10,233 results match your criteria: "Renovascular Hypertension"
Chronic mesenteric ischemia, renovascular hypertension and critical limb threatening ischemia treated with thoraco-visceral and lower extremity bypass: Major open surgical techniques will remain essential.
J Vasc Surg Cases Innov Tech
December 2024
Division of Vascular and Endovascular Surgery, Stony Brook University Hospital, Stony Brook, NY.
Article Synopsis
- * She underwent a major surgical procedure involving bypassing blocked arteries using a specialized graft to improve blood flow and alleviate her symptoms.
- * Nine months post-surgery, she showed significant improvement, highlighting the importance of careful planning and selecting suitable candidates for open surgery in cases of aortoiliac disease.
Severe hypertension in tuberous sclerosis complex caused by renal artery stenosis: A case report.
Nephrology (Carlton)
December 2024
Hemangioma and Vascular Anomaly Center, Capital Institute of Pediatrics, Beijing, China.
Article Synopsis
- - Tuberous sclerosis complex (TSC) is a rare genetic condition that can lead to various complications, including arterial hypertension caused by renal cysts or angiomyolipomas.
- - A case study highlights a boy with TSC who faced severe hypertension despite being on five anti-hypertensive medications; he was found to have left renal artery stenosis (RAS).
- - Following treatment with percutaneous transluminal renal angioplasty (PTRA), the boy's blood pressure normalized over a year and a half, suggesting the importance of screening TSC patients for RAS that may be treatable.
Computational Insights into Captopril's Inhibitory Potential Against MMP9 and LCN2 in Bladder Cancer: Implications for Therapeutic Application.
Cancer Inform
September 2024
Department of Bioinformatics and Biotechnology, Asian University for Women, Chattogram, Bangladesh.
Article Synopsis
- Captopril, widely used to treat various cardiovascular conditions, shows potential for bladder cancer patients with hypertension due to its interaction with relevant proteins associated with the disease.* -
- The study identified key protein targets of captopril using Bioinformatics tools, revealing that it effectively inhibits overexpressed genes like MMP9 and LCN2, which are linked to poor survival rates in bladder cancer.* -
- The research suggests further laboratory studies are needed to validate captopril's effectiveness in treating bladder cancer, highlighting its dual role in managing both hypertension and cancer-related complications.*
The incidence of hypertension among children after renal trauma: A matched cohort analysis.
J Pediatr Urol
December 2024
Department of Urology, University of Washington School of Medicine, Seattle, WA, USA; Harborview Injury Prevention Research Center, Seattle, WA, USA. Electronic address:
Article Synopsis
- The study aimed to compare the rates of new hypertension in children who experienced renal trauma to those who suffered isolated extremity fractures at a trauma center from 2010 to 2019.
- The researchers found that hypertension prevalence was similar between both groups, with 9.7-11.3% of patients experiencing hypertension and 22.6-32.3% showing elevated blood pressure.
- The conclusion suggests that while there is a risk of elevated blood pressure in pediatric trauma patients, renal trauma does not significantly increase the likelihood of developing hypertension, indicating that only a small number of these patients may need continued monitoring for this condition.
Prevalence and Risk Factors for Secondary Hypertension in Young Adults.
Hypertension
November 2024
Hypertension Unit (J.-B.d.F., M.G., S.C., G.B., N.G., A.L., C.M., A.-M.M., J.R., N.P.-V., M.A., L.A.), Hôpital Européen Georges Pompidou, AP-HP, Université Paris Cité, France.
Article Synopsis
- - The study focused on understanding how common secondary hypertension (2HTN) is in young adults aged 18 to 40, finding that nearly 30% of patients had 2HTN.
- - The most common causes of 2HTN were identified as primary aldosteronism, renovascular hypertension, and kidney diseases, with certain factors like being female and having a lower BMI linked to a higher prevalence.
- - Based on their findings, the researchers recommend that all young adults with hypertension should be screened for secondary causes, as there is a significant risk present regardless of age or blood pressure levels.
Management of Renovascular Hypertension and Renal Denervation in Patients with Hypertension: An Italian Nationwide Survey.
High Blood Press Cardiovasc Prev
September 2024
Division of Internal Medicine and Hypertension Unit, Department of Medical Sciences, University of Turin, Via Genova 3, 10126, Turin, Italy.
