6,205 results match your criteria: "Rehabilitation Management of Neuromuscular Disease"

High Body Mass Index Disrupts the Homeostatic Effects of Pain Inhibitory Control in the Symptomatology of Patients With Fibromyalgia.

J Pain

December 2024

Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

Article Synopsis
  • This study looks at how body mass index (BMI) impacts the relationship between sensory pain testing and clinical symptoms in fibromyalgia syndrome (FMS).
  • It finds that higher BMI, particularly being overweight or obese, affects how pain response mechanisms relate to symptoms like depression, and this influence is not seen in normal-weight individuals.
  • The research emphasizes the importance of considering BMI in FMS treatment strategies, suggesting that high BMI disrupts the body’s ability to manage pain, which can worsen overall health outcomes.
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  • The growth of rare disease therapeutics is leading to various innovative treatment options, including orphan medicinal products, medical devices, rehabilitative therapies, and digital therapeutics, all addressing unique patient needs.
  • The paper discusses insights from the RE(ACT)-IRDiRC Conference 2023, focusing on orphan medical device development, the associated challenges, and the opportunities presented in this expanding field.
  • Examples of groundbreaking devices include an exoskeleton for Duchenne Muscular Dystrophy and a seizure-detecting EEG device, both emphasizing the importance of patient-centric design and the need for increased support in research for rare disease therapies.
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  • * Recent efforts to stop smoking haven't been put into action yet, and it’s important to see what could happen if smoking rates stay the same or improve.
  • * Researchers used models to predict health outcomes by 2050 based on different scenarios of smoking rates, showing that cutting smoking could greatly improve health and life expectancy.
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Background: Peripheral neuropathy is estimated to be prevalent in up to 12% of the population, increasing to 30% in older demographics. This makes peripheral neuropathy one of the most common neurological diseases in the United States.

Objectives: This retrospective study aims to report on the efficacy and safety of peripheral nerve stimulation (PNS) on the treatment of peripheral neuropathy in a commercial setting.

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Background: Spinal cord stimulation can be considered in PHN patients if conservative treatment is not effective. However, the long-term pain outcomes of temporary (7-14 days) spinal cord stimulation (tSCS) in refractory PHN patients with a course of more than 3 months have not been  documented.

Objectives: To investigate the efficacy of tSCS as a treatment for refractory PHN.

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Article Synopsis
  • * Out of 415 studies reviewed, only three met the criteria, revealing mixed results on HVLATs' effectiveness compared to sham treatments or other therapies, with no adverse events reported.
  • * Overall, the evidence regarding the efficacy of HVLATs for LSRS is considered "very low," indicating a need for more robust research to determine their actual benefits.
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Purpose: Management of cervical radicular pain is complex and may be resistant to conservative treatment. The primary aim of this study was to evaluate the efficacy of ultrasound-guided selective cervical nerve root pulsed radiofrequency (US-SCNR PRF) treatment in patients with radicular neck pain due to cervical disc herniation who did not respond to conservative treatment. The secondary aim was to determine the efficacy of the treatment in terms of functionality, neuropathic pain, and treatment-related adverse events.

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Current Treatment Methods for Charcot-Marie-Tooth Diseases.

Biomolecules

September 2024

Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610041, China.

Article Synopsis
  • - Charcot-Marie-Tooth (CMT) disease is the most common inherited neuromuscular disorder, characterized by a range of symptoms, genetic variations, and unpredictable progression, with recent advances in molecular genetics aiding in its understanding and classification.
  • - Despite ongoing research into potential treatments, there are currently no approved methods to fully cure CMT, and existing options like rehabilitation and surgery only help manage symptoms.
  • - The review focuses on the underlying causes of various CMT subtypes and explores promising therapies, particularly in gene therapy, with some approaches reaching clinical trial stages.
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The French Society of Pediatric Neurology and the FILNEMUS network created a working group on corticosteroid therapy in children with Duchenne muscular dystrophy in order to analyze the literature review and current French practices. The aim of this work was to produce guidelines regarding treatment initiation, pre-therapeutic interventions, choice between available compounds, and treatment monitoring (dosage, duration, and discontinuation). The treatment side effects and their management are also detailed: osteoporosis, endocrinological anomaly (growth delay, weight gain, pubertal delay), cataract, arterial hypertension, behavioral disorders, management of immunosuppression and vaccines, and management of gastrointestinal and metabolic complications.

