: 2'-Fucosyllactose (2'-FL) is a predominant human milk oligosaccharide that significantly enhances infant nutrition and immune health. This study addresses the need for a safe and economical production of 2'-FL by employing Generally Recognized As Safe (GRAS) microbial strain, Priestia megaterium ATCC 14581. This strain was chosen for its robust growth and established safety profile and attributing suitable for industrial-scale production.

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Crisdesalazine alleviates inflammation in an experimental autoimmune encephalomyelitis multiple sclerosis mouse model by regulating the immune system.

BMC Neurosci

January 2025

Laboratory of Veterinary Internal Medicine, Department of Clinical Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, 08826, Republic of Korea.

Microglia/macrophages participate in the development of and recovery from experimental autoimmune encephalomyelitis (EAE), and the macrophage M1 (pro-inflammatory)/M2 (anti-inflammatory) phase transition is involved in EAE disease progression. We evaluated the efficacy of crisdesalazine (a novel microsomal prostaglandin E2 synthase-1 inhibitor) in an EAE model, including its immune-regulating potency in lipopolysaccharide-stimulated macrophages, and its neuroprotective effects in a macrophage-neuronal co-culture system. Crisdesalazine significantly alleviated clinical symptoms, inhibited inflammatory cell infiltration and demyelination in the spinal cord, and altered the phase of microglial/macrophage and regulatory T cells.

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Novel transfer learning based bone fracture detection using radiographic images.

BMC Med Imaging

January 2025

Department of Information and Communication Engineering, Yeungnam University, Gyeongsan, 38541, Republic of Korea.

A bone fracture is a medical condition characterized by a partial or complete break in the continuity of the bone. Fractures are primarily caused by injuries and accidents, affecting millions of people worldwide. The healing process for a fracture can take anywhere from one month to one year, leading to significant economic and psychological challenges for patients.

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Background: Adenosine deaminase action on RNA 1 (ADAR1) can convert the adenosine in double-stranded RNA (dsRNA) molecules into inosine in a process known as A-to-I RNA editing. ADAR1 regulates gene expression output by interacting with RNA and other proteins; plays important roles in development, including growth; and is linked to innate immunity, tumors, and central nervous system (CNS) diseases.

Results: In recent years, the role of ADAR1 in tumors has been widely discussed, but its role in CNS diseases has not been reviewed.

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Background: Although bariatric surgery is the most effective obesity treatment, few nationwide cohort studies have evaluated its safety. This study aimed to evaluate surgical trends after insurance coverage implementation and analyze the surgical outcomes of bariatric surgery.

Methods: A retrospective analysis of bariatric surgery in patients with obesity was conducted using data from Korean National Health Insurance System (NHIS) claims.

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Background And Aims: Self-expandable metal stents (SEMS) are effective in alleviating malignant colorectal obstruction. However, bowel perforation following SEMS placement remains a significant concern, as it can adversely affect oncological outcomes. This study aimed to evaluate the recurrence and overall survival rates associated with SEMS-related bowel perforations.

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During nasal polyp (NP) development, activated T cells differentiate into T helper (Th) 1, Th2, and Th17 cells. Additionally, regulatory T cells (Tregs) that have an immune suppressive function are involved in the pathophysiology of chronic rhinosinusitis (CRS) with NP (CRSwNP). Tregs can act as effector cells that produce inflammatory cytokines, such as interleukin (IL)-17A.

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Long-term clinical outcome of a weekly 2-chlorodeoxyadenosine regimen in treatment-naïve patients with hairy cell leukemia.

Ann Hematol

January 2025

Department of Hematology, Seoul St. Mary's Hematology Hospital, College of Medicine, The Catholic University of Korea, Banpo-daero 222, Seocho-Gu, Seoul, South Korea.

