The real-world outcomes of multiple myeloma patients treated with daratumumab.

Unlabelled: Most patients cannot be included in randomized clinical trials. We report real-world outcomes of all Danish patients with multiple myeloma (MM) treated with daratumumab-based regimens until 1 January 2019.

Methods: Information of 635 patients treated with daratumumab was collected retrospectively and included lines of therapy (LOT), hematologic responses according to the International Myeloma Working Group recommendations, time to next treatment (TNT) and the cause of discontinuation of treatment.

Outcome of treatment with carfilzomib before and after treatment with daratumumab in relapsed or refractory multiple myeloma patients.

Real world evidence is important since most patients cannot be included in randomized clinical trials (RCTs). In a nationwide, cohort of relapsed/refractory multiple myeloma patients treated with daratumumab (N = 635), we retrospective studied patients treated with carfilzomib (N = 251). Data were collected by audit of medical records.

Oncological outcomes of radical nephroureterectomy for upper urinary tract urothelial neoplasia in Denmark.

To report the oncological outcomes of radical nephroureterectomy for upper urinary tract urothelial neoplasia in a large study sample. This was a nationwide multicenter registry-based cohort study of all patients with upper urinary tract urothelial neoplasia in Denmark found to be eligible for nephroureterectomy between April 2004 and April 2017 ( = 1384). Primary endpoints were intravesical recurrence-free survival and overall survival.

Pantoprazole in ICU patients at risk for gastrointestinal bleeding-1-year mortality in the SUP-ICU trial.

Background: The long-term effects of stress ulcer prophylaxis with pantoprazole are unknown in ICU patients. We report 1-year mortality outcome in the Stress Ulcer Prophylaxis in the Intensive Care Unit (SUP-ICU) trial.

Methods: In the SUP-ICU trial, acutely admitted adult ICU patients at risk of gastrointestinal bleeding were randomised to intravenous pantoprazole 40 mg vs placebo (saline) once daily during their ICU stay.

Noise-Induced Hearing Loss - A Preventable Disease? Results of a 10-Year Longitudinal Study of Workers Exposed to Occupational Noise.

Aims: To survey current, Danish industrial noise levels and the use of hearing protection devices (HPD) over a 10-year period and to characterise the association between occupational noise and hearing threshold shift in the same period. Furthermore, the risk of hearing loss among the baseline and the follow-up populations according to first year of occupational noise exposure is evaluated.

Materials And Methods: In 2001-2003, we conducted a baseline survey of noise- and hearing-related disorders in 11 industries with suspected high noise levels.

Hyperbaric oxygen may only be optional in head and neck necrotizing fasciitis: a retrospective analysis of 43 cases and review of the literature.

Background: Necrotizing fasciitis in the head and neck (NF-HN) is a rare and potentially life-threatening condition. The use of hyperbaric oxygen therapy (HBOT) in the acute regimen is disputed and there is a lack of evidence of therapeutic effect. This study aims to describe a retrospective cohort of patients with NF-HN and investigate the use of HBOT and consequences thereof.

LAM study: Effects of lacosamide on behaviour and quality of life in patients with epilepsy.

Introduction: Psychiatric comorbidities are common in epileptic patients, and evaluating the impact of antiepileptic drugs on patients' moods is therefore essential. The aim of this study is to assess the effects of lacosamide on behaviour and quality of life in people with epilepsy.

Methods: We conducted a multicentre prospective observational study of poorly-controlled epileptic patients who received lacosamide as an adjuvant treatment.

Occupational noise exposure, psychosocial working conditions and the risk of tinnitus.

Purpose: The purpose of this study was to evaluate the influence of occupational noise (current and cumulative doses) and psychosocial work factors (psychological demands and decision latitude) on tinnitus occurrence among workers, using objective and non-self-reported exposure measures to prevent reporting bias.

Methods: In a cross-sectional study, we analyzed data from a Danish survey from 2009 to 2010 that included 534 workers from children day care units and 10 manufacturing trades. Associations between risk factors (current noise exposure, cumulative noise exposure and psychosocial working conditions) and tinnitus were analyzed with logistic regression.

[Penetrating injury of lower extremity caused by a heavy machine gun cartridge casing].

Penetrating injuries caused by cartridge casing are rarely described in the literature. This case report presents a 21-year-old male soldier with a lower extremity injury caused by a heavy machine gun cartridge casing. Physical examination revealed an entrance wound proximal and anterior of his right thigh and there were no exit wound identified.

[Lithium can be given to patients on haemodialysis treatment].

Lithium-induced nephropathy is a known complication of lithium treatment in bipolar disorder. Treatment with lithium should be discontinued, if there is evidence of lithium-induced nephropathy. However, lithium can be given to patients with end-stage-renal-disease on haemodialysis treatment, if there is no other way to control the bipolar disorder.

