25 results match your criteria: "Regional University Hospital Centre Tours[Affiliation]"
J Thromb Haemost
October 2024
National Institute of Health and Medical Research, National Research Institute for Agriculture, Food and Environment, Research Center for Cardiovascular and Nutrition, Faculty of Medicine, Aix Marseille University, Marseille, France; Reference Center on Constitutional Platelet Disorders, Biogenopole, University Hospital Center Timone, Public Assistance - Hospitals of Marseille, Marseille, France. Electronic address:
Background: Inherited platelet diseases are bleeding disorders characterized by either defects in platelet count or platelet function, the latter being less common and very heterogeneous. Numerous gene variants associated with abnormal receptors, granules, and signaling pathways have been reported. Despite significant advancements in our understanding, many patients still lack a precise diagnosis.
View Article and Find Full Text PDFClin Exp Rheumatol
November 2024
Department of Rheumatology, CHU and University of Montpellier, Phymedexp, Université de Montpellier, INSERM, CNRS, Montpellier, France.
J Neurointerv Surg
October 2024
Clinical Neurosciences, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada.
BMJ Support Palliat Care
June 2024
Medical Oncology Department, Regional University Hospital Centre Tours, Tours, Centre-Val de Loire, France
J Thromb Haemost
August 2024
Department of Haemostasis, Regional University Hospital Centre Tours, Tours, France; Institut National de la Santé et de la Recherche Médicale INSERM U1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, Université de Tours, Tours, France.
Background: Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a complication of adenoviral-based vaccine against SARS-CoV-2 due to prothrombotic immunoglobulin (Ig) G antibodies to platelet factor 4 (PF4) and may be difficult to distinguish from heparin-induced thrombocytopenia (HIT) in patients treated with heparin.
Objectives: We assessed the usefulness of competitive anti-PF4 enzyme immunoassays (EIAs) in this context.
Methods: The ability of F(ab')2 fragments of 1E12, 1C12, and 2E1, 3 monoclonal anti-PF4 antibodies, to inhibit the binding of human VITT or HIT antibodies to PF4 was evaluated using EIAs.
RMD Open
January 2024
Internal Medicine Department, Centre de Référence des Maladies Auto-immunes Systémiques Rares Du Nord et Nord-Ouest de France, Lille, France.
Background: Vascular phenotype is associated with a poor prognosis in systemic sclerosis (SSc). The identification of its risk factors could facilitate its early detection.
Objectives: To explore risk factors for a vascular phenotype of SSc, among them a history of pre-eclampsia.
Thromb Res
September 2023
Department of Pharmacy Practice and Science, University of Arizona R. Ken Coit College of Pharmacy, Tucson, AZ, USA; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:
Heparin-induced thrombocytopenia (HIT) is an antibody-mediated immune response against platelet factor 4 (PF4) bound to heparin anticoagulants. A priori identification of patients at-risk for HIT remains elusive and a number of risk factors have been identified, but these associations and their effect sizes have limited validation in large cohorts of suspected HIT patients. The aim of this study was to investigate existing anti-PF4/heparin antibody thresholds and model the relationship of demographic variables and anti-PF4/heparin antibody levels with functional assay positivity across multiple institutions in the absence of detailed clinical data.
View Article and Find Full Text PDFChildren (Basel)
August 2022
Neonatology Department, Regional University Hospital Centre Tours, 37000 Tours, France.
Magnesium ions are implicated in brain functioning. The disruption of brain metabolism subsequent to a perinatal hypoxic-ischaemic insult may be reflected by plasma magnesium. Infants at 36 weeks after birth or later with neonatal encephalopathy and who were admitted to our neonatal unit from 2011 to 2019 were retrospectively included.
View Article and Find Full Text PDFJ Thromb Haemost
November 2022
University of Tours, Tours, France.
Background: The diagnosis of heparin-induced thrombocytopenia (HIT) requires functional assays to demonstrate that platelet factor 4 (PF4)-specific antibodies activate platelets, typically when therapeutic heparin (H) concentrations are tested ("classical" pattern). Some HIT samples also activate platelets without heparin ("atypical" pattern), but with unclear clinical significance.
Objectives: We aimed to assess whether platelet activation pattern and some characteristics of PF4-specific antibodies were associated with the severity of HIT.
Clin Transplant
September 2022
Division of Transplantation, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland.
Introduction: The presence of median arcuate ligament (MAL) during orthotopic liver transplantation (OLT) may cause a significant reduction in the arterial hepatic flow. The aim of the present study is to investigate the impact of MAL on biliary complications in patients who underwent OLT.
Methods: We performed a retrospective case-control study among patients who underwent OLT in Geneva University Hospital between 2007 and 2017, depending on the presence or absence of MAL.
Ann Rheum Dis
January 2023
Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK
Blood Adv
July 2022
Department of Pharmacy Practice and Science, University of Arizona College of Pharmacy, Tucson, AZ.
BMJ Open
April 2022
Réanimation Médicale, University Hospital Centre Dijon, Dijon, France
Haematologica
October 2022
Regional University Hospital Centre Tours, Department of Hemostasis, Tours, France; University of Tours, EA7501 GICC, Tours.
