Gilteritinib versus salvage chemotherapy in predominantly Asian patients with relapsed/refractory FLT3-mutated acute myeloid leukemia: a regional analysis of COMMODORE in China, South-East Asia, and Russia.

The COMMODORE study demonstrated the efficacy and safety of gilteritinib versus salvage chemotherapy (SC) treatment in a predominantly Asian population with relapsed/refractory (R/R) FMS-like tyrosine kinase 3 (FLT3)-mutated() acute myeloid leukemia (AML); here we present an exploratory analysis of the study stratified by region (China, South-East Asia and Russia). COMMODORE was a Phase 3, open-label, randomized (1:1), multicenter trial. There were 151, 50, and 33 patients in the China, South-East Asia, and Russia cohorts, respectively.

Multifactorial Prediction of the Risk of Hospital Mortality in Patients With Acute Coronary Syndrome.

Aim      To identify predictors for the risk of in-hospital death and to develop a prognostic scale for individual risk of death in patients with acute coronary syndrome (ACS) at the hospital stage of treatment.Material and methods  A sequential retrospective analysis was conducted, including 225 patients with ACS (n=101, main group of patients who died in hospital; n=124, control group) hospitalized in the Regional Vascular Center #2 of the Semashko Nizhny Novgorod Regional Clinical Hospital from January, 2021 through July, 2022. Clinical, demographic, laboratory and instrumental characteristics of patients were studied.

Early multimodal neurointerventional and neurosurgical management of penetrating craniocerebral injuries: wartime experience from Ukraine.

Objective: The war in Ukraine has resulted in a large number of penetrating head wounds with concomitant neurovascular injuries. The aim of this report was to review these patients and demonstrate a multimodal treatment approach used for these complex injuries. This entails a combination of early endovascular and open surgical treatment for optimal outcome.

[Method of linear calibration function control according to GOST R ISO 11095-2007 for measuring the mass concentration of ethanol].

Objective: Implementation of the control method to validate previously obtained calibration functions according to GOST R ISO 11095-2007 using Reference Materials (RM): standard RMs - aqueous solutions of ethanol, produced and certified by the organization, and internal RMs - aqueous solutions of ethanol in different concentrations, developed by the user for internal use.

Material And Methods: We applied the control method in accordance with the National Standard of the Russian Federation GOST R ISO 11095-2007 using the standard and internal RMs - aqueous ethanol solutions in different concentrations. Measurements were performed for two subranges of ethanol concentrations on standard and internal RMs in accordance with the certified method.

Changes in the Level of hs-CRP in the Blood and Morphometric Parameters of Tissues Following Implantation of Polypropylene.

In recent decades, the use of polypropylene meshes has been the gold standard in the surgical treatment of muscular corset failure. However, the reasons behind the low percentage of complications and recurrences remain controversial. Tissue hyperreactivity and the immune response to polypropylene may be contributing factors.

Assessing the Clinical Relevance of Soluble PD-1 and PD-L1: A Multi-Cohort Study Across Diverse Tumor Types and Prognostic Implications.

Immune checkpoint inhibitors targeting the PD-1/PD-L1 pathway have revolutionized cancer immunotherapy, however the clinical relevance of their soluble forms (sPD-1 and sPD-L1) remains less studied. Soluble PD-1 and PD-L1 have been implicated in tumor progression, prognosis, and treatment response across various malignancies. This study aims to provide a comprehensive analysis of sPD-1 and sPD-L1 levels in serum across diverse tumor types, including rare malignancies, and to evaluate their associations with clinicopathological characteristics and prognostic significance.

A phase III study comparing preservative-free latanoprost eye drop emulsion with preserved latanoprost in open-angle glaucoma or ocular hypertension.

Background/objectives: To evaluate the efficacy and safety of preservative-free latanoprost eye drop emulsion in reducing intraocular pressure (IOP) versus preserved latanoprost in open-angle glaucoma (OAG) or ocular hypertension (OHT).

Methods: A Phase III non-inferiority study randomised patients with OAG/OHT 1:1 to receive preservative-free latanoprost eye drop emulsion or preserved latanoprost. The primary efficacy endpoint was change from baseline in peak (9:00 A.