Introduction: Renovascular hypertension (RVH) remains underdiagnosed despite its significant cardiovascular and renal morbidity.
Aim: This survey investigated screening and management practices for RVH among hypertensive patients in Italian hypertension centres in a real-life setting. Secondary, we analysed the current spread of renal denervation (RDN) and the criteria used for its eligibility.
Carvacrol improves cognitive dysfunction by decreasing amyloid-β accumulation and regulating neuroinflammation in ovariectomized renovascular hypertensive rats.
Naunyn Schmiedebergs Arch Pharmacol
September 2024
Department of Pharmacology, Faculty of Pharmacy, Fenerbahçe University, Istanbul, Turkey.
Hypertension contributes to both the development and progression of brain damage and cognitive dysfunction in the postmenopausal period in women. Carvacrol (CAR), which can easily cross the blood-brain barrier, exhibits neuroprotective properties due to its antioxidant, anti-inflammatory, and anti-apoptotic effects. In the present study, we have examined the effect of CAR treatment on learning-memory impairment in a post-menopausal hypertensive rat model that was induced by ovariectomy following two-kidney, one-clip renovascular hypertension surgery.
View Article and Find Full Text PDFPharmacological effects of MT-1207 in bilateral renal artery stenosis hypertension and its hypotensive targets validation.
Biomed Pharmacother
September 2024
Department of Pharmacology, Second Military Medical University / Naval Medical University, Shanghai, China; School of Medicine, Shanghai University, Shanghai, China. Electronic address:
Article Synopsis
- * In experiments with rats using a two-kidney two-clip model, MT demonstrated significant antihypertensive effects, cardiovascular protection, improved kidney function, and potential benefits for uric acid levels and cognitive functions.
- * Unlike the angiotensin receptor blocker losartan, which worsened renal function, MT showed beneficial effects and appears to work by blocking certain receptors (α and 5-HT) that influence blood pressure.
Idebenone protects the kidneys of rats with renovascular arterial hypertension by inhibiting oxidative stress and apoptosis.
Cell Mol Biol (Noisy-le-grand)
July 2024
Department of Nephrology, Nanping First Hospital Affiliated to Fujian Medical University, Nanping 353000, China.
Here, the protective effect of antioxidant Idebenone (IDB) on renovascular hypertension was studied. The two-kidney one-clip (2K-1C) model of renal hypertension was established. The rats were divided into 3 groups: sham-operation group, 2K-1C renal hypertensive rats' model group and model treated with IDB group.
View Article and Find Full Text PDFBehcet's disease presenting as malignant hypertension induced by renovascular hypertension.
CEN Case Rep
July 2024
Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Article Synopsis
- * The patient exhibited severe hypertension (222/140 mmHg), along with symptoms like fever, weight loss, and visual impairment, prompting further investigations that revealed elevated inflammatory markers.
- * Diagnosis of vascular Behcet's disease was confirmed through recurrent oral lesions and positive tests; treatment included antihypertensive medications and colchicine for symptom management.
Activation of angiotensin converting enzyme 2 promotes hippocampal neurogenesis via activation of Wnt/β-catenin signaling in hypertension.
Mol Cell Neurosci
September 2024
Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow 226031, U.P., India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address:
Hypertension-induced brain renin-angiotensin system (RAS) activation and neuroinflammation are hallmark neuropathological features of neurodegenerative diseases. Previous studies from our lab have shown that inhibition of ACE/Ang II/AT1R axis (by AT1R blockers or ACE inhibitors) reduced neuroinflammation and accompanied neurodegeneration via up-regulating adult hippocampal neurogenesis. Apart from this conventional axis, another axis of RAS also exists i.
View Article and Find Full Text PDFRenovascular Disease and Mitochondrial Dysfunction in Human Mesenchymal Stem Cells.
J Am Soc Nephrol
November 2024
Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Article Synopsis
- - Renovascular disease negatively affects the ability of mesenchymal stem/stromal cells (MSCs) derived from human adipose tissue to repair ischemic kidneys in mice.
- - The study hypothesized that changes in the MSC transcriptome due to renovascular disease reduce their effectiveness in kidney repair, impacted by factors like associated atherosclerosis and hypertension.
- - Healthy MSCs demonstrated beneficial effects on blood pressure and kidney function, while those from patients with renovascular disease did not, indicating a need for interventions like miR-378h modulation to enhance MSC function.