In order to improve the safety of COVID-19 vaccines, there is an urgent need to unravel the pathogenesis of vaccineinduced immune thrombotic thrombocytopenia (VITT), a severe complication of recombinant adenoviral vector vaccines used to prevent COVID-19, and likely due to anti-platelet factor 4 (PF4) IgG antibodies. In this study, we demonstrated that 1E12, a chimeric anti-PF4 antibody with a human Fc fragment, fully mimics the effects of human VITT antibodies, as it activates platelets to a similar level in the presence of platelet factor 4 (PF4). Incubated with neutrophils, platelets and PF4, 1E12 also strongly induces NETosis, and in a microfluidic model of whole blood thrombosis, it triggers the formation of large platelet/leukocyte thrombi containing fibrin(ogen).
View Article and Find Full Text PDFBlood
July 2022
Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN.
Haematologica
May 2022
Dept. of Pathology and Molecular Medicine, and Dept. of Medicine, McMaster University, Hamilton, Ontario.
BMJ Open
September 2021
UMR 1246 Methods in Patients-Centered Outcomes and Health Research, INSERM, Nantes, France.
Objectives: Patients with severe spontaneous intracranial haemorrhages, managed in intensive care units, face ethical issues regarding the difficulty of anticipating their recovery. Prognostic tools help clinicians in counselling patients and relatives and guide therapeutic decisions. We aimed to methodologically assess prognostic tools for functional outcomes in severe spontaneous intracranial haemorrhages.
View Article and Find Full Text PDFJ Med Genet
April 2022
Normandie Univ, UNIROUEN, CHU Rouen, INSERM U1245, 76000 Rouen, Normandy Center for Genomic and Personalized Medicine, Rouen, France
Int J Infect Dis
March 2021
Regional University Hospital Centre Tours: Centre Hospitalier Regional Universitaire de Tours, Department of Diagnostic Neuroradiology, 2 boulevard Tonnellé, 37000 Tours Cedex 9, France. Electronic address:
J Neurointerv Surg
November 2021
Department of Neurosciences, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Background: There is a paucity of data regarding mechanical thrombectomy (MT) in distal arterial occlusions (DAO). We aim to evaluate the safety and efficacy of MT in patients with DAO and compare their outcomes with proximal arterial occlusion (PAO) strokes.
Methods: The Trevo Registry was a prospective open-label MT registry including 2008 patients from 76 sites across 12 countries.
Bone Joint Res
October 2020
Service de Médecine Interne et Maladies Infectieuses, Regional University Hospital Centre Tours, Tours, France.
Aims: The French registry for complex bone and joint infections (C-BJIs) was created in 2012 in order to facilitate a homogeneous management of patients presented for multidisciplinary advice in referral centres for C-BJI, to monitor their activity and to produce epidemiological data. We aimed here to present the genesis and characteristics of this national registry and provide the analysis of its data quality.
Methods: A centralized online secured database gathering the electronic case report forms (eCRFs) was filled for every patient presented in multidisciplinary meetings (MM) among the 24 French referral centres.
Thromb Haemost
March 2021
Institute for Immunology and Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.
Background: Heparin-induced thrombocytopenia (HIT) is typically caused by platelet-activating immunoglobulin G (IgG) antibodies (Abs) against platelet factor 4 (PF4) complexed with heparin (H). Much less frequent "autoimmune" HIT is distinguished from typical HIT by platelet activation without heparin and the presence of both anti-PF4/H and anti-PF4 IgG. We developed three murine monoclonal anti-PF4 Abs with a human Fc-part, 1E12, 1C12, and 2E1, resembling autoimmune HIT Abs.
View Article and Find Full Text PDFBMJ Support Palliat Care
September 2020
Palliative Care Team, Regional University Hospital Centre Tours, Tours, Centre-Val de Loire, France
Objectives: Patients with haematological malignancies (HM) receive more aggressive treatments near the end-of-life (EOL) than patients with solid tumours. Palliative care (PC) needs are less widely acknowledged in patients with multiple myeloma (MM) than in other HM. The main objective of our study was to describe EOL care and PC referral in a population of older patients with MM.
View Article and Find Full Text PDFAnn Rheum Dis
October 2020
Griffith University School of Medicine, Gold Coast, Queensland, Australia.
Objectives: SPIRIT head-to-head (H2H) is a 52-week (Wk) trial comparing ixekizumab (IXE) with adalimumab (ADA) for simultaneous American College of Rheumatology (ACR)50 and Psoriasis Area and Severity Index (PASI)100 responses in 566 patients (distributed evenly across both groups) with psoriatic arthritis (PsA). IXE was superior to ADA for this primary end point at Wk24. We aimed to determine the final efficacy and safety results through Wk52 including a prespecified subgroup analysis of concomitant conventional synthetic disease-modifying anti-rheumatic drugs (csDMARD) use.
View Article and Find Full Text PDFJ Neurointerv Surg
February 2020
Neuroradiology, Regional University Hospital Centre Tours, Tours, France.
Background: Thrombus composition has the potential to affect acute ischemic stroke (AIS) treatment.
Objective: To evaluate in an in vitro test the correlation of clot composition, especially erythrocytes (red blood cells (RBCs)), with the variation of signal intensity ratio (SIR) obtained with MRI sequences used for AIS, and qualification of the susceptibility vessel sign effect using clot analogs.
Materials And Methods: Nine ovine clots were fixed in a gelatin-manganese solution and studied by MRI (T2GE, T2-weighted gradient echo; SWI, susceptibility-weighted imaging; FLAIR, fluid attenuated inversion recovery).