455 results match your criteria: "Rehabilitation Center for Persons with Disabilities[Affiliation]"

A Japanese national representative survey-the comprehensive survey of living conditions (CSLC)-included the Washington Group Short Set (WGSS) in 2022. This study aimed to characterize the WGSS in comparison to an existing disability measure (EDM), regarding the difference between disability prevalence defined by these two measures and the factors attributable to disagreements between them. A cross-sectional analysis using secondary data from the CSLC ( = 32,212) was conducted.

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Aim: This study aims to investigate the impact of aging on brain volume among community residents in Japan, focusing on trends over time and specific brain structures.

Methods: We analyzed data from the fourth survey (2015-2016) of the Research on Osteoarthritis/Osteoporosis Against Disability project, encompassing 2146 community residents from Japan's mountainous and coastal regions. A total of 1755 participants (81.

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Helicobacter pylori-Related Chronic Gastritis as a Risk Factor for Lower Bone Mineral Density.

Calcif Tissue Int

January 2025

Department of Gastroenterology, School of Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama, Wakayama, 641-0012, Japan.

We evaluated the role of Helicobacter pylori (H. pylori)-related chronic gastritis in the development of osteoporosis in a population-based study. A total of 1690 subjects in the cohort of the Research on Osteoarthritis/ osteoporosis Against Disability (ROAD) were investigated, and the association between gastritis and osteoporosis was evaluated by the presence of serologically assessed H.

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Impact of microgravity and lunar gravity on murine skeletal and immune systems during space travel.

Sci Rep

November 2024

Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

Article Synopsis
  • Long-duration spaceflight can stress the skeletal and immune systems, but the specific response mechanisms are still not fully understood.
  • A study with mice on the ISS evaluated how different gravitational conditions (microgravity, lunar gravity, and Earth gravity) affected their bone, thymus, and spleen over 25-35 days.
  • Results showed that while bone density loss in microgravity was mostly restored in Earth gravity, lunar gravity only offered partial recovery; microgravity also caused thymus shrinkage, partially reversible by both lunar and Earth gravity but with ongoing gene expression issues.
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Cognitive models of reading assume that speech production occurs after visual and phonological processing of written words. This traditional view is at odds with more recent magnetoencephalography studies showing that the left posterior inferior frontal cortex (pIFC) classically associated with spoken production responds to print at 100-150 ms after word-onset, almost simultaneously with posterior brain regions for visual and phonological processing. Yet the theoretical significance of this fast neural response remains open to date.

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The role of the extended amygdala and amygdala in mediating emotion and inhibitory control in native language versus second language processing is currently not well understood. The current study examined activity in the extended amygdala and amygdala when twelve healthy young adults were exposed to emotional-linguistic stimuli in either their native language (i.e.

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Phonological knowledge plays a pivotal role in many aspects of language processing, but it remains controversial whether it is required for writing. In the present study, we examined the issue by focusing on written production in an opaque logographic script (kanji) with highly irregular pronunciation rules, which allowed for a rigorous test of whether or not phonology contributes to writing. Using a phonological priming paradigm in two experiments, we measured response latency while participants orally named target pictures or wrote down their names in kanji.

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Intravenous Infusion of Autologous Mesenchymal Stem Cells Expanded in Auto Serum for Chronic Spinal Cord Injury Patients: A Case Series.

J Clin Med

October 2024

Department of Neural Regenerative Medicine, Institute of Regenerative Medicine, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.

Article Synopsis
  • * Seven patients received autologous MSCs without any serious side effects, showing no tumors or neurological decline throughout the process.
  • * Notable functional improvements and enhanced quality of life were reported 90 and 180 days after the infusion, indicating that this treatment could be beneficial for chronic SCI, though further large-scale studies are required for conclusive results.
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  • * This study explored how brain-to-muscle and brain-to-brain connectivity changes during standing and postural sway using electroencephalography (EEG) and electromyography (EMG) in various standing positions.
  • * Results showed enhanced muscle connectivity at peak sway in specific frequency bands and identified distinct patterns of brain connectivity that support posture control, particularly under conditions requiring more balance, like narrow-base standing.
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An asymmetric windswept posture is often seen in children with severe cerebral palsy (CP). However, it is still unclear how long children with CP remain in the windswept posture in daily life. Thus, we developed a triple-accelerometer system for detecting windswept posture.

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People with higher systemizing traits have wider right hands.

Front Psychiatry

September 2024

Developmental Disorders Section, Department of Rehabilitation for Brain Functions, Research Institute of National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Saitama, Japan.

Introduction: Various genetic mutations have been implicated in autism spectrum disorder (ASD). Some candidate genes for ASD are known to be related to signal transduction and may be involved in hand development as well as neurodevelopment. Therefore, although subtle, anatomical variations in hand configurations may be observed in individuals with ASD.

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Ten-Year Incidence of Sarcopenia in a Population-Based Cohort: Results from the Research on Osteoarthritis/Osteoporosis Against Disability Study.

J Am Med Dir Assoc

November 2024

Department of Preventive Medicine for Locomotive Organ Disorders, 22nd Century Medical & Research Center, Faculty of Medicine, University of Tokyo, Tokyo, Japan.

Objectives: To investigate the prevalence and incidence rates of sarcopenia in Japanese community-dwelling people according to the criteria of the Asian Working Group for Sarcopenia 2019 recommendations, using a large-scale population-based cohort over a 10-year follow-up period.

Design: Prospective cohort study.

Setting And Participants: This study was conducted using data from the Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study.

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Congenital insensitivity to pain with anhidrosis is an extremely rare disorder characterized by congenital generalized loss of pain and thermal sensation, decreased sweating, intellectual disability, and self-mutilating behavior. Skeletal complications can develop even after minor trauma or an unknown cause, and management is difficult and sometimes unsuccessful, leading to the development of Charcot joints. We report 3 patients whose hip instability was treated with a hip action brace (HAB) that allowed for free abduction but prevented adduction.

