25 results match your criteria: "Regional University Hospital Centre Tours[Affiliation]"

A gain of function variant in RGS18 candidate for a familial mild bleeding syndrome.

J Thromb Haemost

October 2024

National Institute of Health and Medical Research, National Research Institute for Agriculture, Food and Environment, Research Center for Cardiovascular and Nutrition, Faculty of Medicine, Aix Marseille University, Marseille, France; Reference Center on Constitutional Platelet Disorders, Biogenopole, University Hospital Center Timone, Public Assistance - Hospitals of Marseille, Marseille, France. Electronic address:

Background: Inherited platelet diseases are bleeding disorders characterized by either defects in platelet count or platelet function, the latter being less common and very heterogeneous. Numerous gene variants associated with abnormal receptors, granules, and signaling pathways have been reported. Despite significant advancements in our understanding, many patients still lack a precise diagnosis.

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  • The study aimed to compare the antibody response to SARS-CoV-2 in patients with inflammatory rheumatic diseases and healthy individuals.
  • Researchers screened unvaccinated patients with conditions like rheumatoid arthritis, spondyloarthritis, and psoriatic arthritis in France, and matched them with seropositive healthcare workers as controls.
  • Results showed no significant difference in antibody levels between both groups, with a trend indicating that patients with severe COVID-19 symptoms had higher antibody titres; treatments like glucocorticoids seemed linked to lower antibody responses.
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  • A study compared the effectiveness of IV tenecteplase and IV alteplase in patients undergoing thrombectomy for acute ischemic stroke, using data from the AcT trial.
  • It analyzed the outcomes of different endovascular thrombectomy strategies (stent retriever vs. aspiration) and how they interacted with the type of thrombolysis used.
  • Results indicated that while there was no overall difference in efficacy, tenecteplase was associated with better outcomes when paired with aspiration as the first-line strategy.
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Treatment breaks in an oncology unit.

BMJ Support Palliat Care

June 2024

Medical Oncology Department, Regional University Hospital Centre Tours, Tours, Centre-Val de Loire, France

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The use of 1E12, a monoclonal anti-platelet factor 4 antibody, to improve the diagnosis of vaccine-induced immune thrombotic thrombocytopenia.

J Thromb Haemost

August 2024

Department of Haemostasis, Regional University Hospital Centre Tours, Tours, France; Institut National de la Santé et de la Recherche Médicale INSERM U1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, Université de Tours, Tours, France.

Background: Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a complication of adenoviral-based vaccine against SARS-CoV-2 due to prothrombotic immunoglobulin (Ig) G antibodies to platelet factor 4 (PF4) and may be difficult to distinguish from heparin-induced thrombocytopenia (HIT) in patients treated with heparin.

Objectives: We assessed the usefulness of competitive anti-PF4 enzyme immunoassays (EIAs) in this context.

Methods: The ability of F(ab')2 fragments of 1E12, 1C12, and 2E1, 3 monoclonal anti-PF4 antibodies, to inhibit the binding of human VITT or HIT antibodies to PF4 was evaluated using EIAs.

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Background: Vascular phenotype is associated with a poor prognosis in systemic sclerosis (SSc). The identification of its risk factors could facilitate its early detection.

Objectives: To explore risk factors for a vascular phenotype of SSc, among them a history of pre-eclampsia.

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Laboratory and demographic predictors of functional assay positive status in suspected heparin-induced thrombocytopenia: A multicenter retrospective cohort study.

Thromb Res

September 2023

Department of Pharmacy Practice and Science, University of Arizona R. Ken Coit College of Pharmacy, Tucson, AZ, USA; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

Heparin-induced thrombocytopenia (HIT) is an antibody-mediated immune response against platelet factor 4 (PF4) bound to heparin anticoagulants. A priori identification of patients at-risk for HIT remains elusive and a number of risk factors have been identified, but these associations and their effect sizes have limited validation in large cohorts of suspected HIT patients. The aim of this study was to investigate existing anti-PF4/heparin antibody thresholds and model the relationship of demographic variables and anti-PF4/heparin antibody levels with functional assay positivity across multiple institutions in the absence of detailed clinical data.

