Urinary DNA Methylation Test for Bladder Cancer Diagnosis.

Importance: An accurate noninvasive biomarker test is needed for the early diagnosis of bladder cancer.

Objective: To evaluate the performance of a urinary DNA methylation test (PENK methylation) and compare its diagnostic accuracy with that of the nuclear matrix protein 22 (NMP22) test or urine cytology test.

Design, Setting, And Participants: In this prospective multicenter study at 10 sites in the Republic of Korea, individuals 40 years and older with hematuria undergoing cystoscopy within 3 months between March 11, 2022, and May 30, 2024, participated.

Adjuvant Atezolizumab for Early Triple-Negative Breast Cancer: The ALEXANDRA/IMpassion030 Randomized Clinical Trial.

Importance: Triple-negative breast cancer is an aggressive subtype with a high incidence in young patients, a high incidence in non-Hispanic Black women, and a high risk of progression to metastatic cancer, a devastating sequela with a 12- to 18-month life expectancy. Until recently, one strategy for treating early-stage triple-negative breast cancer was chemotherapy after surgery. However, it was not known whether the addition of immune therapy to postsurgery chemotherapy would be beneficial.

Low-Temperature Chemical Solution Deposition of BiOSe on Amorphous Surface for Dynamic Memristor of Physical Reservoir Array.

Bismuth oxyselenide (BiOSe) stands as a highly promising layered semiconductor with outstanding optical, electrical, and thermal properties. For the practical application of the material toward the devices, growing BiOSe directly on the amorphous substrate at low temperatures (<400 °C) is essential; however, the negatively charged bottom Se layer originating from alternating stacks of Se and [BiO] has hindered this process. In this work, we report the method for synthesizing a BiOSe film on amorphous alumina (AlO) directly at 350 °C by using chemical solution deposition.

Enhanced high-energy proton radiation hardness of ZnO thin-film transistors with a passivation layer.

Metal-oxide thin-film semiconductors have been highlighted as next-generation space semiconductors owing to their excellent radiation hardness based on their dimensional advantages of very low thickness and insensitivity to crystal structure. However, thin-film transistors (TFTs) do not exhibit intrinsic radiation hardness owing to the chemical reactions at the interface exposed to ambient air. In this study, significantly enhanced radiation hardness of AlO-passivated ZnO TFTs against high-energy protons with energies of up to 100 MeV is obtained owing to the passivation layer blocking interactions with external reactants, thereby maintaining the chemical stability of the thin-film semiconductor.

Microscopic Heterogeneity Driven by Molecular Aggregation and Water Dynamics in Aqueous Osmolyte Solutions.

Water dynamics are investigated in binary osmolyte-water mixtures, exhibiting a microscopic heterogeneity driven by molecular aggregation, on the basis of molecular dynamics (MD) simulation studies. The protecting osmolyte TMAO molecules in solution are evenly dispersed without the formation of noticeable osmolyte aggregates, while the denaturant TMU molecules aggregate readily, generating microscopic heterogeneity in the spatial distribution of component molecules in TMU-water mixtures. A combined study of MD simulation with graph theoretical analysis and spatial inhomogeneity measurement with -values in the two osmolyte solutions revealed that the translational and rotational motions of water in the microheterogeneous environment of TMU-water mixtures are less hindered than those in the homogeneous media of TMAO-water mixtures.

Distinct Aggregation Behavior of -Terminally Truncated Aβ Over Aβ in the Presence of Zn(II).

The deposition of amyloid-β (Aβ) aggregates and metal ions within senile plaques is a hallmark of Alzheimer's disease (AD). Among the modifications observed in Aβ peptides, -terminal truncation at Phe4, yielding Aβ, is highly prevalent in AD-affected brains and significantly alters Aβ's metal-binding and aggregation profiles. Despite the abundance of Zn(II) in senile plaques, its impact on the aggregation and toxicity of Aβ remains unexplored.

Validation of a Pretransplant Risk Prediction Model for Early Allograft Dysfunction After Living-donor Liver Transplantation.

Background: Early allograft dysfunction (EAD) affects outcomes in liver transplantation (LT). Existing risk models developed for deceased-donor LT depend on posttransplant factors and fall short in living-donor LT (LDLT), where pretransplant evaluations are crucial for preventing EAD and justifying the donor's risks.

Methods: This retrospective study analyzed data from 2944 adult patients who underwent LDLT at 17 centers between 2016 and 2020.

Delayed Superficial Temporal Artery Pseudoaneurysm Following Minor Trauma in a Post-facelift Patient.

A 37-year-old woman with a history of facelift surgery presented with a painless temporal mass after surfboard trauma. Physical examination revealed a 1 cm pulsatile mass, and ultrasound confirmed a superficial temporal artery pseudoaneurysm. Surgical excision was complicated by adhesions from previous facial surgery and steroid injections.

Detection of chronic wasting disease prions in the farm soil of the Republic of Korea.

Chronic wasting disease (CWD) is a highly contagious prion disease occurring in free-ranging and farmed cervids. CWD continues to spread uncontrolled across North America, and cases continue to be detected almost every year in the Republic of Korea. CWD-infected animals contaminate the soil by releasing infectious prions through their excreta, and shed prions accumulate and remain infectious in the soil for years.

Selective Synthesis of Acyl-Sulfonyl Hydrazide Isomers: The Role of the Countercation of Base Selection in Palladium-Catalyzed Aminocarbonylations.

Selective synthesis of isomeric -acyl--sulfonyl and ,-acyl-sulfonyl hydrazides is achieved via palladium-catalyzed aminocarbonylation of aryl iodides with sulfonyl hydrazides under CO. The base's countercation, rather than its basicity, controls product isomerism. Conventional bases yield linear isomers, whereas sodium-based bases favor branched ones.