Hairy cell leukemia (HCL) has a favorable clinical outcome with appropriate treatment; however, further research is needed on managing patients with relapsed or refractory disease and the risk of infection during prolonged periods. This study examined the long-term effects of 2-chlorodeoxyadenosine (2-CdA), particularly using a weekly infusion protocol, in treatment-naïve patients with HCL. This retrospective study evaluated the long-term follow-up data from 21 South Korean patients diagnosed with HCL.

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With the significant development in photovoltaic (PV) systems, focus has been placed on inexpensive, efficient, and innovative power converter solutions, leading to a high diversity within power converters and new system configurations for grid-connected PV (GCPV) systems. During the last decade, multilevel inverter (MLI) designs have gained popularity in GCPV applications. This article provides a wide-ranging investigation of the common MLI topology in contrast to other existing MLI topologies for PV applications.

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ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip.

Nat Genet

January 2025

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

Transcription factors are frequent cancer driver genes, exhibiting noted specificity based on the precise cell of origin. We demonstrate that ZIC1 exhibits loss-of-function (LOF) somatic events in group 4 (G4) medulloblastoma through recurrent point mutations, subchromosomal deletions and mono-allelic epigenetic repression (60% of G4 medulloblastoma). In contrast, highly similar SHH medulloblastoma exhibits distinct and diametrically opposed gain-of-function mutations and copy number gains (20% of SHH medulloblastoma).

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Thermal sensitivity and niche plasticity of generalist and specialist leaf-endophytic bacteria in Mangrove Kandelia obovata.

Commun Biol

January 2025

Key Laboratory of Climate, Resources and Environment in Continental Shelf Sea and Deep Sea of Department of Education of Guangdong Province, Department of Oceanography, Key Laboratory for Coastal Ocean Variation and Disaster Prediction, College of Ocean and Meteorology, Guangdong Ocean University, Zhanjiang, China.

Leaf endospheres harbor diverse bacterial communities, comprising generalists and specialists, that profoundly affect ecosystem functions. However, the ecological dynamics of generalist and specialist leaf-endophytic bacteria and their responses to climate change remain poorly understood. We investigated the diversity and environmental responses of generalist and specialist bacteria within the leaf endosphere of mangroves across China.

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Detecting brain tumours (BT) early improves treatment possibilities and increases patient survival rates. Magnetic resonance imaging (MRI) scanning offers more comprehensive information, such as better contrast and clarity, than any alternative scanning process. Manually separating BTs from several MRI images gathered in medical practice for cancer analysis is challenging and time-consuming.

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Autism spectrum disorder (ASD) affects up to 1 in 59 children, and is one of the most common neurodevelopmental disorders. Recent genomic studies have highlighted the role of rare variants in ASD. This study aimed to identify genes affected by rare variants shared by siblings with ASD and validate the function of a candidate gene FRRS1L.

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Risk-based bridge life cycle cost and environmental impact assessment considering climate change effects.

Sci Rep

January 2025

Department of Civil and Environmental Engineering, Seoul National University, Seoul, 08826, Republic of Korea.

To enhance sustainability and resilience against climate change in infrastructure, a quantitative evaluation of both environmental impact and cost is important within a life cycle framework. Climate change effects can lead performance deterioration in bridge components during their operational phase, highlighting the necessity for a risk-based evaluation process aligned with maintenance strategies. This study employs a two-phase life cycle assessments (LCA) framework.

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Design, synthesis, in vitro, and in silico studies of 4-fluorocinnamaldehyde based thiosemicarbazones as urease inhibitors.

Sci Rep

January 2025

Department of Chemical and Biological Engineering, College of Engineering, Korea University, Seoul, 02841, Republic of Korea.

Clinically significant problems such as kidney stones and stomach ulcers are linked to the activation of the urease enzyme. At low pH, this enzyme gives an ideal environment to Helicobacter pylori in the stomach which is the cause of gastric ulcers and peptic ulcers. In recent work, we have developed a library of 4-fluorocinnamaldehyde base thiosemicarbazones and assessed them for their potential against urease enzyme.

