200 results match your criteria: "Repetitive Head Injury Syndrome"
Examination of plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation in former elite American football players.
Alzheimers Dement
November 2024
Boston University CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Article Synopsis
- - Blood-based biomarkers are being explored to detect brain injuries from repetitive head impacts, specifically in former football players, by analyzing plasma levels of various proteins like tau and amyloid.
- - A study involving 180 former football players and 60 control participants found that specific biomarkers (p-tau181 and p-tau231) were significantly elevated in the football players, indicating potential brain damage linked to their sport.
- - The findings suggest that certain plasma proteins (p-tau, GFAP, NfL) could help in understanding and identifying neurological issues related to head impacts, with younger players showing more severe biomarker changes.
Epidemiological Principles in Claims of Causality: An Enquiry into Repetitive Head Impacts (RHI) and Chronic Traumatic Encephalopathy (CTE).
Sports Med
September 2024
New Zealand Rugby, 100 Molesworth Street, Wellington, New Zealand.
Article Synopsis
- The global sports medicine community is interested in understanding if repetitive head impacts (RHI) lead to chronic traumatic encephalopathy (CTE) and its related clinical syndromes.
- A 2022 article claimed to provide definitive proof of causality between RHI and CTE using the Bradford Hill criteria, sparking significant media attention.
- However, the authors of this counterpoint argue that the evidence is insufficient to support those claims and stress the need for precise definitions, consistent measurements, and well-designed studies before establishing any causal links.
Cavum Septum Pellucidum in Former American Football Players: Findings From the DIAGNOSE CTE Research Project.
Neurol Clin Pract
October 2024
Department of Rehabilitation Medicine (HA, OJ), New York University Grossman School of Medicine, New York, NY; NYU Concussion Center (HA), NYU Langone Health, New York, NY; Psychiatry Neuroimaging Laboratory (HA, LBJ, OJ, NK, HWC, EK, AC, TLTW, TB, OP, MJC, IKK, SB, MES), Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; cBRAIN (LBJ, TLTW, IKK), Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital, Ludwig-Maximilians-Universit¨at, Munich, Germany; Department of Biostatistics (FT-Z, YT), Boston University School of Public Health Boston, MA; Center for Clinical Spectroscopy (KB, APL), Department of Radiology, Brigham and Women's Hospital Boston, MA; Department of Physical Medicine and Rehabilitation (DD), Harvard Medical School Boston, MA; Department of Physical Medicine and Rehabilitation (DD), Massachusetts General Hospital Boston, MA; Department of Physical Medicine and Rehabilitation (DD), Spaulding Rehabilitation Hospital, Cambridge, MA; Department of Radiology (OP, APL, MES), Brigham and Women's Hospital, Harvard Medical School Boston, MA; Department of Psychiatry (OP, IKK, MES), Massachusetts General Hospital Boston, MA; Department of Neurology (CHA), Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ; Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV (CB); Department of Neurology (CB), University of Washington, Seattle, WA; Department of Neurology (LJB), New York University Grossman School of Medicine, New York, NY; Department of Population Health (LJB), New York University Grossman School of Medicine, New York, NY; Department of Ophthalmology (LJB), New York University Grossman School of Medicine, New York, NY; Department of Neurology (MLA, RAS), Boston University Alzheimer's Disease Research Center and CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA; Graduate School of Systemic Neurosciences (IKK), Ludwig-Maximilians-Universität, Munich, Germany; Chambers-Grundy Center for Transformative Neuroscience (JLC), Pam Quirk Brain Health and Biomarker Laboratory, Department of Brain Health, School of Integrated Health Sciences, University of Nevada Las Vegas, Las Vegas, NV; Banner Alzheimer's Institute and Arizona Alzheimer's Consortium (EMR), Phoenix, AZ; Department of Psychiatry (EMR), University of Arizona, Tucson, AZ; Department of Psychiatry (EMR), Arizona State University, Phoenix, AZ; Neurogenomics Division (EMR), Translational Genomics Research Institute and Alzheimer's Consortium, Phoenix, AZ; Department of Anatomy and Neurobiology (RAS); Department of Neurosurgery (RAS), Boston University Chobanian & Avedisian School of Medicine, Boston, MA; and Department of Software Engineering and Information Technology (SB), École de technologie supérieure, Université du Québec, Montreal, Canada.