Copper(II) complexes of 2-hydroxy-1-naphthaldehyde Schiff bases: synthesis, activity and computational studies.

Background: Due to the divers biological applications of Cu(II) complexes, we in this study reports the various Cu(II) complexes. The study aims to synthesize and assess new Cu(II) complexes as powerful β-glucuronidase inhibitors.

Methods: Five Schiff base ligands and their complexes were synthesized, characterized, and screened against β-glucuronidase inhibitory activity.

Development of digital therapeutics in Hwa-byung treatment: exploring innovation potential in Korean medicine through practitioner survey.

Introduction: Hwa-byung (HB) is a culture-bound anger syndrome prevalent in Korea. While clinical practice guidelines emphasize mind-body modalities (MBMs) and psychotherapies for HB treatment, their implementation in Korean medicine (KM) remains unexplored. Digital therapeutics (DTx) offers potential solutions for treatment delivery barriers.

A scoping review and expert consensus on digital determinants of health.

Objective: To map how social, commercial, political and digital determinants of health have changed or emerged during the recent digital transformation of society and to identify priority areas for policy action.

Methods: We systematically searched MEDLINE, Embase and Web of Science on 24 September 2023, to identify eligible reviews published in 2018 and later. To ensure we included the most recent literature, we supplemented our review with non-systematic searches in PubMed® and Google Scholar, along with records identified by subject matter experts.

Nuclear factor I-C regulates intramembranous bone formation via control of FGF signalling.

Our previous studies indicate that NFI-C is essential for tooth root development and endochondral ossification. However, its exact role in calvarial intramembranous bone formation remains unclear. In this study, we demonstrate that the disruption of the gene leads to defects in intramembranous bone formation, characterized by decreased osteogenic proliferative activity and reduced osteoblast differentiation during postnatal osteogenesis.

Anti-melanogenic effects of hydroxyethyl chrysin through the inhibition of tyrosinase activity: and approaches.

The suppression of tyrosinase (TYR), a key enzyme in melanogenesis, has been suggested as an effective strategy for preventing melanin accumulation. We previously discovered the novel chrysin derivative hydroxyethyl chrysin (HE-chrysin) through an irradiation technique, which exerted higher anti-inflammatory and anti-cancer activities than original chrysin. In the present study, we explored whether HE-chrysin has antioxidant and anti-melanogenic capacity using B16F10 murine melanoma cells and molecular docking.

Recent 5‑year trends in biliary tract cancer survival rates: An analytical big data survey.

Biliary tract cancer (BTC), also known as cholangiocarcinoma, is a relatively rare type of cancer with a poor prognosis. Despite the combination of chemotherapy and advances in targeted therapy, which have potentially improved the prognosis of patients with BTC, research on outcomes remains inadequate. The present study thus analyzed the survival trends of patients with BTC.

A systematic review of cognitive telerehabilitation in patients with cognitive dysfunction.

Introduction: One of the possible treatment options for patient with cognitive dysfunction is cognitive telerehabilitation. Previous systematic reviews on cognitive telerehabilitation have focused on specific disease groups and the analysis of intervention methods did not differentiate between traditional face-to-face cognition treatment and usual care. In this systematic review, we aim to analyze randomized controlled trials (RCTs) that compare telerehabilitation with face-to-face treatment or usual care for improving cognitive function in elderly individuals with cognitive dysfunction or patients with acquired brain injury.

Nutrition users' guides: RCTs part 1 - structured guide for assessing risk of bias in randomised controlled trials that address therapy or prevention questions.

The purpose of this article, part 1 of 2 on randomised controlled trials (RCTs), is to provide readers (eg, clinicians, patients, health service and policy decision-makers) of the nutrition literature structured guidance on interpreting RCTs. Evaluation of a given RCT involves several considerations, including the potential for risk of bias, the assessment of estimates of effect and their corresponding precision, and the applicability of the evidence to one's patient. Risk of bias refers to flaws in the design or conduct of a study that may lead to a deviation from measuring the underlying true effect of an intervention.

Synergistic effects of and zinc oxide in polyvinyl alcohol films for enhanced UV and blue light shielding, antimicrobial properties, and hydrophobicity: improving application performance in sustainable packaging and protective eyewear.

This study investigates the development and characterization of a novel composite material consisting of polyvinyl alcohol (PVA) integrated with (UG) and zinc oxide (ZnO) as fillers. The synergistic effects of UG and ZnO were investigated, focusing on their ability to enhance the film's properties. UV-vis spectrophotometry demonstrated that the composite film effectively blocked all UV (UV-A and UV-B) and blue light wavelengths.

Effect of polishing on the morphology of Zircaloy-4 nanostructure: formation of a novel hexagonal nanoscale pattern.

Zircaloy-4 (Zr-4) is widely used as the cladding material in nuclear power plants (NPPs) due to its excellent corrosion resistance and low neutron absorption cross-section. Under Loss of Coolant Accident (LOCA) conditions, oxidation of Zr-4 can compromise the safety of the NPPs by accelerating hydrogen production. Therefore, enhancing the oxidation resistance of Zr-4 is a critical research focus.

Correction to: Recent Update on PET/CT Radiotracers for Imaging Cerebral Glioma.

[This corrects the article DOI: 10.1007/s13139-024-00847-4.].

Correction to: Imaging Procedure and Clinical Studies of [F]FP‑CIT PET.

[This corrects the article DOI: 10.1007/s13139-024-00840-x.].