Critical windows for exposure to chemical composition of ambient particulate matter and human semen quality decline.

Background: Critical windows for exposure to chemical components of particulate matter (PM <2.5 μm in diameter [PM]) associated with the human semen quality decline remain unclear.

Objectives: To address this gap, we developed a new analytical framework by integrating a Linear Mixed Model (LMM) with subject- and center-specific intercepts and a Distributed Lag Model (DLM) to fully account for correlations between finely vulnerable exposure windows based on complete profile of the spermatogenesis cycle.

Beneficial effect of residential greenness on sperm quality and the role of air pollution: A multicenter population-based study.

Background: Poor sperm quality is a major cause of male infertility. However, evidence remains scarce on how greenness affects male sperm quality.

Objectives: To assess the associations of residential greenness with male sperm quality and the modification effect of air pollution exposure on the relationship.

Assessing the reduction of viral infectivity in HPV16/18-positive women after one, two, and three doses of Gardasil-9 (RIFT): Study protocol.

Human Papillomavirus (HPV) prophylactic vaccination has proven effective in preventing new infections, but it does not treat existing HPV infections or associated diseases. Hence, there is still an important reservoir of HPV in adults, as vaccination programs are mainly focused on young women. The primary objective of this non-randomized, open-label trial is to evaluate if a 3-dose regimen of Gardasil-9 in HPV16/18-positive women could reduce the infective capacity of their body fluids.

Effects of temperature anomaly on sperm quality: A multi-center study of 33,234 men.

Backgrounds: Global fertility rates continue to decline and sperm quality is a prime factor affecting male fertility. Both extreme cold and heat have been demonstrated to be associated with decreased sperm quality, but no epidemiological studies have considered human adaptation to long-term temperature. Our aim was to conduct a multi-center retrospective cohort study to investigate exposure-response relationship between temperature anomaly (TA) that deviate from long-term climate patterns and sperm quality.

Sperm quality decline associated with gaseous pollutant exposure: Evidence from a large cohort multicenter study.

Background: Poor sperm quality is a prevalent cause of male infertility, and the association between gaseous ambient air pollutants exposure and semen quality remains unclear.

Objectives: To examine the relationship between gaseous air pollution exposure with semen quality in a large-scale and multi-center study.

Methods: We analyzed 78,952 samples corresponding to 33,234 study subjects from 2014 to 2020.

Exposure to Fine Particulate Matter Constituents and Human Semen Quality Decline: A Multicenter Study.

Exposure to fine particulate matter (PM < 2.5 μm in diameter [PM]) may accelerate human sperm quality decline, although research on this association is limited. Our objective was to investigate the relationship between exposure to the chemical constituents of PM air pollution and decreased sperm quality and to further explore the exposure-response relationship.

Overview of maternal and perinatal mortality in Sudan.

The Millennium Development Goals (MDGs), agreed on by world leaders at a UN summit in 2000, set targets to achieve by 2015. MDGs 4 and 5 specifically focus on the health of women and children. Sudan is classified as having insufficient progress in achieving MDGs 4 and 5.