miR-125b suppresses the proliferation of hepatocellular carcinoma cells by targeting Sirtuin7.

Previous studies have shown that microRNAs are involved in many human cancers. However, the role of miR-125b in hepatocellular carcinoma (HCC) has not been fully understood. In our study, we detected the expression of miR-125b using Real-time quantitative-polymerase chain reaction (RT-PCR) and found that the expressions of miR-125b were significantly inhibited in HCC tissues and cell lines.

Tissue factor is strongly expressed in pericarcinomatous tissue in patients with laryngeal carcinoma.

Objective: This study aimed to understand the relationship between tissue factor (TF) and laryngeal carcinoma.

Methods: Differences in TF expression between pericarcinomatous and carcinomatous tissues were studied in patients with laryngeal carcinoma; the potential clinical significance of the observed differences is discussed. Immunohistochemical, western blot, and RT-PCR analyses were performed to assess the expression of TF at the protein and mRNA levels, and differences between pericarcinomatous and carcinomatous tissues in patients (n = 20) with laryngeal carcinoma were analyzed.

MiR-16 modulate temozolomide resistance by regulating BCL-2 in human glioma cells.

Temozolomide (TMZ) with radiotherapy is the current standard of care for newly diagnosed glioma. However, glioma patients who are treated with the drug often develop resistance to it and some other drugs. Recently studies have shown that microRNAs (miRNAs) play an important role in drug resistance.

Expression and significance of miR155 and vascular endothelial growth factor in placenta of rats with preeclampsia.

Objective: This study is to investigate the expression and significance of miR155 and vascular endothelial growth factor (VEGF) in placenta of preeclampsia (PE) model rats.

Methods: A total of 20 SD rats were randomly divided into normal pregnant group and PE model group. PE model was established by subcutaneous injection of L nitro arginine methyl ester continuously for 4 days with a dosage of 200 mg/Kg·d from the 13th day of pregnancy.

Association between X-ray repair cross-complementing group 1 gene polymorphisms and glioma risk: a systematic review and meta-analysis based on 22 case-control studies.

Objectives: Glioma is the most common central nervous system tumor. This systematic review and meta-analysis is aimed to systematically assess the association of XRCC1 polymorphisms with the risk of glioma.

Methods: Such databases as EMbase, PubMed, The Cochrane Library, the China National Knowledge Infrastructure (CNKI) platforms, VIP and WanFang were searched up to April 2015 to collect case-control studies of association between XRCC1 polymorphisms and glioma.

Down-regulation of neutrophil gelatinase-associated lipocalin in head and neck squamous cell carcinoma correlated with tumorigenesis, not with metastasis.

To examine the significance of the Neutrophil gelatinase-associated lipocalin (NGAL) in diagnosing head and neck squamous cell carcinoma (HNSCC) and predicting regional metastasis. We first used GEO dataset to analyze the NGAL gene expression in HNSCC. Then, we summarized the characteristics of patients retrospectively selected in clinic.

Clinical significance of dynamic monitoring by transcranial doppler ultrasound and intracranial pressure monitor after surgery of hypertensive intracerebral hemorrhage.

The aim of this study was to investigate the surgical method of hypertensive intracerebral hemorrhage (HIH) and how to control the postoperative blood pressure. 96 HIH patients were performed the craniotomic hematoma dissection (CHD) and the hematoma-cavity drilling drainage (HCDD), respectively. Meanwhile, the intracranial pressure and mean arterial pressure of each patient were continuously monitored for 7 days, the postoperative 1(st), 3(rd), 7(th) and 14(th)-day average flow velocities and pulsatility indexes of the bilateral middle cerebral arteries were monitored.

Puerarin inhibits proliferation and induces apoptosis in human glioblastoma cell lines.

Puerarin has been widely used in clinical treatment and experiment research and is considered to exert an anticancer effect recently. The present study investigated the anticancer activity of puerarin in U251 and U87 human glioblastoma cells. The cells were treated with puerarin at various concentrations for different times.