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Article Synopsis
  • Individuals with thalidomide embryopathy, now around 60 years old, have been coping with physical challenges due to limb development issues and experience secondary problems like pain.
  • Previous studies on their skeletal issues through imaging have mainly focused on younger individuals, with limited research on older adults.
  • This study used advanced imaging techniques to analyze the skeletons of five older individuals with thalidomide embryopathy, revealing issues such as joint dislocation, osteoarthritis, and abnormal bone development that likely contribute to their upper limb pain.
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Article Synopsis
  • The study aimed to identify factors linked to locomotive syndrome (LS) using medical questionnaires and machine learning techniques.
  • A total of 1,575 participants underwent LS risk tests, and after data cleaning, 331 questionnaire items were analyzed to determine their association with LS through advanced statistical methods.
  • Nine key factors, especially age and back pain during walking, were identified as strongly correlated with LS, showing better predictive performance compared to existing assessment tools.
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Researchers have been focusing on perceptual characteristics of autism spectrum disorder (ASD) in terms of sensory hyperreactivity. Previously, we demonstrated that temporal resolution, which is the accuracy to differentiate the order of two successive vibrotactile stimuli, is associated with the severity of sensory hyperreactivity. We currently examined whether an increase in the perceptual intensity of a tactile stimulus, despite its short duration, is derived from high temporal resolution and high frequency of sensory temporal summation.

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Falls in older individuals are a serious health issue in super-aged societies. The stepping reaction is an important postural strategy for preventing falls. This study aimed to reveal the characteristics of lateral stepping in response to mechanical disturbance by means of an analysis of the hip joint kinematics in the stepping leg and head stability during crossover steps.

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Effects of focal cortical cooling on somatosensory evoked potentials in rats.

Brain Res

October 2024

Department of Information Technology and Human Factors, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan; Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba Japan. Electronic address:

Although the focal brain cooling technique is widely used to examine brain function, the effects of cortical temperature at various levels on sensory information processing and neural mechanisms remain underexplored. To elucidate the mechanisms of temperature modulation in somatosensory processing, this study aimed to examine how P1 and N1 deflections of somatosensory evoked potentials (SEPs) depend on cortical temperature and how excitatory and inhibitory inputs contribute to this temperature dependency. SEPs were generated through electrical stimulation of the contralateral forepaw in anesthetized rats.

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Article Synopsis
  • This study focuses on the incidence and prevalence of stuttering in 3-year-old children in Japan, as few studies have examined this disorder in the country.
  • A questionnaire was used on 2,055 children to screen for stuttering, with positive cases confirmed through interviews and assessments by professionals.
  • The findings showed a prevalence of 6.5% for current stuttering and 8.9% when accounting for past stuttering, with higher risks associated with family history and concerns about the child's development.
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Individuals with acquired brain injury have reported subjective complaints of depth perception deficits, but few have undergone objective assessments to confirm these deficits. As a result, the literature currently lacks reports detailing the correlation between subjective depth perception deficits and objective stereoscopic vision deficits in individuals with acquired brain injury, particularly those cases that are characterized by a clearly defined lesion. To investigate this relationship, we recruited three individuals with acquired brain injury who experienced depth perception deficits and related difficulties in their daily lives.

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Background: We hypothesized that postural instability observed in individuals with Parkinson's disease (PD) can be classified as distinct subtypes based on comprehensive analyses of various evaluated parameters obtained from time-series of center of pressure (CoP) data during quiet standing. The aim of this study was to characterize the postural control patterns in PD patients by performing an exploratory factor analysis and subsequent cluster analysis using CoP time-series data during quiet standing.

Methods: 127 PD patients, 47 aged 65 years or older healthy older adults, and 71 healthy young adults participated in this study.

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Monitoring joystick operations in power wheelchairs (PWCs) is promising for investigating user-wheelchair interaction and providing quantitative measures to assess the user's driving performance. In this paper, an add-on measurement system, Power Wheelchair Maneuvering Logger (PWhML), is developed to provide an easy-to-implement and cost-effective solution for monitoring the user's joystick operations in PWCs. The proposed system uses two compact inertial measurement units (IMUs), which are respectively attached to the joystick and wheelchair armrest for movement sensing.

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Objective: This study aimed to characterize grasping behavior in static (weight-dependent modulation and stability of control) and dynamic (predictive control) aspects specifically focusing on the relative contribution of sensory and motor deficits to grip force control in patients with chronic stroke.

Methods: Twenty-four chronic stroke patients performed three manipulative tasks: five trials of 5-s grasp-lift-holding, 30-s static holding, and vertical dynamic/cyclic oscillation of holding the object.

Results: Exerted static grip force on the paretic side exhibited statistically greater than that on the non-paretic side.

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Ten-year trends in values of joint space width and osteophyte area of knee joints: Comparison of the baseline and fourth ROAD study surveys.

Osteoarthr Cartil Open

June 2024

Department of Preventive Medicine for Locomotive Organ Disorders, 22nd Century Medical & Research Center, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.

Article Synopsis
  • The study aimed to analyze the changes over ten years in the medial minimum joint space width (mJSW) and osteophyte area (OPA) of knee joints among Japanese adults using data from two independent cohorts.
  • Data was collected from nearly 3,000 participants in initial surveys between 2005-2007, followed by another survey with about 2,400 participants from 2015-2016, focusing on measuring mJSW and OPA using automated systems.
  • Results showed a significant increase in mJSW for both men and women over the ten years, suggesting a potential decrease in knee osteoarthritis incidence and progression, while OPA trends were less consistent.
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