Cluster of specified microRNAs in tissues and serum as biomarkers for early diagnosis of hepatocellular carcinoma.

Objective: Hepatocellular carcinoma (HCC) is a global public health concern that lacks efficient methods for early diagnosis. Accumulated evidence has revealed great potential using microRNAs (miRNAs) as noninvasive biomarkers in HCC detection.

Methods: Serum miRNAs (miR21, miR122, miR-214, miR15b, and let-7f) were detected in 75 patients with HCC and 80 healthy controls (HC).

High expression of NME1 correlates with progression and poor prognosis in patients of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is one of the most common malignancies that results from genes regulation via different pathways. NME/NM23 nucleoside diphosphate kinase 1 (NME1) is generally regarded as a metastasis suppressor, but its function in HCC is largely unknown. In our study, we explored the role of in HCC.