Association of hOGG1 Ser326Cys polymorphism with susceptibility to hepatocellular carcinoma.

Background: Since, the relationship between hOGG1 Ser326Cys polymorphism and HCC was inconsistent in the recent literatures. The present meta-analysis based on previous studies was to obtain precise estimation on the issue.

Methods: A computer search was carried out from PubMed, CBM and EMBASE databases.

Endovascular management of ruptured basilar superior cerebellar artery junction aneurysms: a series of three cases with review of literature.

Aneurysms located on the bailar superior cerebellar artery (SCA) junction are very rare. Endovascular coiling is a safe and feasible treatment option for these challenging cases regardless of the narrow operative field, their intimate relationship to perforating vessels and cranial nerves, which results in high morbidity and mortality rates during clipping. From Jan.

Renal cell carcinoma risk is associated with the interactions of APOE, VHL and MTHFR gene polymorphisms.

Objective: The study was designed to explore the association of renal cell carcinoma (RCC) with VHL (rs779805), MTHFR (rs1801133) and APOE (rs8106822 and rs405509) polymorphisms, investigate the interactions among the single nucleotide polymorphisms (SNPs), and explore roles of the interactions in the pathogenesis of RCC in Chinese Han population.

Methods: 81 RCC patients and 80 healthy controls were included in the study. Polymerase chain reaction (PCR) and direct sequencing methods were used in the analysis on the genotypes of APOE, VHL and MTHFR gene polymorphisms.

DIM attenuates TGF-β1-induced myofibroblast differentiation in neonatal rat cardiac fibroblasts.

3,3'-Diindolylmethane (DIM) is a natural component of cruciferous plants. Previous studies have shown that DIM has multiple physiological effects including anti-angiogenic, anti-inflammatory and anti-cancer effect. However, little is known about the role of DIM on myofibroblast differentiation and extracellular matrix (ECM) production.

E6/E7 oncoproteins of high risk HPV-16 upregulate MT1-MMP, MMP-2 and MMP-9 and promote the migration of cervical cancer cells.

Background: E6 and E7 of high risk human papillomavirus 16 (HPV16) were reported to correlate with the cervical cancer (CC). And the presence of matrix metalloproteinases (MMPs) has also been indicated to be associated with CC.

Methods: The present study investigated the expression of MMPs (MT1-MMP, MMP-2 and MMP-9) in CC cells with HPV16-E6/E7 oncoprotein(s) negative or positive, and then determined the regulation of HPV16-E6/E7 oncoproteins on the expression of MMPs (MT1-MMP, MMP-2 and MMP-9) and the migration of cervical cancer Caski and SiHa cells with RNAi technology.

LRIG1 enhances the radiosensitivity of radioresistant human glioblastoma U251 cells via attenuation of the EGFR/Akt signaling pathway.

The radiotherapy as a local and regional modality is widely applied in treatment of glioma, but most glioblastomas are commonly resistant to irradiation treatment. It remains challengeable to seek out efficient strategies to conquer the resistance of human glioblastoma cells to radiotherapy. Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1) is a newly discovered tumor suppressor which involved in regulation of chemosensitivity in various human cancer cells.

Lack of association between CD14-159 C/T polymorphism and acute pancreatitis: a meta-analysis.

The CD14-159 C/T polymorphism has been implicated in susceptibility to acute pancreatitis (AP), but the results were inconclusive. The present meta-analysis aimed to explore the correlation between CD14-159 C/T polymorphism and AP risk. All eligible case-control studies published up to November 10th, 2014 were identified by searching PubMed, Web of Science, CNKI, and WanFang databases.

Effects of angiotensin-converting enzyme inhibition and bradykinin peptides in rats with myocardial infarction.

Background And Objective: Angiotensin-converting enzyme (ACE) inhibitors have been reported to decrease myocardial remodeling and faciliate cardiac function improvement in the setting myocardial infarction by affecting bradykinin. The purpose of this study was to evaluate the combination effects of perindopril and bradykinin (BK) in rats with myocardial infarction.

