Sporadic deficient mismatch repair in colorectal cancer increases the risk for non-colorectal malignancy: A European multicenter cohort study.

Background And Objectives: Disparities between tumors arising via different sporadic carcinogenetic pathways have not been studied systematically. This retrospective multicenter cohort study evaluated the differences in the risk for non-colorectal malignancy between sporadic colorectal cancer (CRC) patients from different DNA mismatch repair status.

Methods: A retrospective European multicenter cohort study including in total of 1706 CRC patients treated between 1996 and 2019 in three different countries.

Performance of radiofrequency ablation used for metastatic spinal tumor: Numerical approach.

Surgical treatment of spine metastases follows only local anatomical and biomechanical objectives. Few cases of actual solitary metastases are rather exceptional, while removal of these metastases and the primary tumor may help to eradicate the process. The aim of our subsequent numerical simulations was to find out the temperature distribution and the volume lesion in a spinal tumor.

Applied anatomy of screw placement via the posterior arch of the atlas and anatomy-based refinements of the technique.

Purpose: To present a method of posterior arch and lateral mass screw (PALMS) insertion and to prove its feasibility.

Methods: Four formalin-fixed specimens and 40 macerated atlas vertebras were used to describe the relevant anatomy. The height of the posterior arch was measured on 42 consecutive patients using standard CT of the cervical spine.

The intraoperative portable CT scanner-based spinal navigation: a viable option for instrumentation in the region of cervico-thoracic junction.

Purpose: Innovative intraoperative imaging modalities open new horizons to more precise image acquisition and possibly to better results of spinal navigation. Planning of screw entry points and trajectories in this prospective study had been based on intraoperative imaging obtained by a portable 32-slice CT scanner. The authors evaluated accuracy and safety of this novel approach in the initial series of 18 instrumented surgeries in anatomically complex segment of cervico-thoracic junction.

Intraoperative portable CT-scanner based spinal navigation--a feasibility and safety study.

Background: Navigation based on an intraoperative CT scan is not a new approach to spinal instrumentation. Innovative intraoperative imaging technology, however, opens new horizons to more precise image acquisition as well as to further workflow. Planning of screw entry-points and trajectories in this study had been based on intraoperative imaging obtained by a portable 32-slice CT scanner.

Factors affecting sagittal malalignment due to cage subsidence in standalone cage assisted anterior cervical fusion.

Fusion of cervical spine in kyphotic alignment has been proven to produce an acceleration of degenerative changes at adjacent levels. Stand-alone cages are reported to have a relatively high incidence of implant subsidence with secondary kyphotic deformity. This malalignment may theoretically lead to adjacent segment disease in the long term.