Perineuromal hydrodissection for acute postamputation pain? An observational study in a time of war.

Introduction: This exploratory study investigates the potential of perineuromal hydrodissection as an adjunct to opioid therapy for postamputation pain, specifically focusing on residual limb and phantom limb pain (PLP). Given the correlations between acute pain and the development of chronic pain, the primary aims were to estimate the effect size of early hydrodissection of scar tissue around residual limb neuroma(s) and to identify the best time frame for treatment.

Methods: Seventy-four patients with war-related limb amputations and painful neuromas were included in this observational analysis.

Maintenance Therapy With Avelumab for Patients With Metastatic Urothelial Carcinoma: A Real-World, Ambispective RAVE-Bladder Study.

Background: This ambispective study was designed to assess the efficacy and safety of avelumab maintenance in a real-world population of patients with metastatic urothelial cancer (UC).

Methods: Patients with metastatic UC and measurable disease that had not progressed following first-line platinum-based chemotherapy were treated with maintenance avelumab (800 mg administered every 2 weeks). The primary endpoint was overall survival (OS).

Combined genomics and proteomics unveils elusive variants and vast aetiologic heterogeneity in dystonia.

Dystonia is a rare-disease trait for which large-scale genomic investigations are still underrepresented. Genetic heterogeneity among patients with unexplained dystonia warrants interrogation of entire genome sequences, but this has not yet been systematically evaluated. To significantly enhance our understanding of the genetic contribution to dystonia, we (re)analyzed 2,874 whole-exome sequencing (WES), 564 whole-genome sequencing (WGS), as well as 80 fibroblast-derived proteomics datasets, representing the output of high-throughput analyses in 1,990 patients and 973 unaffected relatives from 1,877 families.

[Epidemiology of multiple sclerosis in the city of Novosibirsk].

Objective: To study the dynamics of the epidemiological characteristics of multiple sclerosis (MS) from 01.01.2003 to 01.

Management of refractory postpneumonectomy empyema with bronchopleural fistula.

A 39-year-old female has postoperative empyema with bronchial stump fistula (BSF) after pneumonectomy due to ineffective tuberculosis chemotherapy. Transpleural reamputation of the right main bronchial stump with simultaneous 8-rib thoracoplasty, 6 attempts at endobronchial valve implantation and thoracostomy have failed to cure BSF and empyema. Consequently, an alternative treatment-transsternal transpericardial wedge-shaped resection of the tracheal bifurcation was performed despite its difficulty and was successful.

[Ascending aorta and aortic arch replacement without circulatory arrest].

Circulatory arrest is the main method used in surgical interventions for prosthetics of the proximal aorta. However, recently, facts have been discovered that prove the benefits of avoiding circulatory arrest during planned and emergency surgical interventions. We present a clinical case of planned prosthetics of the ascending section and the aortic arch with a Intergard Woven 28 mm multibranch prosthesis without circulatory arrest in conditions of mild hypothermia.

[Choosing the optimal surgical method for duodenal ulcer complicated by bleeding].

The treatment tactics for gastrointestinal bleeding (GIB), recommended by surgical societies, involve a certain sequence of actions taking into account the capabilities of the clinical institution. A mandatory requirement for all levels of care is the stabilization of post-hemorrhagic disorders and stopping bleeding by any available means. A mandatory requirement for all levels of care is the stabilization of post-hemorrhagic disorders and stopping bleeding by any available means.

[Treatment of patients with external intestinal fistulas and widespread peritoneal adhesions].

Objective: To substantiate the safe timing and volume of enterolysis during operative treatment of patients with external small intestinal fistulas against the background of widespread peritoneal adhesive process.

Material And Methods: Comparative results of treatment of 315 adult patients, divided into 3 groups (60, 74 and 181 patients), depending on the graduation of peritoneal adhesive process, timing of operations and volumes of enterolysis are presented.

Results: The highest postoperative mortality (17 (6.

Distant ureteric metastasis of prostate cancer four years post radical prostatectomy.