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Magnesium ions are implicated in brain functioning. The disruption of brain metabolism subsequent to a perinatal hypoxic-ischaemic insult may be reflected by plasma magnesium. Infants at 36 weeks after birth or later with neonatal encephalopathy and who were admitted to our neonatal unit from 2011 to 2019 were retrospectively included.

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Background: The diagnosis of heparin-induced thrombocytopenia (HIT) requires functional assays to demonstrate that platelet factor 4 (PF4)-specific antibodies activate platelets, typically when therapeutic heparin (H) concentrations are tested ("classical" pattern). Some HIT samples also activate platelets without heparin ("atypical" pattern), but with unclear clinical significance.

Objectives: We aimed to assess whether platelet activation pattern and some characteristics of PF4-specific antibodies were associated with the severity of HIT.

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Introduction: The presence of median arcuate ligament (MAL) during orthotopic liver transplantation (OLT) may cause a significant reduction in the arterial hepatic flow. The aim of the present study is to investigate the impact of MAL on biliary complications in patients who underwent OLT.

Methods: We performed a retrospective case-control study among patients who underwent OLT in Geneva University Hospital between 2007 and 2017, depending on the presence or absence of MAL.

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  • The objective of the study was to create guidelines for therapeutic drug monitoring (TDM) of biopharmaceuticals used in inflammatory rheumatic and musculoskeletal diseases (RMDs), developed by a multidisciplinary task force from eight European countries.
  • The task force established six key principles and 13 specific points regarding TDM based on systematic literature reviews and expert agreement, with high levels of consensus (8.4 to 9.9 on a 10-point scale) on these recommendations.
  • The guidelines emphasize that while proactive TDM is generally not recommended, reactive TDM may be useful in certain cases; however, there is a need for more high-quality research to support its effectiveness and safety in
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  • Heparin, a common blood thinner, can cause heparin-induced thrombocytopenia (HIT) in some patients, leading to the production of antibodies against heparin and platelet factor 4 (PF4).
  • A genome-wide association study (GWAS) was conducted with over 4,000 patients of European ancestry to identify genetic variants influencing the levels of these anti-PF4/heparin antibodies.
  • The study found no significant genetic variants associated with antibody levels, suggesting that genetic differences are not a main cause of the variable antibody responses seen in heparin-treated patients.
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  • * A new multicentre study, called RECOVIDS, aims to explore how social vulnerability impacts recovery in patients who were hospitalized for ARDS related to COVID-19, incorporating both quantitative measurements and qualitative insights into patient experiences.
  • * The study will examine patients admitted to intensive care for severe COVID-19 and track their lung health six months post-discharge, focusing on identifying lung sequelae through various tests and assessing the role of socio-economic status in their rehabilitation process.
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In order to improve the safety of COVID-19 vaccines, there is an urgent need to unravel the pathogenesis of vaccineinduced immune thrombotic thrombocytopenia (VITT), a severe complication of recombinant adenoviral vector vaccines used to prevent COVID-19, and likely due to anti-platelet factor 4 (PF4) IgG antibodies. In this study, we demonstrated that 1E12, a chimeric anti-PF4 antibody with a human Fc fragment, fully mimics the effects of human VITT antibodies, as it activates platelets to a similar level in the presence of platelet factor 4 (PF4). Incubated with neutrophils, platelets and PF4, 1E12 also strongly induces NETosis, and in a microfluidic model of whole blood thrombosis, it triggers the formation of large platelet/leukocyte thrombi containing fibrin(ogen).