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  • The objective of this study was to review available rehabilitation strategies for cauda equina syndrome (CES), a serious condition that can lead to long-term disability.
  • The researchers conducted a scoping review, examining various sources to find relevant studies on treatment and rehabilitation methods for CES.
  • They identified eight studies but noted inconsistencies in outcomes, poor study quality, and a lack of solid conclusions, highlighting the need for better research to inform rehabilitation practices after CES surgery.
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Objective: Chemotherapy-induced neuropathy (CIN) significantly impacts cancer patients, leading to functional disability, diminished quality of life, and increased healthcare costs amid the ongoing opioid crisis. Auricular point acupressure (APA), a non-invasive and non-pharmacological alternative, has shown potential for alleviating the pain, numbness, and tingling associated with CIN. This study aims to assess the efficacy of APA for CIN symptoms and physical function and to examine the mechanisms underlying APA's effects on CIN.

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Purpose: To describe the clinical outcomes beyond pain relief of high-frequency spinal cord stimulation at 10 kHz (10 kHz SCS) in a patient with cervical myelopathy and drug-resistant chronic neuropathic pain with spastic tetraparesis.

Methods: A patient with C3-C6 myelomalacia and spastic tetraparesis previously treated with decompressive laminectomy underwent implantation of 10 kHz SCS for pain management through a trial procedure followed by permanent implantation. Due to the presence of epidural fibrotic scar tissue in the area of the previous C3-C6 laminectomy, the leads could not be implanted at the cervical level; therefore, the leads were positioned at the thoracic level.

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Article Synopsis
  • China faces a significant challenge with postherpetic neuralgia, necessitating effective new treatment options that minimize neurotoxic effects compared to current calcium channel ligands.
  • The study aimed to evaluate the efficacy and safety of crisugabalin, a new oral medication, involving a randomized clinical trial across 48 care centers in China, which included a 12-week treatment phase and a subsequent 14-week extension phase.
  • Results showed improvement in pain relief for patients taking crisugabalin, particularly at the 40 mg and 80 mg doses, highlighting its potential as a more effective treatment for managing postherpetic neuralgia compared to a placebo.
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Velocity-Based-Training Frequency Impacts Changes in Muscle Morphology, Neuromuscular Performance, and Functional Capability in Persons With Parkinson's Disease.

J Strength Cond Res

January 2025

Laboratory of Neuromuscular Research and Active Aging, Department of Kinesiology and Sports Sciences, University of Miami, Coral Gables, Florida.

Calaway, C, Walls, K, Levitt, H, Caplan, J, Mann, B, Martinez, K, Gastaldo, R, Haq, I, and Signorile, JF. Velocity-based-training frequency impacts changes in muscle morphology, neuromuscular performance, and functional capability in persons with Parkinson's disease. J Strength Cond Res 39(1): 99-106, 2025-Velocity-based training (VBT) positively impacts muscle morphology and performance in persons with Parkinson's disease (PD); however, optimal training frequencies for VBT in patients with PD remain undetermined.

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Profiles of disease progression and predictors of mortality in Colombian patients with amyotrophic lateral sclerosis: a comprehensive longitudinal study.

Amyotroph Lateral Scler Frontotemporal Degener

September 2024

Inserm U955, Institut Mondor de Recherche Biomédicale, NeuroPsychologie Interventionnelle, Créteil, France.