Ile-Pro-Pro attenuates sympathetic activity and hypertension.
J Physiol Biochem
August 2024
Emergency Department, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210011, China.
Article Synopsis
- Isoleucine-proline-proline (IPP) is a natural tripeptide that inhibits angiotensin-converting enzyme (ACE), playing a role in reducing hypertension and sympathetic activity in a rat study.
- The study involved male Sprague-Dawley rats with induced hypertension, showing that IPP injections into the brain and bloodstream effectively lowered both sympathetic nerve activity and blood pressure by mitigating ACE activity and oxidative stress.
- Long-term treatment with IPP also led to significant reductions in hypertension and vascular changes, highlighting its potential as a therapeutic approach for managing high blood pressure.
Activation AMPK in Hypothalamic Paraventricular Nucleus Improves Renovascular Hypertension Through ERK1/2-NF-κB Pathway.
Cardiovasc Toxicol
September 2024
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center; Institute of Cardiovascular Sciences, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center; Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Ministry of Education, Xi'an, 710061, Shaanxi, China.
Article Synopsis
- * In experiments with hypertensive rats, researchers discovered decreased AMPK activity alongside increased levels of AT1-R (a receptor linked to hypertension) and ERK1/2 proteins in the PVN.
- * Administering an AMPK activator, AICAR, helped lower blood pressure and sympathetic nerve activity, suggesting that stimulating AMPK can reduce AT1-R expression and improve hypertension by blocking certain signaling pathways in the PVN.
The Total Denervation of the Ischemic Kidney Induces Differential Responses in Sodium Transporters' Expression in the Contralateral Kidney in Goldblatt Rats.
Int J Mol Sci
June 2024
Cardiovascular Division, Department of Physiology, School of Medicine, Federal University of Sao Paulo, Sao Paulo 04023-060, Brazil.
The Goldblatt model of hypertension (2K-1C) in rats is characterized by renal sympathetic nerve activity (rSNA). We investigated the effects of unilateral renal denervation of the clipped kidney (DNX) on sodium transporters of the unclipped kidneys and the cardiovascular, autonomic, and renal functions in 2K-1C and control (CTR) rats. The mean arterial pressure (MAP) and rSNA were evaluated in experimental groups.
View Article and Find Full Text PDFAntihypertensive and Antioxidant Effects of an Aqueous Extract of Asafetida in Renovascular Hypertensive Rats.
Saudi J Kidney Dis Transpl
December 2023
Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Recently, the effect of an aqueous extract of asafetida on acute angiotensin II hypertensive rats was evaluated. The present study evaluated the antihypertensive and antioxidant effects of asafetida on a rat model of renovascular hypertension (RVH) using four groups. RVH was induced by clipping the renal artery; the sham group underwent surgery but without clipping.
View Article and Find Full Text PDFNew ways of mitigating aldosterone in cardiorenal disease.
Eur Heart J Cardiovasc Pharmacother
October 2024
Department of Internal Medicine III-Cardiology, Angiology and Intensive Care Medicine, Homburg University Hospital, Saarland University, Kirrberger Str. 100, Homburg 66424, Germany.
Article Synopsis
- Steroidal mineralocorticoid receptor antagonists (MRAs) help manage conditions like heart failure and chronic kidney disease by blocking aldosterone, but they may have significant side effects and limited effectiveness in some types of heart failure.
- New non-steroidal MRAs, like finerenone, show promise in improving outcomes for patients with diabetic nephropathy and heart failure, with guidelines recommending their use in type 2 diabetes and chronic kidney disease.
- Other investigational drugs, such as baxdrostat and lorundostat, are being tested for their effectiveness in treating resistant hypertension without the adverse effects associated with steroidal MRAs.
Gstp1 negatively regulates blood pressure in hypertensive rat via promoting APLNR ubiquitination degradation mediated by Nedd4.
Clin Sci (Lond)
July 2024
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210023, China.
Article Synopsis
- * In experiments with rats, they found that higher amounts of Gstp1 in arteries were linked to higher blood pressure, and changing Gstp1 levels affected the rats' blood pressure.
- * The study shows that Gstp1 could help lower high blood pressure, and understanding how it works might lead to new ways to treat hypertension in people.
Fenofibrate reduces cardiac remodeling by mitochondrial dynamics preservation in a renovascular model of cardiac hypertrophy.
