Rising Prevalence of Multiple Sclerosis in Switzerland: Results from the Swiss Multiple Sclerosis Registry.

Introduction: Understanding the prevalence of multiple sclerosis (MS) provides information for healthcare planning and helps identify trends and patterns of disease occurrence. For Switzerland, the number of persons with MS (pwMS) was last estimated at approximately 15,000 in 2016. The study's objectives were to update estimates of MS prevalence and characterise the change in MS prevalence in Switzerland between 2016 and 2021, the last year with complete administrative data.

Influence of virtual reality and task complexity on digital health metrics assessing upper limb function.

Background: Technology-based assessments using 2D virtual reality (VR) environments and goal-directed instrumented tasks can deliver digital health metrics describing upper limb sensorimotor function that are expected to provide sensitive endpoints for clinical studies. Open questions remain about the influence of the VR environment and task complexity on such metrics and their clinimetric properties.

Methods: We aim to investigate the influence of VR and task complexity on the clinimetric properties of digital health metrics describing upper limb function.

Natural language processing analysis of the theories of people with multiple sclerosis about causes of their disease.

Background: While potential risk factors for multiple sclerosis (MS) have been extensively researched, it remains unclear how persons with MS theorize about their MS. Such theories may affect mental health and treatment adherence. Using natural language processing techniques, we investigated large-scale text data about theories that persons with MS have about the causes of their disease.

It's SNARC o' clock: manipulating the salience of the context in a conceptual replication of Bächtold et al.'s (1998) clockface study.

The Spatial-Numerical Association of Response Codes (SNARC) effect consists in faster left-/right-key responses to small/large numbers. (Bächtold et al., Neuropsychologia 36:731-735, 1998) reported the reversal of this effect after eliciting the context of a clockface-where small numbers are represented on the right and large numbers on the left.

White matter microstructure and executive functions in congenital heart disease from childhood to adulthood: A pooled case-control study.

Congenital heart disease (CHD) patients are at risk for alterations in the cerebral white matter microstructure (WMM) throughout development. It is unclear whether the extent of WMM alterations changes with age, especially during adolescence when the WMM undergoes rapid maturation. We investigated differences in WMM between patients with CHD and healthy controls from childhood until early adulthood in a pooled sample of children, adolescents, and young adults.

Goal-directed upper limb movement patterns and hand grip forces in multiple sclerosis.

Background: Upper limb disability in persons with Multiple Sclerosis (pwMS) leads to increased dependence on caregivers. To better understand upper limb disability, observer-based or time-based clinical assessments have been applied. However, these only poorly capture the behavioural aspects underlying goal-directed task performance.

Dissociation of motor control from motor awareness in awake sleepwalkers: An EEG study in virtual reality.

Recent behavioral evidence from a virtual reality (VR) study indicates that awake sleepwalkers show dissociation of motor control and motor awareness. This dissociation resembles the nocturnal disintegration of motor awareness and movement during episodes of sleepwalking. Here, we set out to examine the neural underpinnings of altered motor awareness in sleepwalkers by measuring EEG modulation during redirected walking in VR.

Real-world disease-modifying therapy usage in persons with relapsing-remitting multiple sclerosis: Cross-sectional data from the Swiss Multiple Sclerosis Registry.

Introduction: Several disease-modifying therapies (DMTs), covering a broad spectrum of mechanisms of action, have been approved by regulatory agencies for the treatment of relapsing-remitting multiple sclerosis (RRMS). However, only little is known about the current real-world treatment situation in Switzerland. Based on data from a diverse population of 668 persons with RRMS from the Swiss Multiple Sclerosis Registry (SMSR), the present study aims to fill this gap with a descriptive, cross-sectional approach.

Microstructural alterations of the corticospinal tract are associated with poor motor function in patients with severe congenital heart disease.

Congenital heart disease (CHD) patients are at risk for neurodevelopmental impairments, including altered motor function. However, little is known about the neuroanatomical correlates of persistent motor deficits in CHD. Thus, we examined the link between corticospinal tract (CST) microstructure and motor function in adolescent and adult CHD patients compared to healthy controls.

Uncertainty Promotes Neuroreductionism: A Behavioral Online Study on Folk Psychological Causal Inference from Neuroimaging Data.

