9 results match your criteria: "Regional House of Clinical Research[Affiliation]"
Incidence and risk factors for thromboembolic events in pediatric-onset inflammatory bowel disease: A French population-based study.
Dig Liver Dis
September 2024
Gastroenterology Unit, Amiens university Hospital, Amiens, France.
Article Synopsis
- Patients with inflammatory bowel disease (IBD), specifically children with Crohn's disease (CD) and ulcerative colitis (UC), have a higher risk of thromboembolic events (TE), but more information is needed regarding the incidence and risk factors for better preventative care.
- The study followed 1,344 pediatric patients from 1988 to 2013, finding very few instances of arterial (ATE) and venous thromboembolic events (VTE) during the follow-up period, with VTE being more frequent in specific circumstances.
- Overall, while the risk of TE in this population is low, it was significantly linked to periods of active disease, post-surgery conditions, and hospitalization, while treatment with
Predicting Penumbra Salvage and Infarct Growth in Acute Ischemic Stroke: A Multifactor Survival Game.
J Clin Med
July 2023
Stroke Center, Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Background: Effective treatment of acute ischemic stroke requires reperfusion of salvageable tissue. We investigated the predictors of penumbra salvage (PS) and infarct growth (IG) in a large cohort of stroke patients.
Methods: In the ASTRAL registry from 2003 to 2016, we selected middle cerebral artery strokes <24 h with a high-quality CT angiography and CT perfusion.
A Novel 8-Predictors Signature to Predict Complicated Disease Course in Pediatric-onset Crohn's Disease: A Population-based Study.
Inflamm Bowel Dis
November 2023
Amiens Hospital and University, Gastroenterology Unit, EPIMAD Registry, and PeriTox, UMR I-01, Amiens, France.
Background: The identification of patients at high risk of a disabling disease course would be invaluable in guiding initial therapy in Crohn's disease (CD). Our objective was to evaluate a combination of clinical, serological, and genetic factors to predict complicated disease course in pediatric-onset CD.
Methods: Data for pediatric-onset CD patients, diagnosed before 17 years of age between 1988 and 2004 and followed more than 5 years, were extracted from the population-based EPIMAD registry.
Long-term effectiveness and safety of anti-TNF in pediatric-onset inflammatory bowel diseases: A population-based study.
Dig Liver Dis
January 2024
Univ. Lille, Inserm, CHU Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, F-59000 Lille, France; Lille Hospital and University, Public Health, Epidemiology and Economic Health, France.
Article Synopsis
- Anti-TNF agents, commonly used to treat inflammatory bowel disease in patients diagnosed before age 17, show varied long-term effectiveness, especially in pediatric cases.
- A study of 1,007 Crohn's disease patients and 337 ulcerative colitis patients revealed significant failure rates for first-line anti-TNF therapy, with risks higher in the first year and female patients having increased rates of loss of response and intolerance.
- Despite 13.5% experiencing adverse events leading to treatment cessation, there were no deaths or serious conditions like cancer reported during anti-TNF therapy.
Natural History of Anal Ulcerations in Pediatric-Onset Crohn's Disease: Long-Term Follow-Up of a Population-Based Study.
Am J Gastroenterol
September 2023
Lille University Hospital, Public Health, Epidemiology, and Economic Health, EPIMAD Registry, Regional House of Clinical Research, Lille, France.
Article Synopsis
- Anal ulcerations are common in pediatric patients with Crohn's disease, with 25.6% experiencing them at diagnosis, and the 5 and 10-year cumulative incidence being 38.4% and 44.0%, respectively.
- Extraintestinal symptoms and locations of Crohn's disease in the upper digestive tract increase the risk of developing anal ulcerations, while ileal locations reduce that risk.
- A history of anal ulceration significantly raises the likelihood of developing fistulizing perianal Crohn's disease, with 23.3% of patients experiencing this after several years of follow-up.
Increased Risk of Cancer and Mortality in a Large French Population-Based Paediatric-Onset Inflammatory Bowel Disease Retrospective Cohort.
J Crohns Colitis
April 2023
Lille Hospital and University, Public Health, Epidemiology and Economic Health, EPIMAD registry, Regional house of clinical research, F-59000 Lille, France.
Background And Aims: Paediatric-onset IBD [pIBD] is associated with an increased risk of cancer and mortality in adulthood. The aims of this study were to measure the incidence of cancer and mortality in patients with pIBD and identify factors associated with mortality and cancer.
Methods: All patients diagnosed with Crohn's disease [CD] or ulcerative colitis [UC] before the age of 17 years between 1988 and 2011 in the EPIMAD registry were retrospectively followed until 2013 for cancer and 2015 for mortality.
Dramatic Increase in Incidence of Ulcerative Colitis and Crohn's Disease (1988-2011): A Population-Based Study of French Adolescents.
Am J Gastroenterol
February 2018
Public Health, Epidemiology and Economic Health, Epimad registry, Regional house of clinical research, Lille Hospital and University, Lille, France.
Objectives: Few data are available to describe the changes in incidence of pediatric-onset inflammatory bowel disease (IBD). The aim of this study was to describe changes in incidence and phenotypic presentation of pediatric-onset IBD in northern France during a 24-year period.
Methods: Pediatric-onset IBD (<17 years) was issued from a population-based IBD study in France between 1988 and 2011.
The IBD Disability Index should become a Major Secondary Endpoint in Clinical Practice and in Clinical Trials.
J Crohns Colitis
December 2016
Public Health, Epidemiology and Economic Health, EPIMAD registry, Regional House of Clinical Research, University Hospital, 59000, Lille, France.
Cancer and inflammatory bowel disease in the elderly.
Dig Liver Dis
October 2016
Inserm U954 and Department of Gastroenterology, Nancy University Hospital, Lorraine University, Vandœuvre-lès-Nancy, France.
Cancer may be a complication of inflammatory bowel disease (IBD) or its treatments. In older Crohn's disease and ulcerative colitis patients, the risk of malignancy is of particular concern. IBD diagnosis at an advanced age is associated with earlier development of colitis-associated colorectal cancer.
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