Article Synopsis
- Exposure to repetitive head impacts (RHI) correlates with chronic traumatic encephalopathy (CTE), which can only be diagnosed after death; the study explores the presence of a cavum septum pellucidum (CSP) in living former football players to understand its relation to RHI and potential CTE.
- The research involved 175 former players, both college and professional, and compared their CSP measurements to a control group without RHI exposure, assessing associations with cumulative head impact and traumatic encephalopathy syndrome (TES).
- Results indicated that former players had significantly higher CSP presence and ratio compared to controls, with professional players exhibiting an even greater ratio; however, there was no notable link between CSP and TES or provisional
Characterizing Neurobehavioral Dysregulation Among Former American Football Players: Findings From the DIAGNOSE CTE Research Project.
J Neuropsychiatry Clin Neurosci
July 2024
Chronic Traumatic Encephalopathy Center (Pulukuri, Fagle, Trujillo-Rodriguez, van Amerongen, Katz, Alosco, Tripodis, Stern), Graduate Program in Neuroscience (Trujillo-Rodriguez), Department of Neurology (Katz, Alosco, Stern), Alzheimer's Disease Research Center (Alosco, Tripodis, Stern), Department of Neurosurgery and Department of Anatomy and Neurobiology (Stern), Boston University Chobanian and Avedisian School of Medicine, Boston; Department of Neurology, Alzheimer Center Amsterdam, Vrije Universiteit (VU) Amsterdam, VU University Medical Center, and Department of Neurodegeneration, Amsterdam Neuroscience, Amsterdam (van Amerongen); Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas (Bernick); Department of Neurology and the Franke Global Neuroscience Education Center, Barrow Neurological Institute, Phoenix (Geda); Department of Psychiatry and Psychology (Wethe) and Department of Neurology (Adler), Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale; Veterans Affairs Northwest Mental Illness Research, Education, and Clinical Center and Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Peskind); Brain Injury Program, Encompass Health Braintree Rehabilitation Hospital, Braintree, Mass. (Katz); Biostatistics and Epidemiology Data Analytics Center (Palmisano) and Department of Biostatistics (Tripodis), Boston University School of Public Health; Departments of Neurology, Population Health, and Ophthalmology, New York University Grossman School of Medicine, New York (Balcer); Banner Alzheimer's Institute, University of Arizona, Translational Genomics Research Institute, Arizona State University, and Arizona Alzheimer's Consortium, Phoenix (Reiman); Departments of Psychiatry and Radiology, Psychiatry Neuroimaging Laboratory, Harvard Medical School, Brigham and Women's Hospital, Boston (Shenton); Department of Brain Health, Chambers-Grundy Center for Transformative Neuroscience, School of Integrated Health Sciences, University of Nevada Las Vegas (Cummings).
Article Synopsis
- The study investigates neurobehavioral dysregulation (NBD), which includes neuropsychiatric symptoms linked to repetitive head impacts, particularly in former contact sport athletes.
- Through analyses involving questionnaires from 178 former football players, researchers identified four subconstructs of NBD: explosivity, emotional dyscontrol, impulsivity, and affective lability.
- The results revealed four symptom profiles among participants, highlighting the complexity of NBD and serving as a basis for future research on its diagnostic criteria and neurobiological aspects.
Personalized, parcel-guided non-invasive transcranial magnetic stimulation for the treatment of post-concussive syndrome: safety and proof of concept.
Brain Inj
October 2024
Cingulum Health, Sydney, Australia.
Article Synopsis
- The study aims to evaluate the safety and effectiveness of a targeted form of Transcranial Magnetic Stimulation (rTMS) in patients suffering from post-concussive syndrome (PCS) after traumatic brain injuries (TBI).
- Researchers reviewed the experiences of 19 patients who underwent personalized rTMS treatment, identifying targets using advanced machine learning techniques to improve their quality of life and reduce symptoms.
- Results indicated significant improvements in overall well-being and reductions in symptoms of depression and anxiety among the patients, suggesting that this method could be a promising treatment for PCS, warranting further research.
History of biological, mechanistic, and clinical understanding of concussion.
Neurosurg Focus
July 2024
Article Synopsis
- The text traces the historical development of understanding concussions, starting from their first description in the 10th century to modern insights about their long-term effects.
- It highlights the pivotal work of Dr. Harrison Martland in 1928, who linked repeated head injuries in boxers to the development of chronic symptoms, coining the term "punch drunk."