Eur J Pharmacol
September 2024
Department of Pharmaceutical Sciences, University of Milan, Milan, Italy. Electronic address:
Fenofibrate, a PPAR-α agonist clinically used to lower serum lipid levels, reduces cardiac remodeling and improves cardiac function. However, its mechanism of action is not completely elucidated. In this study we examined the effect of fenofibrate on mitochondria in a rat model of renovascular hypertension, focusing on mediators controlling mitochondrial dynamics and autophagy.
View Article and Find Full Text PDFMid-aortic syndrome presented as dilated cardiomyopathy.
BMJ Case Rep
June 2024
Hospital Sultan Idris Shah Serdang, Kajang, Selangor, Malaysia.
Article Synopsis
- * A young girl initially diagnosed with heart failure due to dilated cardiomyopathy was later found to have MAS after a follow-up echocardiogram revealed abnormalities.
- * CT angiography confirmed a narrow section of her aorta, leading to successful treatment with stenting, which improved her heart function and emphasized the need for thorough assessments for treatable heart conditions.
Role of plasmacytoid dendritic cells in vascular dysfunction in mice with renovascular hypertension.
Heliyon
June 2024
Eastern Virginia Medical School, Department of Physiological Sciences, 800 W Olney Rd, Norfolk, VA 23501, USA.
Endothelial dysfunction and inflammation are clinically significant risk factors for cardiovascular diseases in hypertension. Although immune cells play a role in hypertension, the impact of plasmacytoid dendritic cells in established renovascular hypertension-induced cardiovascular complications is not fully understood. We investigated plasmacytoid dendritic cells' contribution to arterial endothelial dysfunction and inflammation in renovascular hypertension.
View Article and Find Full Text PDFThe hydrogen sulfide donor 4-carboxyphenyl-isothiocyanate decreases blood pressure and promotes cardioprotective effect through reduction of oxidative stress and nuclear factor kappa B/matrix metalloproteinase (MMP)-2 axis in hypertension.
Life Sci
August 2024
Department of Pharmacology, Brazil. Electronic address:
Aims: Our aim was to evaluate whether the hydrogen sulfide (HS) donor, 4-carboxyphenyl-isothiocyanate (4-CPI), exerts cardioprotective effect in the two kidney- one clip (2K-1C) rats through oxidative stress and MMP-2 activity attenuation and compare it with the classical HS donor, Sodium Hydrosulfide (NaHS).
Materials And Methods: Renovascular hypertension (two kidneys-one clip; 2K-1C) was surgically induced in male Wistar rats. After two weeks, normotensive (2K) and hypertensive rats were intraperitoneally treated with vehicle (0.
Ang II-induced contraction is impaired in the aortas of renovascular hypertensive animal model.
Vasc Biol
January 2024
Department of Physics and Chemistry, Faculty of Pharmaceutical Sciences of Ribeirão Preto - University of São Paulo - USP, Brazil.
Abstract: Renin-angiotensin system plays a critical role in blood pressure control, and the abnormal activation of the AT1 receptor contributes to the development of renovascular hypertension. This study aimed to evaluate the underlying cellular signaling for AT1 receptor activation by Ang II and to compare this mechanism between aortas from 2K-1C and 2K rats. Effects of antagonists and inhibitors were investigated on Ang II-induced contractions in denuded or intact-endothelium aortas.
View Article and Find Full Text PDFInterventions for renal artery stenosis: Appraisal of novel physiological insights and procedural techniques to improve clinical outcome.
Catheter Cardiovasc Interv
August 2024
Heart Center, University Hospital Gent, Gent, Belgium.
Article Synopsis
Comparative assessment of CacyBP/SIP, β-catenin and cannabinoid receptors in the adrenals of hypertensive rats.
J Cell Mol Med
May 2024
Department of Histology and Cytophysiology, Medical University of Bialystok, Bialystok, Poland.
Taking into account homeostatic disorders resulting from arterial hypertension and the key importance of CacyBP/SIP, β-catenin and endocannabinoids in the functioning of many organs, it was decided to assess the presence and distribution of CacyBP/SIP, β-catenin, CB1 and CB2 in the adrenal glands of hypertensive rats of various aetiology. The study was conducted on the adrenal glands of rats with spontaneous and renovascular hypertension. The expression of CacyBP/SIP, β-catenin, CB1 and CB2 was detected by immunohistochemistry and real-time PCR method.
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