Introduction: Increased efforts in neuroscience try to understand mental disorders as brain disorders. In the present study, we investigate how common a neuroreductionist inclination is among highly educated people. In particular, we shed light on implicit presuppositions of mental disorders little is known about in the public, exemplified here by the case of body integrity dysphoria (BID) that is considered a mental disorder for the first time in ICD-11.

Susceptibility of domain experts to color manipulation indicate a need for design principles in data visualization.

Color is key for the visual encoding of data, yet its use reportedly affects decision making in important ways. We examined the impact of various popular color schemes on experts' and lay peoples' map-based decisions in two, geography and neuroscience, scenarios, in an online visualization experiment. We found that changes in color mappings influence domain experts, especially neuroimaging experts, more in their decision-making than novices.

Altered white matter microstructure is related to cognition in adults with congenital heart disease.

Adults with congenital heart disease are at risk for persisting executive function deficits, which are known to affect academic achievement and quality of life. Alterations in white -matter microstructure are associated with cognitive impairments in adolescents with congenital heart disease. This study aimed to identify microstructural alterations potentially associated with executive function deficits in adults with congenital heart disease.

Publisher Correction: Gaze, visual, myoelectric, and inertial data of grasps for intelligent prosthetics.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Gaze, visual, myoelectric, and inertial data of grasps for intelligent prosthetics.

A hand amputation is a highly disabling event, having severe physical and psychological repercussions on a person's life. Despite extensive efforts devoted to restoring the missing functionality via dexterous myoelectric hand prostheses, natural and robust control usable in everyday life is still challenging. Novel techniques have been proposed to overcome the current limitations, among them the fusion of surface electromyography with other sources of contextual information.

Patients' experiences of unilateral spatial neglect between stroke onset and discharge from inpatient rehabilitation: a thematic analysis of qualitative interviews.

The purpose of this qualitative study was to explore how stroke patients with unilateral spatial neglect experience; (a) performance in activities of daily living; (b) alterations in bodily perceptions; and (c) personal hopes and expectations, looking at the period between stroke onset and discharge from inpatient rehabilitation. We conducted individual semi-structured interviews with 7 (5 men, 2 women, mean age 69 years) consecutively sampled participants. All interviews were transcribed verbatim and analyzed using thematic analysis.

Between-day reliability of three-dimensional motion analysis of the trunk: A comparison of marker based protocols.

Motion capture of the trunk using three-dimensional optoelectronic systems and skin markers placed on anatomical landmarks is prone to error due to marker placement, thus decreasing between-day reliability. The influence of these errors on angular output might be reduced by using an overdetermined number of markers and optimization algorithms, or by defining the neutral position using a reference trial. The purpose of this study was to quantify and compare the between-day reliability of trunk kinematics, when using these methods.

Validity and responsiveness of the German version of the Motor Activity Log for the assessment of self-perceived arm use in hemiplegia after stroke.

Background: Rehabilitation of patients after stroke requires valid and responsive assessments for arm and hand function to determine the effectiveness of rehabilitative interventions. The Motor Activity Log (MAL) aims to assess self-perceived arm and hand use after stroke. Its clinimetric properties are incomplete and contradictory.

Potential effectiveness of three different treatment approaches to improve minimal to moderate arm and hand function after stroke--a pilot randomized clinical trial.

Objective: To test a study design and explore the feasibility and potential effects of conventional neurological therapy, constraint induced therapy and therapeutic climbing to improve minimal to moderate arm and hand function in patients after a stroke.

Method: A pilot study with six-month follow-up in patients after stroke with minimal to moderate arm and hand function admitted for inpatient rehabilitation was performed. Participants were randomly allocated to one of three treatment approaches.

Increasing days at work using function-centered rehabilitation in nonacute nonspecific low back pain: a randomized controlled trial.

Objective: To evaluate the effect of function-centered compared with pain-centered inpatient rehabilitation in patients whose absence from work is due to chronic nonspecific low back pain (LBP).

Design: Single-blinded randomized controlled trial with follow-up assessments immediately after treatment and at 3 months.

Setting: Center for work rehabilitation in Switzerland.