Article Synopsis
  • The study evaluated the effectiveness of the ALS Functional Rating Scale-Revised (ALSFRS-R) in predicting mortality and understanding disease progression in ALS patients in Colombia, analyzing data from 528 patients over 14 years.
  • Results showed that a one-point increase in the ALSFRS-R score significantly increased the risk of mortality, and initial assessments provided more reliable predictions than scores from multiple evaluations.
  • The research identified three different disease progression patterns (slow, intermediate, and rapid), highlighting the need for tailored treatment strategies based on individual patient trajectories.
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Background: Because of the unclear pathophysiology and the lack of consensus on the gold standard treatment of complex regional pain syndrome (CRPS), management requires a multidisciplinary approach, with the use of various treatment modalities. Nonetheless, no studies have ever been conducted to uncover the potential of mecobalamin as a treatment for CRPS type 1. Hence, the aim of this clinical trial was to evaluate the effects of mecobalamin on the functional outcomes of patients with CRPS type 1 of the foot and ankle, the total amount of pregabalin ingested, and the duration of pregabalin use in each patient.

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» Gunshot injuries to the upper extremity (UE) have high likelihood for causing peripheral nerve injury secondary to the high density of vital structures. Roughly one-fourth of patients sustaining a gunshot wound (GSW) to the UE incur a nerve injury. Of these nerve injuries, just over half are neurapraxic.

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  • Researchers studied strokes from 1990 to 2021 to understand how many people get them and how they are affected around the world.
  • In 2021, strokes caused about 7.3 million deaths and were a major cause of health problems, especially in specific regions like Southeast Asia and Oceania.
  • There are differences in stroke risks based on where people live and their age, and some areas actually saw more strokes happening since 2015.
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Background: Duchenne muscular dystrophy (DMD) is an incurable neuromuscular disease leading to progressive skeletal muscle weakness and fatigue. Cell transplantation in murine models has shown promise in supplementing the lack of the dystrophin protein in DMD muscles. However, the establishment of novel, long-term, relevant methods is needed to assess its efficiency on the DMD motor function.

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Limb-girdle muscular dystrophy in pregnancy: a narrative review.

Arch Gynecol Obstet

November 2024

Bangalore Medical College and Research Institute, K.R Road, Bangalore, Karnataka, 560002, India.

Article Synopsis
  • Limb-girdle muscular dystrophy (LGMD) presents specific pregnancy challenges for women, highlighting the importance of personalized care and management strategies throughout the process.
  • Preconception counseling, thorough health assessments, and collaborations between specialists and obstetricians are vital for monitoring both maternal and fetal health during pregnancy.
  • Postpartum care should focus on pain management, mobility support, and emotional well-being, along with tailored assistance with breastfeeding to address muscle weakness issues.
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Article Synopsis
  • - Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder primarily causing progressive muscle weakness, treated mainly with glucocorticoids and physical therapy.
  • - Joint hypermobility can occur alone or in connection with conditions like Ehlers-Danlos syndrome, which may lead to cardiovascular issues, while osteogenesis imperfecta involves fragile bones prone to fractures.
  • - Down syndrome (trisomy 21) is the most common chromosomal abnormality, and while routine imaging for atlantoaxial instability isn't recommended in asymptomatic children, careful evaluation is necessary for sports participation; achondroplasia, resulting in disproportionate short stature and other skeletal features, requires education for safe handling.
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Single center experience with hourglass-like constriction neuropathy of suprascapular nerve.

Muscle Nerve

November 2024

Department of Physical and Rehabilitation Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Article Synopsis
  • * A retrospective review identified 14 patients with HGC of the SSN, with MRI indicating constriction primarily between the nerve's origin and the suprascapular notch, and most patients receiving non-operative treatment.
  • * Findings suggest that conservative management is often effective, with significant recovery noted in the majority of patients after at least 6 months, indicating that immediate invasive treatment may not be necessary.
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Herpes zoster (HZ) is typically characterized by a burning, stabbing pain, hyperalgesia, and allodynia. In some patients, despite the lesions resolving, the pain persists and becomes chronic. If the pain continues for more than 6 months after the onset of the pain phase, this condition is called postherpetic neuralgia (PHN).

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