A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_session70subn16lfg6qn8ooem30q8p5to61dod): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

Regional Cancer Center[Affiliation] Publications | LitMetric

1,648 results match your criteria: "Regional Cancer Center[Affiliation]"

Introduction: Patients with cancer experience physical, mental, and social pain that affects themselves and their families. The increasing cancer incidence and advances in treatment have increased the number of cancer survivors in Korea, and there is an influx of patients in Seoul and other metropolitan areas, leading to shortages of continuous care and comprehensive life support facilities. Patients must travel long distances for treatment, which poses logistical and quality-of-life challenges.

View Article and Find Full Text PDF

Background: This prospective cohort study aimed to assess whether postoperative radiotherapy could safely be omitted in women ≥ 65 years with low-risk, estrogen receptor (ER)-positive T1N0 breast cancer treated with breast-conserving surgery and adjuvant endocrine therapy.

Methods: Eligible patients were women ≥ 65 years with unifocal, non-lobular, grade 1 or 2, ER-positive, pT1N0 breast cancer treated with breast-conserving surgery and endocrine therapy for five years. Patients were followed up with mammography at least annually for 10 years.

View Article and Find Full Text PDF

Purpose: Identifying the palliative care needs of patients with advanced cancer is important for maintaining quality of life and timely transition to palliative care. We aimed to validate the Korean Sheffield Profile for Assessment and Referral for Care (K-SPARC) in such patients and establish its psychometric properties, including reliability, validity, and responsiveness to change.

Materials And Methods: We used the forward-back translated version of SPARC, which was verified through a pilot study, to assess the palliative care needs of patients with advanced cancer.

View Article and Find Full Text PDF

Background: Mirvetuximab soravtansine-gynx (MIRV) is a first-in-class, folate receptor alpha (FRα)-targeting antibody-drug conjugate with US Food and Drug Administration approval for FRα-positive platinum-resistant ovarian cancer. PICCOLO is a phase 2, global, open-label, single-arm trial of MIRV as third-line or greater (≥3L) treatment in patients with FRα-positive (≥75% of cells with ≥2+ staining intensity) recurrent platinum-sensitive ovarian cancer (PSOC).

Patients And Methods: Participants received MIRV (6 mg/kg adjusted ideal body weight every 3 weeks) until progressive disease (PD), unacceptable toxicity, withdrawal of consent, or death.

View Article and Find Full Text PDF

we propose equity in representation on who hosts cancer related conferences! It's time for Low and middle income to also rent their academic spaces!, this unfortunately is one of the ways to sort the visa injustices for cancer care providers in LMICs.

View Article and Find Full Text PDF

Recent epidemiological and experimental studies have increasingly highlighted the association between environmental pollution, especially ultrafine particulate matter (PM), and the risk of neurodegenerative diseases, such as Parkinson's disease (PD). These previous studies suggest a potential mechanism by which ultrafine PM contributes to neuronal damage through processes, such as iron accumulation and oxidative stress. In this study, we aimed to elucidate the effects of ultrafine PM on ferroptosis, an iron-dependent form of cell death, in the mouse substantia nigra pars compacta (SNc) and to evaluate the protective role of α-lipoic acid (ALA).

View Article and Find Full Text PDF

Background: Bortezomib (B), known as Velcade, is a reversible proteasome inhibitor approved for relapsed/refractory multiple myeloma (RRMM) patients (pts). The standard of care protocol includes eight cycles of intravenous push (IVP) injections of B and oral dexamethasone (D), which increases the toxicity. Here, we describe the results of an open-label, phase II clinical trial employing only four cycles of B/D.

View Article and Find Full Text PDF

Background: Varying obesogenic inherited predisposition in early to later life may differentially impact colorectal cancer (CRC) development. Previous Mendelian randomization (MR) studies, conducted in populations of European genetic similarity, have not observed any significant associations between early life body weight with CRC risk. However, it remains unclear whether body mass index (BMI) at different early lifetime points is causally related with CRC risk in both Europeans and East Asian populations.

