Hair Regeneration Methods Using Cells Derived from Human Hair Follicles and Challenges to Overcome.

The hair follicle is a complex of mesenchymal and epithelial cells acquiring different properties and characteristics responsible for fulfilling its inductive and regenerative role. The epidermal and dermal crosstalk induces morphogenesis and maintains hair follicle cycling properties. The hair follicle is enriched with pluripotent stem cells, where dermal papilla (DP) cells and dermal sheath (DS) cells constitute the dermal compartment and the epithelial stem cells existing in the bulge region exert their regenerative role by mediating the epithelial-mesenchymal interaction (EMI).

Increased Risk of End-Stage Kidney Disease After Traumatic Amputation: Nationwide Cohort Study.

Background: Amputation confers disabilities upon patients and is associated with substantial cardiovascular and metabolic morbidity and mortality. We aimed to compare the incidence of end-stage kidney disease (ESKD) between individuals with amputation and the general population.

Methods: A population-based retrospective cohort study was performed using the Nationwide Health Insurance Service database for the period between 2010 and 2018.

The Effect of Home-Based Robotic Rehabilitation on Individuals with Disabilities in Community Settings: A Pilot Study.

With South Korea's growing aging population, the demand for accessible rehabilitation solutions is increasing. Home-based robotic rehabilitation presents a feasible alternative to conventional in-clinic rehabilitation. This study explores the impact of the Rebless robotic rehabilitation device in a home-based setting for people with physical disabilities and their caregivers.

Perspective on Leisure Sports Participation Among Older Adults in a Super-Aging Society: Focusing on Health Concern, Athletic Passion, Leisure Satisfaction, and Intent to Continue Participating in Leisure Sports.

Today, society has a growing interest in healthy aging. This study analyzed health concerns, leisure satisfaction, athletic passion, and intention to continue participating in leisure sports of various age groups as well as the elderly, and we empirically analyzed the differences. : This study conducted a survey of 306 adult men and women who regularly participated in leisure sports.

A Study on Adolescent Smoking Prevention and Cessation Policies: Based on the Propensity Score Matching-Difference-in-Differences Method.

: Adolescent smoking can lead to various health problems including atherosclerosis and cardiovascular disease, making it more difficult to quit smoking during adulthood. This study aims to evaluate the effect of the ordinance by assessing adolescents' smoking cessation behaviors and environmental conditions, according to the "Ordinance for the Prevention of Child and Adolescent Smoking and Support for Smoking Cessation", which was enacted in 2019 in Gwangju City, South Korea, for the first time in the country. : The data for the analysis were obtained from the 2018 and 2021 Korea Youth Risk Behavior Survey.

Correlation Study Between TV Viewing Variables and Cognitive Level, Depression Level, and Activities of Daily Living in Older Individuals Living Alone.

Although there are studies on TV viewing and the health status of elderly, they do not present direct associations with specific variables. The aim of this study was to determine correlations between TV viewing variables and elderly health variables in older adults living alone. Data were collected from 50 elderly individuals with an average age of 82.

A multicenter micro-costing analysis of flexible cystoscopic procedures in Korea.

Purpose: This study aims to develop and implement an economic evaluation using a micro-costing approach to provide a precise and transparent analysis of the direct costs of cystoscopic procedures in Korean hospitals. The study seeks to identify key cost components and evaluate whether current reimbursement rates accurately reflect these direct costs.

Materials And Methods: Significant variations in cost items were identified across different studies.

Incidence and mortality of upper tract urothelial carcinoma in Korea: A nationwide population-based study conducted from 2002 to 2020.

Purpose: To describe the incidence and mortality of upper tract urothelial carcinoma (UTUC) from 2002-2020 using data from the Korean National Health Insurance Service, which contains data from the entire Korean population.

Materials And Methods: Reimbursement records for 43,255 patients diagnosed with primary UTUC (according to the International Classification of Disease 10th revision code C65 and C66) between 2002-2020 were retrieved. The study period was split into four: period I (2002-2005), period II (2006-2010), period III (2011-2015), and period IV (2016-2020).

Self-Assembly of Amorphous 2D Polymer Nanodiscs with Tuneable Size, pH-Responsive Degradation and Controlled Drug Release.

Amphiphilic bottlebrush block copolymers (BBCs) with tadpole-like, coil-rod architecture can be used to self-assemble into functional polymer nanodiscs directly in water. The hydrophobic segments of the BBC were tuned via the ratio of ethoxy-ethyl glycidyl ether (EE) to tetrahydropyranyl glycidyl ether (TP) within the grafted polymer sidechains. In turn, this variation controlled the sizes, pH-responsiveness, and drug loading capacity of the self-assembled nanodiscs.

Minimum number of readings necessary for determining long-term visit-to-visit blood pressure variability to predict cardiovascular outcomes in people with diabetes.

Background: People with diabetes often have increased blood pressure (BP) variability because of autonomic dysfunction and arterial stiffness, making it a critical factor in predicting clinical outcomes. We investigated the reproducibility of long-term visit-to-visit BP variability (VVV) and the minimum number of BP readings to reliably determine VVV in people with diabetes.

Methods: This multicenter retrospective study used data from electronic health records of the Korea University Medical Center database.

Parabrachial CGRP neurons modulate active defensive behavior under a naturalistic threat.

Recent studies suggest that calcitonin gene-related peptide (CGRP) neurons in the parabrachial nucleus (PBN) represent aversive information and signal a general alarm to the forebrain. If CGRP neurons serve as a true general alarm, their activation would modulate both passive nad active defensive behaviors depending on the magnitude and context of the threat. However, most prior research has focused on the role of CGRP neurons in passive freezing responses, with limited exploration of their involvement in active defensive behaviors.