- The authors emphasize the need for further research on preventive and therapeutic measures for concussions, particularly due to the risks associated with chronic traumatic encephalopathy in athletes and military personnel.
Symptoms of Traumatic Encephalopathy Syndrome are Common in Community-Dwelling Adults.
Sports Med
September 2024
Department of Neurological Surgery, Vanderbilt Sports Concussion Center, Vanderbilt University Medical Center, Suite 4340, 1500 21St Ave South, Nashville, TN, 37206, USA.
Article Synopsis
- - The study aimed to investigate the existence and prevalence of symptoms related to traumatic encephalopathy syndrome (TES) in healthy adults, exploring the link between repetitive head impacts and key clinical features.
- - Researchers conducted a survey among 1,100 participants, analyzing symptoms based on 2021 criteria, alongside factors such as concussion history and psychological health.
- - Results indicated that about 34.6% of participants reported symptoms of TES, with significant predictors including current depression and anxiety, psychiatric history, and sleep problems, rather than past contact sports participation.
Brain morphometry in former American football players: findings from the DIAGNOSE CTE research project.
Brain
October 2024
Department of Software Engineering and Information Technology, École de technologie supérieure, Université du Québec, Montréal, QC H3C 1K3, Canada.
Article Synopsis
- * A study evaluated brain structures using MRI in 170 former football players and 54 controls, assessing regions associated with CTE pathology, revealing significant reductions in cortical thickness and volume in players compared to controls.
- * Former professional players showed more pronounced brain changes than former college players, specifically in areas like the hippocampus and amygdala, indicating that exposure to head impacts has lasting effects on brain structure.
Shaking Up Our Approach: The Need for Characterization and Optimization of Pre-clinical Models of Infant Abusive Head Trauma.
J Neurotrauma
August 2024
Department of Neuroscience, Monash University, Melbourne, Victoria, Australia.
Article Synopsis
- Traumatic brain injuries (TBIs) significantly impact individuals and society, particularly in infants where abusive head trauma (AHT) is a leading cause of inflicted injury and death.
- The review focuses on diagnosing AHT, symptoms, prognosis, and its repetitive nature, alongside existing animal models and developmental milestones that make infants vulnerable.
- It also explores insights from other types of injuries to identify knowledge gaps in AHT research and discusses potential treatment options for impacted children to support their development.
Linking Type and Extent of Head Trauma to Cavum Septum Pellucidum in Older Adults With and Without Alzheimer Disease and Related Dementias.
Neurology
April 2024
From the Department of Clinical and Health Psychology (B.M.A.), University of Florida, Gainesville; Department of Neurology (J.A.T.), Biggs Institute for Alzheimer's and Neurodegenerative Diseases at UT Health San Antonio, TX; Department of Neurology (L.V., M.C., C.L.-D., G.Y., S. Lee, E.G., M.K., L.I., R.L.J., Y.C., A.M.S., K.B.C., L.T.G., M.L.G.-T., H.J.R., W.W.S., B.L.M., J.K., G.D.R.), Weill Institute for Neurosciences, Memory and Aging Center, and Department of Psychiatry (A.A.), University of California, San Francisco; Department of Geriatrics (L.S.G.), Vanderbilt University Medical Center, Nashville, TN; Department of Neurology (S. Lenio), Boston University Medical Center, MA; and Sheba Medical Center at Tel Hashomer (R.C.G.), Ramat Gan, Israel.
Background And Objectives: Cavum septum pellucidum (CSP) is a common but nonspecific MRI finding in individuals with prior head trauma. The type and extent of head trauma related to CSP, CSP features specific to head trauma, and the impact of brain atrophy on CSP are unknown. We evaluated CSP cross-sectionally and longitudinally in healthy and clinically impaired older adults who underwent detailed lifetime head trauma characterization.
View Article and Find Full Text PDFThis study psychometrically evaluated the Neurobehavioral Symptom Inventory (NSI) among women survivors of intimate partner violence (IPV) and compared symptoms between women with no brain injury history ( = 93) and women with IPV-related brain injury history ( = 112). Women completed the NSI and questionnaires on traumatic brain injury (TBI), hypoxic-ischemic brain injury (HI-BI), and lifetime IPV history. A four-factor NSI model, including affective, somatosensory, cognitive, and vestibular factors, had the best fit (comparative fit index = 0.
