8 results match your criteria: "Regional University Hospital Center of Tours[Affiliation]"
Impact of age on surgical excision margins for vulvar squamous cell carcinomas: A multicenter study by the francogyn group.
Surg Oncol
November 2024
ECEVE U1123, National Institute of Health and Medical Research, Paris Cité University, Paris, France; Department of Obstetrics and Gynaecology, Lariboisiere University Hospital, University Paris Cité, Assistance Publique des Hôpitaux de Paris (AP-HP), Paris, France.
Article Synopsis
- Vulvar cancer primarily affects older women and requires surgical treatment, with guidelines emphasizing the importance of negative histological margins.
- A study analyzed the impact of patient age on surgical outcomes, finding that older patients (≥65 years) had larger tumors but similar rates of negative excision margins compared to younger patients (<65 years).
- Results indicated that younger patients experienced better recurrence-free survival and were more likely to undergo revision surgery despite the older group receiving more radical surgery.
First in Human Substernal Lead Extraction.
JACC Case Rep
September 2024
Cardiology Service, Regional University Hospital Center of Tours, Tours, France.
Article Synopsis
- A 49-year-old man had a substernal lead removed 2.5 years after it was implanted.
- The case report outlines the procedure's workflow and the experiences during the removal.
- This documentation highlights insights gained from the surgical process.
Impact of age on tumor size in vulvar cancer: A multicenter study by the Francogyn group.
Eur J Surg Oncol
September 2024
ECEVE U1123, National Institute of Health and Medical Research, Paris Cité University, Paris, France; Department of Obstetrics and Gynaecology, Lariboisiere University Hospital, University Paris Cité, Assistance Publique des Hôpitaux de Paris (AP-HP), Paris, France.
Objective: Vulvar cancer is a rare pathology affecting mainly elderly women. This study aims to evaluate the impact of age on tumor size in vulvar cancer.
Material And Methods: This was a multicenter retrospective observational study carried out between January 1, 1998, and December 31, 2020, in patients operated on for vulvar cancer.
Exploring the Immunomodulatory Potential of Human Milk: Aryl Hydrocarbon Receptor Activation and Its Impact on Neonatal Gut Health.
Nutrients
May 2024
Tytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Center, University of Amsterdam, 1105 BK Amsterdam, The Netherlands.
Article Synopsis
- * Researchers measured 21 tryptophan metabolites in the feces of full-term and preterm neonates, as well as in human milk and formula, finding higher levels in full-term babies.
- * Specific metabolites, particularly indole-3-lactic acid (ILA) and indole-3-acetic acid (IAA), showed the ability to reduce inflammation and maintain gut barrier integrity in cell models, highlighting the importance of these metabolites in early life gut health.
Risk factors for recurrence of borderline ovarian tumors in France: A multicenter retrospective study by the FRANCOGYN group.
J Gynecol Obstet Hum Reprod
April 2021
Department of Obstetrics and Gynaecology, Institute Alix de Champagne University Hospital, Reims Champagne Ardennes university, Reims, France. Electronic address:
Introduction: Borderline ovarian tumors (BOTs) although rare, have shown an increase in the incidence worldwide. Although the survival rate is high, the recurrence rate is estimated to be between 5% and 34%. The objective of this study was to identify risk factors for recurrence of BOTs.
View Article and Find Full Text PDFMechanism of dysfunction of human variants of the IRAK4 kinase and a role for its kinase activity in interleukin-1 receptor signaling.
J Biol Chem
September 2018
From the Inflammation and Immunology Research Unit, Pfizer Inc., Cambridge, Massachusetts 02139,
Interleukin-1 receptor (IL1R)-associated kinase 4 (IRAK4) is a central regulator of innate immune signaling, controlling IL1R and Toll-like receptor (TLR)-mediated responses and containing both scaffolding and kinase activities. Humans deficient in IRAK4 activity have autosomal recessive primary immune deficiency (PID). Here, we characterized the molecular mechanism of dysfunction of two IRAK4 PID variants, G298D and the compound variant R12C (R12C/R391H/T458I).
View Article and Find Full Text PDFVertical transmission of human African trypanosomiasis: Clinical evolution and brain MRI of a mother and her son.
PLoS Negl Trop Dis
July 2017
Department of Diagnostic and Interventional Radiology and Neuroradiology, Bretonneau Hospital, Regional University Hospital Center of Tours, Tours, France.
Non-invasive ventilation corrects alveolar hypoventilation during spinal anesthesia.
Can J Anaesth
April 2006
Department of Anesthesia and Critical Care, Regional University Hospital Center of Tours, Tours, France.
Purpose: To document and explain the beneficial effects of non-invasive ventilation in correcting hypoxemia and hypoventilation in severe chronic obstructive pulmonary disease, during spinal anesthesia in the lithotomy position.
Clinical Features: A morbidly obese patient with severe chronic obstructive pulmonary disease underwent prostate surgery in the lithotomy position under spinal anesthesia. Hypoxemia was encountered during surgery, and a profound decrease of forced vital capacity associated with alveolar hypoventilation and ventilation/perfusion mismatching were observed.