[High doses of aldosterone antagonist is a condition of sufficient blood pressure control in bilateral adrenal hyperplasia].

Primary aldosteronism occurs in 1-10% of hypertensive patients and is classified in adenomas or bilateral adrenal hyperplasia. Computed tomography (CT) or magnetic resonance imaging can be used to discriminate these subtypes and in guiding treatment selection. This case report describes a 65-year-old man with hypertension and hypokalaemia during 25 years.

[Urgent revascularisation can preserve renal function in a patient with severe hypertension because of renal artery stenosis].

We present a case of a 61-year-old woman with renal artery stenosis in a solitary functional kidney. The patient was admitted with recurrent severe hypertension, flash pulmonary oedema and acute kidney failure. She underwent surgical intervention, after which blood pressure and plasma creatinine level remained normal during a 11-year follow-up.

[Cowper's syringocele as cause of low urinary tract symptoms in a young man].

Cowper's syringocele (CS) is a very rare deformity of male urethra causing obstructive voiding symptoms. This case presents a 39-year-old man suffering from classical low urinary tract symptoms for five years, though without nocturia. The work-up showed normal prostate-specific antigen level, benign conditions by digital rectal examination, and normal-sized prostate on ultrasound.

Endoscopic dacryocystorhinostomy seems promising for lacrimal stenosis.

Introduction: Acquired nasolacrimal drainage obstruction (ANLDO) is a common ophthalmic problem with symptoms like epiphora and dacryocystitis. The standard surgery for ANLDO is dacrocystorhinostomy (DCR) in which the lacrimal sac is connected directly to the nose. There are two types of DCR, external (exDCR) and endonasal (enDCR).

[Pyomyositis caused by Streptococcus pneumoniae in a previously healthy 20-year-old man].

Pyomyositis is a bacterial infection of the skeletal muscle usually caused by Staphylococcus aureus. This case report presents a 20-year-old man with pyomyositis caused by Streptococcus pneumoniae. Pyomyositis is a rare but potentially critical disease, and early diagnosis, drainage and use of appropriate antibiotic therapy are essential to reduce morbidity and mortality.

[Subcutaneous emphysema after adenotonsillectomy].

Adenotonsillectomy is a commonly performed procedure in otorhinolaryngology departments. A rare complication is cervicofacial subcutaneous emphysema, that often resolves spontaneously, but may progress to obstruct upper airways or spread to the thorax causing pneumomediastinum or pneumothorax and impair cardiorespiratory function. A case of cervicofacial emphysema in a young woman undergoing routine adenotonsillectomy is presented, and possible mechanisms and treatment options are discussed.

[Complete ophthalmoplegia following outburst of herpes zoster].

An 86-year-old female presented with eye pain, complete ophthalmoplegia, a visual acuity of 1/60, vitritis, ptosis, displacement of the eye, and a partially dilated pupil unresponsive to light. A computed tomography of the cerebrum was normal. Herpes zoster ophthalmicus was suspected and treatment with i.

[Improved prognosis in light chain nephropathy due to multiple myeloma].

A 64 year-old woman with acute renal failure and cast nephropathy due to excessive production of lambda free light chains received chemotherapy (using bortezomib and dexamethason) and haemodialysis with a high cut off-filter. The concentration of free light chains was markedly reduced after a fortnight. Nine months after admission, the patient's kidney function had improved and dialysis was stopped.

[Primary hyperparathyroidism as a cause of chronic renal failure].

Nephrocalcinosis is a rare cause of chronic renal failure. We describe a 64 year-old man, who was admitted to hospital due to chronic renal failure. An ultrasound examination and a computed tomography of the kidneys showed bilateral, severe nephrocalcinosis.

Preoperative physical optimization in fast-track hip and knee arthroplasty.

Introduction: The aim of this study was to investigate if screening and optimization of risk patients combined with a motivational conversation is effective in reducing complications in patients scheduled for a fast-track hip and knee arthroplasty.

Material And Methods: We included 78 patients in the intervention group and 54 patients in a control group before the intervention. In the intervention group, all patients participated in a motivational conversation during which they were screened, and a nurse addressed all risk areas in patients at risk.

[Improved prognosis of cystinosis achieved by treatment with cysteamine and by kidney transplantation].

Cystinosis is a rare, autosomal recessive disease with cystine deposits in different tissues. First signs come from kidneys and eyes, but during progression of the disease other organs can also be affected. Previously, patients with cystinosis had a very poor prognosis, but it is now considerably improved due to new methods of treatment.

[Regression of severe periarticular calcifications during treatment with bisphosphonate in a dialysis patient].

Treatment with etidronate, 400 mg daily, induced total regression of severe, disabling periarticular calcifications during a treatment period of 42 months in a patient with chronic kidney disease on dialysis treatment. All symptoms disappeared. No adverse effects were recorded during the treatment.