View Article and Find Full Text PDFRepetitive head impacts among professional fighters: a pilot study evaluating Traumatic Encephalopathy Syndrome and postural balance.
Phys Sportsmed
October 2024
Department of Neurology, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.
Article Synopsis
- Researchers looked at whether retired fighters with Traumatic Encephalopathy Syndrome (TES) had worse balance than those without it.
- They found that fighters who had many head impacts (like from fighting) were more likely to have TES and struggle with balance.
- The study suggests that having a lot of fights can increase the chances of getting TES, and they want to do more research to understand balance better in these athletes.
Inflammatory biomarkers for neurobehavioral dysregulation in former American football players: findings from the DIAGNOSE CTE Research Project.
J Neuroinflammation
February 2024
Boston University CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Article Synopsis
- Traumatic encephalopathy syndrome (TES) is linked to chronic traumatic encephalopathy (CTE) and is characterized by neurobehavioral dysregulation (NBD), impacting emotional and behavioral regulation in individuals exposed to repetitive head impacts, like former American football players.
- The study involved 104 former players diagnosed with NBD, 76 without the diagnosis, and 55 unexposed individuals, using self-report measures to assess NBD symptoms and cerebrospinal fluid (CSF) biomarkers associated with inflammation.
- Results indicated that levels of the pro-inflammatory cytokine IL-6 were significantly higher in former players, suggesting a connection between these inflammation markers and NBD symptoms linked to past head impacts.
Examining the New Consensus Criteria for Traumatic Encephalopathy Syndrome in Community-Dwelling Older Adults.
J Neurotrauma
April 2024
Vanderbilt Sports Concussion Center, Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Article Synopsis
- The study involved 507 older adults to analyze the relationship between repetitive head impacts from contact sports and TES symptoms, finding that only about 26% of participants showed signs of TES.
- Current mental health issues like depression or anxiety, as well as a history of psychiatric disorders, were strongly associated with TES symptoms, while prior contact sport exposure didn't significantly impact the likelihood of meeting TES criteria.
Navigating the Complexities of Traumatic Encephalopathy Syndrome (TES): Current State and Future Challenges.
Biomedicines
November 2023
Department of Neurology and Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA.
Article Synopsis
- - Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease linked to repetitive head injuries, with new criteria established in 2014 to help identify its clinical manifestations known as traumatic encephalopathy syndrome (TES).
- - The review discusses the current understanding of CTE's neuropathological and clinical features, the challenges in diagnosing traumatic brain injury (TBI) due to variability, and potential biomarkers and treatments from past studies.
- - As research progresses, better diagnostic methods and treatments for CTE are anticipated, highlighting the importance of addressing the links between TBI and other neurodegenerative diseases like Alzheimer's, and emphasizing the need for increased awareness and research in this area.
Flortaucipir tau PET findings from former professional and college American football players in the DIAGNOSE CTE research project.
Alzheimers Dement
March 2024
Banner Alzheimer's Institute and Arizona Alzheimer's Consortium, Phoenix, Arizona, USA.
Article Synopsis
- - The study investigates tau pathology in chronic traumatic encephalopathy (CTE) using tau PET imaging from 218 participants, including former professional and college football players, and a control group of individuals without head impact exposure.
- - Elevated tau levels were found in former football players compared to controls, especially in older players over 60 with cumulative head impact exposure, but PET imaging didn't effectively distinguish between individuals with and without traumatic encephalopathy syndrome.
- - The authors emphasize the need for further research to better understand the link between tau pathology and chronic traumatic brain injuries, as current findings only partially clarify these relationships.
Examination of parkinsonism in former elite American football players.
Parkinsonism Relat Disord
March 2024
Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Department of Anatomy & Neurobiology, Boston University Chobanian & Avedisian, Boston, MA, USA.
Article Synopsis
- Former football players are at risk for chronic traumatic encephalopathy (CTE), which can include parkinsonism as a clinical feature.
- A study assessed 120 former professional and 58 college football players, comparing them to 60 similar-aged men without repetitive head impacts, to investigate rates of parkinsonism.
- Results showed that 12.4% of football players met parkinsonism criteria, with a higher prevalence in professional players, but overall rates were low and inconclusive regarding the effects of football exposure on parkinsonism.
Adult-Onset Tics After Being Crushed by an Air Conditioner: A Case Report.
