Threat Appraisal and Pediatric Anxiety: Proof of Concept of a Latent Variable Approach.

Elevated threat appraisal is a postulated neurodevelopmental mechanism of anxiety disorders. However, laboratory-assessed threat appraisals are task-specific and subject to measurement error. We utilized latent variable analysis to integrate youth's self-reported threat appraisals across different experimental tasks; we next examined associations with pediatric anxiety as well as behavioral and psychophysiological task indices.

Intranasal Oxytocin Combined With Social Skills Training for Schizophrenia: An Add-on Randomized Controlled Trial.

Some but not other studies on oxytocin for schizophrenia, particularly those using a higher dose, indicate that oxytocin improves negative symptoms of schizophrenia. We performed an add-on randomized controlled trial to examine the effect of high-dose oxytocin, social skills training, and their combination in the treatment of negative symptoms and social dysfunction in schizophrenia. Fifty-one subjects with schizophrenia were randomized, employing a two-by-two design: intranasal oxytocin (24 IU X3/day) or placebo, and social skills training or supportive psychotherapy, for 3 weeks.

Differential Expression Analysis of Cutaneous Squamous Cell Carcinoma and Basal Cell Carcinoma Proteomic Profiles Sampled with Electroporation-Based Biopsy.

Clinical misdiagnosis between cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC) affects treatment plans. We report a tissue sampling approach with molecular biopsy using electroporation. This method, coined electroporation-based biopsy (e-biopsy), enables nondestructive nonthermal permeabilization of cells in the skin for vacuum-assisted extraction of biomolecules.

Detecting significant expression patterns in single-cell and spatial transcriptomics with a flexible computational approach.

Gene expression data holds the potential to shed light on multiple biological processes at once. However, data analysis methods for single cell sequencing mostly focus on finding cell clusters or the principal progression line of the data. Data analysis for spatial transcriptomics mostly addresses clustering and finding spatially variable genes.

The post ICU trajectory: Post acute and post ICU nutritional care.

ICU survivors are growing but a persistent physical and mental disability may occur. The patients discharged from ICU are frequently malnourished and their medical nutritional support is impaired by oral intake limitation due to respiratory support such as non invasive ventilation or high flow nasal cannula oxygen therapy, dysphagia and difficulties to determine energy and protein targets. ICU acquired weakness must be recognized and could be minimized by better energy intake determined by indirect calorimetry, optimal protein intake and physical activity.

Behavioral and Psychosocial Dynamics of Engagement: The Digital Divide in Artificial Intelligence [AI]-Driven Sports Podcasts.

The digital divide, particularly within the context of Artificial Intelligence (AI) sport podcasts, presents significant behavioral and psychosocial challenges for student engagement. This study examines the disparities in access to and proficiency with Information Communication Technologies (ICTs) across different demographic groups, focusing on gender, age, and religious level. The advent of the commercial web has heightened the significance of these divides, as the first-level digital divide concerns access to the internet, while the second-level digital divide pertains to the ability to use technology proficiently.

Effectiveness of ex ante honesty oaths in reducing dishonesty depends on content.

Dishonest behaviours such as tax evasion impose significant societal costs. Ex ante honesty oaths-commitments to honesty before action-have been proposed as interventions to counteract dishonest behaviour, but the heterogeneity in findings across operationalizations calls their effectiveness into question. We tested 21 honesty oaths (including a baseline oath)-proposed, evaluated and selected by 44 expert researchers-and a no-oath condition in a megastudy involving 21,506 UK and US participants from Prolific.

An Ethical Perspective on the Democratization of Mental Health With Generative AI.

Knowledge has become more open and accessible to a large audience with the "democratization of information" facilitated by technology. This paper provides a sociohistorical perspective for the theme issue "Responsible Design, Integration, and Use of Generative AI in Mental Health." It evaluates ethical considerations in using generative artificial intelligence (GenAI) for the democratization of mental health knowledge and practice.

Deep genetic substructure within bonobos.

Establishing the genetic and geographic structure of populations is fundamental, both to understand their evolutionary past and preserve their future. Nevertheless, the patterns of genetic population structure are unknown for most endangered species. This is the case for bonobos (Pan paniscus), which, together with chimpanzees (Pan troglodytes), are humans' closest living relatives.

A narrative on the neurobiological roots of attachment-system functioning.

Attachment theory is one of the most comprehensive frameworks in social and developmental psychology. It describes how selective, enduring emotional bonds between infants and their caregivers are formed and maintained throughout life. These attachment bonds exhibit distinct characteristics that are intimately tied to fundamental aspects of mammalian life, including pregnancy, birth, lactation, and infant brain development.

Texture and visual memory span capacities are dissociable.

Experiencing and remembering objects using the sense of touch is an important aspect of our interactions with our environment, but the cognitive processes of long-term tactile memory for surface textures have not previously been studied. We administered a novel tactile texture memory span task, which required participants to identify new textures among a constantly increasing set of previously experienced stimuli. Performance on that task was compared to a span task employing novel visual objects.

Cross-Cultural Comparison of the Strengths and Difficulties Self-Report Questionnaire in 12 Asian and European Countries.

Objective: The self-report Strengths and Difficulties Questionnaire (SDQ) is widely used globally; hence, the validity of the intergroup comparisons is essential. This study examined the structure of the self-report SDQ in a large multinational adolescent sample, tested its measurement invariance across genders and countries, and compared youth mental health in 12 European and Asian countries.

Method: This study is part of the Eurasian Child Mental Health Study (EACMHS), a cross-cultural research study of child and adolescent well-being and mental health in 12 Asian and European countries.

Using mobile eye-tracking to evaluate gaze behavior during a speech in pediatric anxiety disorders.

Background: Altered gaze in social settings is a hallmark of social anxiety; however, little research directly examines gaze in anxiety-provoking contexts among youth with anxiety disorders, limiting mechanistic insight into pediatric anxiety. The present study leveraged mobile eye-tracking technology to examine gaze behavior during a naturalistic stressor in a clinical developmental sample.

Methods: Sixty-one youth (ages 8-17 years; 28 with anxiety disorders, 33 non-anxious controls) completed a naturalistic social stress task (public speaking in front of a videotaped classroom audience) while wearing eye-tracking glasses.

Positivity as a moderator of the association between enacted stigma and mental health among lesbian, gay, and bisexual individuals.

In this study, we investigated the association between enacted stigma and adverse mental health outcomes in Israeli lesbian, gay, and bisexual (LGB) individuals. Additionally, we explored the moderating effect of positivity, namely the inclination to perceive oneself, one's life, and one's future in a generally positive outlook, in this association. For this purpose, we surveyed 520 cisgender LGB Israelis ( = 33.

Sensitive infant care tunes a frontotemporal interbrain network in adolescence.

Caregiving plays a critical role in children's cognitive, emotional, and psychological well-being. In the current longitudinal study, we investigated the enduring effects of early maternal behavior on processes of interbrain synchrony in adolescence. Mother-infant naturalistic interactions were filmed when infants were 3-4 months old and interactions were coded for maternal sensitivity and intrusiveness with the Coding Interactive Behavior Manual.

Telerobotic Intergroup Contact: Acceptance and Preferences in Israel and Palestine.

We explore telerobotics as a novel form of intergroup communication. In this form, remotely operated robots facilitate embodied and situated intergroup contact between groups in conflict over long distances, potentially reducing prejudice and promoting positive social change. Based on previous conceptual frameworks and design hypotheses, we conducted a survey on the acceptance and preferences of the telerobotic medium in Israel and Palestine.