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Despite its profound significance, the molecular structural changes near the transition state, driven by the vibronic coupling, have remained largely unexplored, leaving a crucial aspect of chemical reactions shrouded in uncertainty. Herein, the dynamical behavior of the reactive flux on the verge of chemical bond breakage was revealed through the spectroscopic characterization of a large amplitude vibrational motion. Highly excited internal rotor states of S methylamine (CHND) report on the structural change as the molecule approaches the transition state, indicating that the quasi-free internal rotation is strongly coupled to the reaction coordinate as their energies near the maximum of the reaction barrier for the N-D chemical bond predissociation.

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Conventional chemotherapy- and radiotherapy-induced cancer senescence, which is characterized by poor proliferation, drug resistance, and senescence-associated secretory phenotype, has gained attention as contributing to cancer relapse and the development of an immunosuppressive tumor microenvironment. However, the association between cancer senescence and anti-tumor immunity is not fully understood. Here, we demonstrate that senescent cancer cells increase the level of PD-L1 by promoting its transcription and glycosylation.

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An updated review about the possibility of surveillance strategy in non-resected mucinous cystic neoplasms.

J Hepatobiliary Pancreat Sci

January 2025

Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.

After the World Health Organization established a precise definition of mucinous cystic neoplasm (MCN) in 2000, based on the presence of ovarian-type stroma, its clinical features became more apparent. Surgery for MCN, which primarily affects middle-aged women with long life expectancies, is likely to negatively impact the patient's quality of life. Although recent studies have reported a low proportion of advanced neoplasia among resected MCN (≤15%), many clinicians still recommend surgery for patients with presumed MCN without considering risk stratification for advanced neoplasia.

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Introduction: The unique natural and social environments of East Asia may shape the characteristics of fungal skin diseases. However, there is a notable absence of thorough comparative analyses on this subject.

Methods: This research undertook a comprehensive analysis of the epidemiology and disease burden of fungal dermatoses across five East Asian countries (China, Japan, Republic of Korea, Democratic People's Republic of Korea and Mongolia) via the Global Burden of Disease (GBD) database from 1990 to 2021.

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Recent progress in biopolymer-based electrospun nanofibers and their potential biomedical applications: A review.

Int J Biol Macromol

January 2025

School of Chemical Engineering, Yeungnam University, 280-Daehak-ro, Gyeongsan 38541, Republic of Korea. Electronic address:

Tissue engineering offers an alternative approach to developing biological substitutes that restore, maintain, or enhance tissue functionality by integrating principles from medicine, biology, and engineering. In this context, biopolymer-based electrospun nanofibers have emerged as attractive platforms due to their superior physicochemical properties, including excellent biocompatibility, non-toxicity, and desirable biodegradability, compared to synthetic polymers. Considerable efforts have been dedicated to developing suitable substitutes for various biomedical applications, with electrospinning receiving considerable attention as a versatile technique for fabricating nanofibrous platforms.

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Cardiorespiratory signals have long been treated as "noise" in functional magnetic resonance imaging (fMRI) research, with the goal of minimizing their impact to isolate neural activity. However, there is a growing recognition that these signals, once seen as confounding variables, provide valuable insights into brain function and overall health. This shift reflects the dynamic interaction between the cardiovascular, respiratory, and neural systems, which together support brain activity.

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Purpose The purpose of this study was to evaluate whether IV dexamethasone, within the current multimodal pain management protocol, (1) could maintain postoperative pain at a comparable level without IV PCA, (2) could reduce opioids-related side effects, and (3) whether an additional dose of dexamethasone on POD 2 would offer further pain-relieving effect without increasing the risk of complications. Methods A total of 178 patients (182 knees) who underwent total knee arthroplasty (TKA) for osteoarthritis were included in the study. The patients were divided into Dexa 2 & PCA and Dexa 3 & NoPCA group.

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