Resolution of hypertension after kidney transplantation is associated with improved kidney transplant outcomes: a nationwide cohort study.

Objectives: Patients with advanced chronic kidney disease suffer from hypertension, and kidney transplantation (KT) has potential to induce hypertension resolution. We hypothesized that hypertension resolution after KT is associated with better KT outcomes.

Methods: We identified KT recipients (2006-2015) who had pretransplant hypertension.

Linking structural and rheological memory in disordered soft materials.

Linking the macroscopic flow properties and nanoscopic structure is a fundamental challenge to understanding, predicting, and designing disordered soft materials. Under small stresses, these materials are soft solids, while larger loads can lead to yielding and the acquisition of plastic strain, which adds complexity to the task. In this work, we connect the transient structure and rheological memory of a colloidal gel under cyclic shearing across a range of amplitudes a generalized memory function using rheo-X-ray photon correlation spectroscopy (rheo-XPCS).

One-Step Synthesis of 2-Arylquinolin-4(1)-Ones from 1-(2-Aminoaryl)-3-Arylpropan-1-Ones via Pd(II)-Catalyzed Dehydrogenative Cyclization.

In this study, we developed palladium-catalyzed dehydrogenative cyclization to transform 1-(2-aminoaryl)-3-arylpropan-1-ones into 2-arylquinolin-4(1)-ones, also known as aza-flavones which are the bioisosteres of flavones, in an atom-economic manner. This method exhibited excellent chemical compatibility with a broad substrate scope, accommodating up to 25 derivatives. Additionally, kinetic studies were performed to elucidate the reaction mechanism.

Torsion of Extralobar Pulmonary Sequestration Presenting as Posterior Mediastinal Mass.

Torsion of extralobar pulmonary sequestration is a rare congenital anomalous condition that can manifest with various symptoms, including abdominal pain. However, a masslike lesion in the mediastinum can be easily overlooked when the clinician focuses only on abdominal pain. By using magnetic resonance imaging, a few features specific to the torsion of extralobar pulmonary sequestration can be identified, and that information will be helpful.

Voxel-Based Morphometry and Subfield Volumetry Analysis Reveal Limbic System Involvement in Tinnitus.

Background And Purpose: Tinnitus is a condition in which individuals perceive sounds, such as ringing or buzzing, without any external source. Although the exact cause is not fully understood, recent studies have indicated the involvement of nonauditory brain structures, including the limbic system. We aimed to compare the volumes of specific brain structures between patients with tinnitus and controls.

Mental Health Status and Related Factors of Citizens 6 Months after Mass Death and Injury Due to Crowd Crush Incident: Focused on the Itaewon Disaster in 2022.

Objective: Crowd crush disasters result in psychological risks such as anxiety, depression, and post-traumatic stress disorder (PTSD). This descriptive research study identified the mental health status of Koreans after the Itaewon crowd crush disaster and explored related factors.

Methods: Data were collected May 2-9, 2023 using an online survey.

In Vitro Selection of Collagen-Binding Vascular Endothelial Growth Factor Containing Genetically Encoded Mussel-Inspired Adhesive Amino Acids.

Protein immobilization technology is important in medical and industrial applications. We previously reported all-in-one in vitro selection, wherein a collagen-binding vascular endothelial growth factor (CB-VEGF) was identified from a fusion library of random and VEGF sequences. However, its interaction chemistry is mainly limited to the interaction established by the 20 canonical amino acids.

Salt stress-accelerated proteasomal degradation of LBD11 suppresses ROS-mediated meristem development and root growth in Arabidopsis.

Roots absorb water and nutrients from the soil, support the plant's aboveground organs, and detect environmental changes, making them crucial targets for improving crop productivity. Roots are particularly sensitive to soil salinity, a major abiotic stress that poses a serious threat to global agriculture. In response to salt stress, plants suppress root meristem size, thus reducing root growth; however, the mechanisms underlying this growth restriction remain unclear.

The Korean integrative family therapy model.

Family therapy was introduced in South Korea in the 1970s and has been extensively applied in clinical and academic settings. However, despite the efficacy of using family therapy models from the United States for Korean families, existing models are unable to fully capture the nuances of the Korean family culture, limiting their full potential to help families in crises. Based on observations and counseling of over 1500 families in Korea, this paper presents a theoretical and clinical foundation, namely, the Korean Integrative Family Therapy Model.

Molecular characterization of swine acute diarrhea syndrome coronavirus detected in Vietnamese pigs.

Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a novel porcine coronavirus that was recently identified in southern China in 2017. At present, there is a lack of nationwide epidemiological investigations of the newly emerged SADS-CoV. Because Vietnam is geographically adjacent to southern China, many diseases have spread from China to Vietnam.

Secreted LGALS3BP facilitates distant metastasis of breast cancer.

Background: Patients with estrogen receptor (ER)-positive breast cancer (BC) can be treated with endocrine therapy targeting ER, however, metastatic recurrence occurs in 25% of the patients who have initially been treated. Secreted proteins from tumors play important roles in cancer metastasis but previous methods for isolating secretory proteins had limitations in identifying novel targets.

Methods: We applied an in situ secretory protein labeling technique using TurboID to analyze secretome from tamoxifen-resistant (TAMR) BC.

The effects of mobile phone addiction on learning engagement of Chinese college students - the mediating role of physical activity and academic self-efficacy.

Background: With the widespread adoption of smartphones, mobile phone addiction has increasingly gained prominence among Chinese college students, exerting a profound and detrimental impact on their learning engagement. This study employs self-determination theory as a framework to examine the mechanisms through which mobile phone addiction affects students' learning engagement. Specifically, it examines the mediating effects of physical activity and academic self-efficacy in this relationship.