View Article and Find Full Text PDF
Article Synopsis
  • * Results showed that a higher PRS was more strongly related to EGFR-positive LUAD cases (OR=8.63) than to EGFR-negative cases (OR=3.50), indicating a significant association based on mutation status.
  • * These findings imply that genetic susceptibility to LUAD differs in never-smoking East Asian women depending on whether the cancer has specific mutations, which could affect public health strategies and clinical practices.*
View Article and Find Full Text PDF

Navigating shared decision-making after the Life-Sustaining Treatment Decision Act: a qualitative study of in-depth interviews with terminal cancer patients, families, and healthcare professionals.

Support Care Cancer

November 2024

College of Nursing, The Research Institute of Nursing Science, Center for Human-Caring Nurse Leaders for the Future By Brain Korea 21 (BK 21) Four Project, Seoul National University, Seoul, Republic of Korea.

Purpose: End-of-life decision-making, particularly relating to withholding life-sustaining treatment (LST), is a complex and emotionally charged process involving healthcare professionals, patients, and caregivers.

Methods: This qualitative study explored the decision-making process in South Korea, where cultural norms and ethical considerations influence the dynamics of shared decision-making (SDM). In-depth interviews were conducted with healthcare professionals, patients, and caregivers using a grounded theory approach to elucidate the themes and processes underlying SDM for LST.

View Article and Find Full Text PDF

Purpose: Squamous cell carcinoma of the head and neck (SCCHN) is the sixth most common cancer, with approximately 225,419 new cases with over 125,000 deaths annually in India. This trial compared the efficacy and safety of biosimilar cetuximab versus innovator cetuximab (IC) in combination with platinum-based chemotherapy in patients with recurrent locoregional or metastatic SCCHN.

Methods: This phase III trial is a multicenter, randomized, double-blind and parallel group study performed in Indian patients with recurrent locoregional or metastatic SCCHN.

View Article and Find Full Text PDF

Purpose: The purpose of this study was to systematically examine the normal tissue objective (NTO) function by comparing its variations for planning solitary brain metastasis with intensity-modulated and volumetric-modulated arc radiosurgery techniques.

Materials And Methods: Twenty-two cases were retrospectively planned with two NTO parameter sets named A and B using intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) techniques. The Type A set used slope, k = 0.

View Article and Find Full Text PDF

Danish and Swedish National Data Collections for Cancer - Solutions for Radiotherapy.

Clin Oncol (R Coll Radiol)

October 2024

Laboratory of Radiation Physics, Odense University Hospital, Denmark; Institute of Clinical Research, University of Southern Denmark, Denmark; Danish Center of Particle Therapy, Aarhus University Hospital, Denmark.

Collecting large amounts of radiotherapy (RT) data from clinical systems is known to be a challenging task. Still, data collections outside the original RT systems are needed to follow-up on the quality of cancer care and to improve RT. This paper aims to describe how RT data is collected nationally in Denmark and Sweden for this purpose and gives an overview of the stored information in both countries' national data sources.

View Article and Find Full Text PDF

Background: Young patients ≤ 50 years old with multiple myeloma (MM) account for about 10% of cases and are underrepresented in the literature.

Methods: We explored disease characteristics, treatments, and outcomes following modern therapies of young MM patients using the Canadian Myeloma Research Group (CMRG) database. We included 493 patients ≤ 50 years old diagnosed with MM or plasma cell leukemia without concurrent amyloidosis or POEMS syndrome from January 1, 2010, to July 1, 2022.