Methods: Wistar Rats underwent to left anterior descending (LAD) coronary artery ligation were allocated into MI group (n=6); Perindopril group (n=7); Perindopril+BK group (n=7).

Catalpol protects mice against renal ischemia/reperfusion injury via suppressing PI3K/Akt-eNOS signaling and inflammation.

Renal ischemia/reperfusion-injury (IRI) is a common disease in clinic, which is also the most common cause of acute kidney failure. Previous investigations has illustrated that catalpol has neuroprotective, anti-inflammatory, and anti-hepatitis virus effects. This study was designed to investigate the protective effect of catalpol on renal IRI mice through suppressing phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt)-endothelial nitric oxide synthase (eNOS) and against inflammation, and the possible underlying mechanism.

MICA polymorphisms and cancer risk: a meta-analysis.

The major histocompatibility complex class I chain-related gene A transmembrane (MICA-TM) polymorphism has been implicated in susceptibility to cancer. However, the results are inconsistent. The aim of this meta-analysis is to evaluate the association between the MICA-TM polymorphisms and cancer risk.

MicroRNA-19a promotes glioma cell growth by repressing LRIG1.

Growing evidence indicates that deregulation of miRNAs contributes to the development of glioma. In present study, we found that the level of miRNA-19a was significantly elevated in glioma tissues and cell lines. Moreover, down-regulation of miRNA-19a dramatically repressed glioma cell growth in vitro and in vivo.

Atorvastatin ameliorates myocardial ischemia/reperfusion injury through attenuation of endoplasmic reticulum stress-induced apoptosis.

Endoplasmic reticulum stress (ERS) is known to play an important role in mediating myocardial ischemic/reperfusion (I/R) injury. Some previous studies have shown that atorvastatin alleviates myocardial I/R injury in animal models, but whether attenuation of ERS-induced apoptosis contributes to this effect remains to be elucidated. Therefore, in this study, we sought to investigate the modulatory effect of atorvastatin on myocardial I/R-induced ERS in rats.

XPG Asp1104His polymorphism and gastrointestinal cancers risk: a meta-analysis.

Several studies have reported the association between the Asp1104His polymorphism in xeroderma pigmentosum group G (XPG) gene and risk of gastrointestinal cancers. However, the results are inconsistent. This meta-analysis was performed to assess the association between XPG Asp1104His polymorphism and gastrointestinal cancers risk.

Risk association of meningiomas with MTHFR C677T and GSTs polymorphisms: a meta-analysis.

Previous studies have shown that the single nucleotide polymorphisms (SNPs) in Methylenetetrahydrofolate reductase (MTHFR) and Glutathione S-transferases (GSTs, including GSTM1, GSTT1) genes play an important role in determining the response of an individual to environmental pathogenesis and significantly relate to incidences of various human tumors, including brain tumors. However, these genes' polymorphisms on meningioma risk remains poorly understood. The relevant inferences from previous studies are hindered by their limited statistical power and conflicting results.

ATPase may play a critical role in disturbance of energy metabolism in congestive heart failure rats.

Objective: This study aims to explore the expression and significance of ATPase in myocardium of congestive heart failure induced by pressure overload in rats.

Methods: Male SD rats were divided into 3 groups randomly: Control group (C group), coarctation of abdominal aorta 15 weeks group (A group) and sham operation group (SH group). The hemodynamics parameters were measured.

Listeria infection in Chinese pregnant women and neonates from Shandong.

Objective: This study aims to investigate the characters of pregnant women and neonates with listeria monocytogenes infections (L. monocytogenes) in Shandong of China.

Method: Pregnant women with premature delivery or prenatal fever were recruited in 2013.

Distinct patterns of ALDH1A1 expression predict metastasis and poor outcome of colorectal carcinoma.

Purpose: Aldehyde dehydrogenase 1A1 (ALDH1A1) has been proposed as a candidate biomarker for colorectal carcinoma (CRC). However, the heterogeneity of its expression makes it difficult to predict the outcome of CRC. The aim of this study was to evaluate the diagnostic and prognostic value of this molecule in CRC.