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  • - Heparin-induced thrombocytopenia (HIT) is a serious immune reaction linked to platelet factor 4 (PF4)/heparin complexes, prompting a genome-wide association study (GWAS) to identify genetic factors in different patient groups.
  • - A significant association was found between higher PF4/heparin IgG levels and positive functional assay results, with female sex also showing a weak association; an important genetic variant (rs8176719) in the ABO gene was identified as protective against HIT.
  • - The research suggests that individuals with O blood type are at increased risk for HIT and highlights the impact of the ABO gene on the condition, which could influence future clinical approaches.
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Objectives: Patients with severe spontaneous intracranial haemorrhages, managed in intensive care units, face ethical issues regarding the difficulty of anticipating their recovery. Prognostic tools help clinicians in counselling patients and relatives and guide therapeutic decisions. We aimed to methodologically assess prognostic tools for functional outcomes in severe spontaneous intracranial haemorrhages.

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  • The study investigates the clinical and genetic characteristics of β-galactosidase deficiency, focusing on two conditions: GM1-gangliosidosis and mucopolysaccharidosis IVB (MPSIVB).
  • Researchers analyzed data from 52 patients, finding a range of clinical symptoms in GM1-gangliosidosis from severe prenatal forms to adult onset.
  • The study identified numerous genetic variants, including 18 new ones, linking specific variants to distinct types of these disorders, ultimately aiming to improve patient classification and management.
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Background: There is a paucity of data regarding mechanical thrombectomy (MT) in distal arterial occlusions (DAO). We aim to evaluate the safety and efficacy of MT in patients with DAO and compare their outcomes with proximal arterial occlusion (PAO) strokes.

Methods: The Trevo Registry was a prospective open-label MT registry including 2008 patients from 76 sites across 12 countries.

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Aims: The French registry for complex bone and joint infections (C-BJIs) was created in 2012 in order to facilitate a homogeneous management of patients presented for multidisciplinary advice in referral centres for C-BJI, to monitor their activity and to produce epidemiological data. We aimed here to present the genesis and characteristics of this national registry and provide the analysis of its data quality.

Methods: A centralized online secured database gathering the electronic case report forms (eCRFs) was filled for every patient presented in multidisciplinary meetings (MM) among the 24 French referral centres.

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Background:  Heparin-induced thrombocytopenia (HIT) is typically caused by platelet-activating immunoglobulin G (IgG) antibodies (Abs) against platelet factor 4 (PF4) complexed with heparin (H). Much less frequent "autoimmune" HIT is distinguished from typical HIT by platelet activation without heparin and the presence of both anti-PF4/H and anti-PF4 IgG. We developed three murine monoclonal anti-PF4 Abs with a human Fc-part, 1E12, 1C12, and 2E1, resembling autoimmune HIT Abs.

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Objectives: Patients with haematological malignancies (HM) receive more aggressive treatments near the end-of-life (EOL) than patients with solid tumours. Palliative care (PC) needs are less widely acknowledged in patients with multiple myeloma (MM) than in other HM. The main objective of our study was to describe EOL care and PC referral in a population of older patients with MM.

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Objectives: SPIRIT head-to-head (H2H) is a 52-week (Wk) trial comparing ixekizumab (IXE) with adalimumab (ADA) for simultaneous American College of Rheumatology (ACR)50 and Psoriasis Area and Severity Index (PASI)100 responses in 566 patients (distributed evenly across both groups) with psoriatic arthritis (PsA). IXE was superior to ADA for this primary end point at Wk24. We aimed to determine the final efficacy and safety results through Wk52 including a prespecified subgroup analysis of concomitant conventional synthetic disease-modifying anti-rheumatic drugs (csDMARD) use.

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Background: Thrombus composition has the potential to affect acute ischemic stroke (AIS) treatment.

Objective: To evaluate in an in vitro test the correlation of clot composition, especially erythrocytes (red blood cells (RBCs)), with the variation of signal intensity ratio (SIR) obtained with MRI sequences used for AIS, and qualification of the susceptibility vessel sign effect using clot analogs.

Materials And Methods: Nine ovine clots were fixed in a gelatin-manganese solution and studied by MRI (T2GE, T2-weighted gradient echo; SWI, susceptibility-weighted imaging; FLAIR, fluid attenuated inversion recovery).

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