Cureus
September 2023
Movement Disorders, University of Iowa Hospitals and Clinics, Iowa City, USA.
Article Synopsis
- Tics are involuntary, repetitive movements or sounds that typically emerge in childhood and are most commonly associated with Tourette syndrome (TS).
- A case study is presented of a 30-year-old man who began experiencing motor and vocal tics two weeks after sustaining a closed head injury from being crushed by a heavy object.
- The patient's tics worsened over several months, but treatment with pimozide and hyperbaric oxygen therapy led to improvement in his symptoms.
Repetitive Head Injury and Cognitive, Physical, and Emotional Symptoms in Women Survivors of Intimate Partner Violence.
J Neurotrauma
February 2024
Department of Behavioral Science, University of Kentucky, Lexington, Kentucky, USA.
Article Synopsis
- Many women who experience intimate partner violence (IPV) suffer from repeated head injuries, but research on how these injuries affect their well-being is limited.
- This study focused on the relationship between the number of lifetime head injuries and the severity of cognitive, physical, and emotional symptoms in IPV survivors in Kentucky, involving interviews with 518 women.
- Findings revealed that a higher number of head injuries and loss of consciousness episodes were linked to increased physical and sexual IPV severity, as well as greater cognitive, physical, and emotional symptom severity.
The shoulder joint complex in the throwing motion.
J Shoulder Elbow Surg
February 2024
Shoulder Center of Kentucky, Lexington Clinic, Lexington, KY, USA.
Article Synopsis
- * The coupling of movements between the scapula, clavicle, and humerus creates an important mechanism known as scapulohumeral rhythm (SHR), which is essential for achieving specific arm positions for optimal performance.
- * Disruptions in this coordinated movement, known as scapular dyskinesis, can lead to inefficient shoulder function and increase the risk of injury, particularly through changes in scapular positioning and humeral motion.
Head Injury Due to Intimate Partner Violence: Injury Characteristics, Subacute Symptoms, and Receipt of Care.
J Neurotrauma
February 2024
Department of Behavioral Science, University of Kentucky, Lexington, Kentucky, USA.
Article Synopsis
- - The study focuses on women survivors of intimate partner violence (IPV) and their increased risk for repetitive neurotrauma, comparing those with IPV-related head injuries to those with head injuries from other causes using data from interviews in Kentucky (2001-2004).
- - Results show that women with IPV-related head injuries reported significantly more lifetime head injuries and instances of loss of consciousness compared to those with non-IPV-related head injuries, indicating greater severity of injury.
- - Despite having worse injury outcomes, women with IPV-related head injuries were hospitalized and received rehabilitation less frequently than those with head injuries from other causes, highlighting gaps in care for IPV survivors.
Alzheimer's pathology is associated with altered cognition, brain volume, and plasma biomarker patterns in traumatic encephalopathy syndrome.
Alzheimers Res Ther
July 2023
Department of Neurology, Weill Institute for Neurosciences, Memory and Aging Center, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA, 94158, USA.
Article Synopsis
- Traumatic encephalopathy syndrome (TES) is linked to repetitive head impacts and presents cognitive symptoms similar to Alzheimer's disease (AD), complicating diagnosis due to overlapping neuropathological features.
- A study of 154 participants compared cognitive performance, brain volume, and plasma biomarkers among those with TES, AD, and healthy controls, revealing that Aβ[+] TES patients performed worse on specific cognitive tests compared to Aβ[-] TES patients.
- Results showed that both Aβ[+] and Aβ[-] TES groups had lower brain volumes in certain areas than healthy controls, but their volumes were similar to those of AD patients; additionally, Aβ[+] TES had higher levels of specific plasma biomarkers.
Lifetime Traumatic Brain Injury and Risk of Post-Concussive Symptoms in the Millennium Cohort Study.
J Neurotrauma
March 2024
Deployment Health Research Department, Naval Health Research Center, San Diego, California, USA.
Article Synopsis
- Traumatic brain injury (TBI) is common in active military personnel, with studies showing up to 23% have experienced at least one, and a significant number reporting multiple TBIs.
- There’s a concerning link between the number of TBIs and long-term neurobehavioral symptoms, affecting both short-term operational readiness and long-term health.
- A study using data from over 28,000 service members found that as the number of lifetime TBIs increased, so did the prevalence of post-concussive symptoms (PCS), highlighting the need for more thorough examination in military populations.