View Article and Find Full Text PDF
Article Synopsis
  • Discordant lymphomas refer to the occurrence of two or more different types of lymphomas in the same patient, making diagnosis challenging.
  • Limited literature on discordant lymphomas exists due to their rarity, resulting in a lack of established treatment guidelines.
  • The article discusses a case involving a young man with both large B-cell lymphoma and classic Hodgkin lymphoma, highlighting the need for thorough biopsies and innovative treatment approaches like immune checkpoint inhibitors.
View Article and Find Full Text PDF
Article Synopsis
  • Neonatal mortality is a significant issue in under-five deaths, and postnatal education can help mothers recognize and seek care for conditions like neonatal jaundice, which often goes undetected due to a lack of knowledge.
  • A qualitative study evaluated a neonatal jaundice education program at Jinja Regional Referral Hospital, collecting data from 12 postnatal women through unstructured interviews to understand their experiences.
  • Findings revealed that participants valued the education program highly, noting its tailored approach and ability to enhance care-seeking, but some suggested that limited group interaction could hinder its effectiveness.
View Article and Find Full Text PDF

Human papillomavirus-based cervical screening and long-term cervical cancer risk: a randomised health-care policy trial in Sweden.

Lancet Public Health

November 2024

Center for Cervical Cancer Elimination, Medical Diagnostics Karolinska, Karolinska University Hospital and Department of CLINTEC, Karolinska Institutet, Stockholm, Sweden. Electronic address:

Background: Human papillomavirus (HPV)-based cervical screening is a globally recommended public health policy. Randomised clinical trials find superior performance of primary HPV-based screening compared with cytology for preventing cervical cancer. However, additional evidence from real-world public health policies is needed.

View Article and Find Full Text PDF

Introduction: Obinutuzumab is hypothesized to improve progression-free survival (PFS) combined with bendamustine induction in mantle cell lymphoma (MCL). Measurable-residual disease (MRD) testing may predict benefit from maintenance therapy.

Methods: Adults (≥ 18 years) with untreated MCL ineligible for intensive therapies received 4 to 6 cycles of bendamustine + obinutuzumab (BO) followed by consolidation obinutuzumab (CO).

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the MedEvac program, which transferred Ukrainian cancer patients to EU hospitals during the 2022 Russian invasion, highlighting the urgent need for specialized cancer care in conflict zones.
  • Out of 639 applications, 339 were analyzed, revealing that 82.9% of those had enough data for the analysis, and a significant majority were evacuated for systemic cancer therapy, with newly diagnosed patients being the most common.
  • The findings emphasize that a good performance status greatly increased the chances of evacuation, suggesting the MedEvac program could serve as a model for handling medical crises in war-torn regions, requiring ongoing assessment for effectiveness.
View Article and Find Full Text PDF
Article Synopsis
  • The study evaluated how COVID-19 distancing measures affected cancer diagnostic activities, specifically gastrointestinal endoscopy (GIE), by comparing data from 2020-2022 with 2018-2019.
  • Using data from the Korean Health Insurance Review and Assessment Services, it found a drop in age-standardized rates for colonoscopy and endoscopic gastroduodenoscopy (EGD) in 2020, but a subsequent rise in 2021-2022, with some exceptions for EGD in lower-income populations.
  • The results highlighted socioeconomic inequalities in the recovery rates of GIE and emphasized the importance of implementing equity-focused strategies to improve healthcare access across different social groups post-pandemic
View Article and Find Full Text PDF
Article Synopsis
  • Hypoalbuminemia is prevalent in cancer patients, particularly those with advanced solid tumors, and its impact on the safety of high-protein-bound tyrosine kinase inhibitors (TKIs) is under-researched.
  • A study examined 282 patients taking oral TKIs, finding that those with hypoalbuminemia had a significantly shorter median time on treatment and experienced more severe adverse events compared to those with normal albumin levels.
  • The findings suggest that patients with hypoalbuminemia are at a higher risk of adverse events and require careful monitoring when undergoing TKI therapy.
View Article and Find Full Text PDF

Lung transplantation (LTx) is a well-known treatment for end-stage lung disease. This study aimed to report the incidence of cancer after LTx and long-term outcome among lung transplant recipients with a pretransplant diagnosis of cancer. Patients who underwent LTx between 1990-2016 were included in the study.

View Article and Find Full Text PDF

Heart transplant patients have an increased risk of developing cancer. Patients who underwent HTx between 1985 and 2017 were included. Detection of cancer was obtained by cross-checking the study population with the Swedish Cancer-Registry and the Cause-of-Death-Registry.

View Article and Find Full Text PDF