We describe a case of a 78-year-old male with a history of Gleason score 9 prostate cancer treated with a robotic-assisted radical prostatectomy, who developed symptoms of right ureteric obstruction four years later. Diagnostic evaluation revealed right sided hydroureteronephrosis on imaging. Further correlation with prostate specific antigen (PSA) and histopathology from a distal ureterectomy with reimplantation revealed metastatic prostate cancer as the cause of obstruction with incidental focal carcinoma in situ (CIS) also identified.

Rare Cause 5q SMA: Molecular Genetic and Clinical Analyses of Intragenic Subtle Variants in the SMN Locus.

Spinal muscular atrophy 5q (5q SMA) is one of the most prevalent autosomal recessive disorders globally. The underlying cause of 5q SMA is attributed to variants in SMN1. Exon 7 of SMN1 is not detectable in major of probands with 5q SMA, and minor of probands have a combination of the deletion and an intragenic subtle variant in the second allele.

[Aortic valve reimplantation combined with total arch replacement in type A aortic dissection].

We present simultaneous aortic valve reimplantation, replacement of aortic arch, right common carotid artery and proximal parts of the right subclavian and left common carotid arteries in a patient with type I aortic dissection. Involvement of supra-aortic arteries is the main predictor of cerebral malperfusion and mortality in acute aortic dissection. Optimal surgical intervention in such patients is still unclear.

Prospective trial of the Oncobox platform RNA sequencing bioinformatic analysis for personalized prescription of targeted drugs.

Interrogating gene expression in tumor can identify up- and downregulated molecular targets of cancer drugs. Here we report the results of prospective clinical investigation of using RNA sequencing analysis for personalized cancer therapy. Transcriptomic profiles were analyzed using Oncobox platform that identifies altered expression of drug target genes and molecular pathways and builds a personalized rating of targeted therapeutics.

Prolgolimab with chemotherapy as first-line treatment for advanced non-squamous non-small-cell lung cancer.

Background: Prolgolimab is an IgG1 anti-PD-1 monoclonal antibody with the Fc-silencing 'LALA' mutation. The phase III DOMAJOR study assessed efficacy and safety of prolgolimab in combination with pemetrexed and platinum-based chemotherapy vs placebo in combination with pemetrexed and platinum-based chemotherapy as first-line treatment for advanced non-small cell lung cancer (NSCLC).

Methods: 292 patients with advanced non-squamous NSCLC were randomized 1:1 to receive 4 cycles of pemetrexed, platinum-based drug and either prolgolimab (3 mg/kg Q3W) or placebo followed by prolgolimab/placebo with pemetrexed until disease progression or toxicity (≤36 months).

Change of the anterior talus-fibular ligament length of asymptomatic patients during inversion stress test.

Objective: Aim: To study the ATFL length among asymptomatic population of young patients on both joints by using the method of ultrasound examination of the ankle joint and applying the inversion stress test.

Patients And Methods: Materials and Methods: the length of the ATFL was measured among 60 boys and 60 girls during the research. Sonography was performed on both joints, in each of the two studied positions, three times per position in order to obtain the average ligament length.

Interrelationships of the Intestinal Microbiome, Trimethylamine N-Oxide and Lipopolysaccharide-Binding Protein with Crohn's Disease Activity.

Unlabelled: Crohn's disease (CD) is a multifactorial inflammatory bowel disease whose pathogenetic mechanisms are a field of ongoing study. Changes in the intestinal microbiome in CD may influence metabolite production and reflect the disease's severity. We investigate the relationship between trimethylamine N-oxide (TMAO) and lipopolysaccharide-binding protein (LPS) levels and changes in the gut microbiome in patients with CD of various degrees of activity.

Real-World Efficacy and Safety of Avelumab Plus Axitinib in Metastatic Renal Cell Carcinoma: Results from the Ambispective RAVE-Renal Study.

Background: The RAVE-Renal study was conducted to evaluate the real-world efficacy and safety of avelumab plus axitinib as a first-line therapy for patients with metastatic renal cell carcinoma (mRCC).

Methods: RAVE-Renal was a multicenter, noninterventional, ambispective study with both retrospective and prospective components. The study included adult patients with histologically confirmed mRCC, measurable disease per RECIST version 1.