4 results match your criteria: "Regional Fish Institute[Affiliation]"
FUT10 and FUT11 are protein O-fucosyltransferases that modify protein EMI domains.
Nat Chem Biol
January 2025
Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.
O-Fucosylation plays crucial roles in various essential biological events. Alongside the well-established O-fucosylation of epidermal growth factor-like repeats by protein O-fucosyltransferase 1 (POFUT1) and thrombospondin type 1 repeats by POFUT2, we recently identified a type of O-fucosylation on the elastin microfibril interface (EMI) domain of Multimerin-1 (MMRN1). Here, using AlphaFold2 screens, co-immunoprecipitation, enzymatic assays combined with mass spectrometric analysis and CRISPR-Cas9 knockouts, we demonstrate that FUT10 and FUT11, originally annotated in UniProt as α1,3-fucosyltransferases, are actually POFUTs responsible for modifying EMI domains; thus, we renamed them as POFUT3 and POFUT4, respectively.
View Article and Find Full Text PDFEstablishment of Star-edited Y1 cells as a novel in vitro functional assay for STAR.
J Mol Endocrinol
November 2024
Department of Pediatrics, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Article Synopsis
- - The study focuses on genetic variants of the STAR protein that lead to lipoid congenital adrenal hyperplasia, a condition marked by disrupted steroid production in adrenal glands and gonads.
- - Researchers created genetically modified Y1 mouse tumor cells, which showed a slight ability to produce pregnenolone, and displayed changes similar to those found in patients with the condition when stimulated for two weeks.
- - The modified cells can assess the functionality of both mouse and human STAR proteins, providing a new way to study genetic variants linked to steroidogenesis issues.
Alterations in the fillet quality of -knockout red sea bream : Preliminary insights into nutritional, compositional, and textural properties.
Heliyon
June 2024
Regional Fish Institute, Ltd. Yoshida-Honmachi, Sakyo-ku, Kyoto, 606-8501, Japan.
Article Synopsis
- * The study evaluated how the absence of myostatin affects the quality of red sea bream fillets during refrigeration.
- * Results showed that the mutant fish had higher moisture retention and lower collagen content, leading to improved water-holding capacity but a softer texture compared to regular fillets.
A novel symbiotic relationship between ascidians and a new tunic-boring polychaete (Annelida: Spionidae: Polydora).
Zootaxa
June 2022
Laboratory of Biological Oceanography, Graduate School of Agricultural Science, Tohoku University, Aramaki-Aza-Aoba 468-1, Aoba-ku, Sendai-shi, Miyagi 980-8572, Japan..
Polydora tunicola Abe, Hoshino Yamada, sp. nov., a new spionid species currently considered an obligate symbiont of styelid ascidians, is described based on materials collected from Polycarpa cf.
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