Accumulation of cholesterol, triglycerides and ceramides in hepatocellular carcinomas of diethylnitrosamine injected mice.

Background: Dysregulated lipid metabolism is critically involved in the development of hepatocellular carcinoma (HCC). The respective metabolic pathways affected in HCC can be identified using suitable experimental models. Mice injected with diethylnitrosamine (DEN) and fed a normal chow develop HCC.

Postoperative delirium is a risk factor for complications and poor outcome after total hip and knee arthroplasty.

Background and purpose - Improving health care and demographic change have resulted in a steady increase in geriatric patients undergoing total hip (THA) and knee (TKA) arthroplasty. Postoperative delirium (POD) is a frequent and severe complication after major surgery. Therefore, we analyzed the impact of POD on outcome after THA and TKA.

Systematic Evaluation of Fluorination as Modification for Peptide-Based Fusion Inhibitors against HIV-1 Infection.

With the emergence of novel viruses, the development of new antivirals is more urgent than ever. A key step in human immunodeficiency virus type 1 (HIV-1) infection is six-helix bundle formation within the envelope protein subunit gp41. Selective disruption of bundle formation by peptides has been shown to be effective; however, these drugs, exemplified by T20, are prone to rapid clearance from the patient.

The Mechanisms Underlying Interference and Inhibition: A Review of Current Behavioral and Neuroimaging Research.

The memory literature has identified interference and inhibition as two major sources of forgetting. While interference is generally considered to be a passive cause of forgetting arising from exposure to additional information that impedes subsequent recall of target information, inhibition concerns a more active and goal-directed cause of forgetting that can be achieved intentionally. Over the past 25 years, our knowledge of the neural mechanisms underlying both interference-induced and inhibition-induced forgetting has expanded substantially.

A novel radiological classification for displaced os coccyx: the Benditz-König classification.

Background: Treatment of coccygodynia is still a challenging entity. Clear surgical selection criteria are still lacking. The aim of the investigation was to establish a novel radiological classification for surgical decision-making in coccygodynia cases.

Leukoaraiosis severity and post-reperfusion outcomes in acute ischaemic stroke: A meta-analysis.

Objectives: Severity of leukoaraiosis may mediate outcomes after reperfusion therapy in acute ischaemic stroke (AIS) patients. However, the level of the association remains poorly understood. We performed a meta-analysis to investigate the impact of leukoaraiosis severity on functional outcome, survival, haemorrhagic complications, and procedural success in AIS patients treated with intravenous thrombolysis and/or endovascular thrombectomy.

The tumor patient in the COVID-19 pandemic-an interview-based study of 30 patients undergoing systemic antiproliferative therapy.

Introduction: Five months after COVID-19 first occurred and protective regulations were introduced, patients at three outpatient hematological/oncological centers in Bavaria who had received antiproliferative tumor therapy (n = 30) were questioned about the pandemic's impact.

Patients, Materials And Methods: In recorded semi-structured telephone interviews, the patients answered questions about their quality of life, treatment procedures, their relationship with medical care staff and modern communication technologies. Each interview consisted of 28 questions.

Small head movements increase and colour noise in data from five video-based P-CR eye trackers.

We empirically investigate the role of small, almost imperceptible balance and breathing movements of the head on the level and colour of noise in data from five commercial video-based P-CR eye trackers. By comparing noise from recordings with completely static artificial eyes to noise from recordings where the artificial eyes are worn by humans, we show that very small head movements increase levels and colouring of the noise in data recorded from all five eye trackers in this study. This increase of noise levels is seen not only in the gaze signal, but also in the P and CR signals of the eye trackers that provide these camera image features.

Surgical Drill Guide for Insertion of an Infra-Acetabular Screw Based on an Anatomically Precontoured Plate System: A Cadaveric Study.

Purpose: Due to the anatomic structure of the pelvis, free-hand placement of screws in the acetabular fracture management can be difficult. Infra-acetabular screw fixation increases acetabular stability by distal fixation of the cup. Aim of this cadaveric study is to investigate if a plate-referenced drill guide can provide save placement of an infra-acetabular screw over a precontoured suprapectineal quadrilateral buttress plate (SQBP).

Improved risk estimation of locoregional recurrence, secondary contralateral tumors and distant metastases in early breast cancer: the INFLUENCE 2.0 model.

Purpose: To extend the functionality of the existing INFLUENCE nomogram for locoregional recurrence (LRR) of breast cancer toward the prediction of secondary primary tumors (SP) and distant metastases (DM) using updated follow-up data and the best suitable statistical approaches.

Methods: Data on women diagnosed with non-metastatic invasive breast cancer were derived from the Netherlands Cancer Registry (n = 13,494). To provide flexible time-dependent individual risk predictions for LRR, SP, and DM, three statistical approaches were assessed; a Cox proportional hazard approach (COX), a parametric spline approach (PAR), and a random survival forest (RSF).

Development of Randomized Trials in Adults with Medulloblastoma-The Example of EORTC 1634-BTG/NOA-23.

Medulloblastoma is a rare brain malignancy. Patients after puberty are rare and bear an intermediate prognosis. Standard treatment consists of maximal resection plus radio-chemotherapy.

Correction to: Temporary materials: comparison of in vivo and in vitro performance.

A Correction to this paper has been published: https://doi.org/10.1007/s00784-021-04067-4.

Bilateral septic arthritis with rapid progressive destruction of the femoral head after joint injection in rheumatoid arthritis.

This report is on a 61-year-old patient with steroid therapy for rheumatoid arthritis and pain in the groin on both sides who got injections with hyaluronic acid in both hip joints. After 12 weeks the X-ray of the pelvis showed rapid progressive destruction of both hip joints.

Perception of biological motion by jumping spiders.

The body of most creatures is composed of interconnected joints. During motion, the spatial location of these joints changes, but they must maintain their distances to one another, effectively moving semirigidly. This pattern, termed "biological motion" in the literature, can be used as a visual cue, enabling many animals (including humans) to distinguish animate from inanimate objects.

Self-paced part-list cuing.

Ironically, the presentation of a subset of studied material as retrieval cues at test often impairs recall of the remaining (target) material-an effect known as part-list cuing impairment. Part-list cues are typically provided at the beginning of the recall period, a time when nearly all individuals would be able to recall at least some studied items on their own. Across two experiments, we examined the effects of part-list cuing when student participants could decide on their own when the cues were presented during the recall period.

Emerging role of white matter lesions in cerebrovascular disease.

White matter lesions have been implicated in the setting of stroke, dementia, intracerebral haemorrhage, several other cerebrovascular conditions, migraine, various neuroimmunological diseases like multiple sclerosis, disorders of metabolism, mitochondrial diseases and others. While much is understood vis a vis neuroimmunological conditions, our knowledge of the pathophysiology of these lesions, and their role in, and implications to, management of cerebrovascular diseases or stroke, especially in the elderly, are limited. Several clinical assessment tools are available for delineating white matter lesions in clinical practice.

Management and Outcomes of Patients with Isolated Superficial Vein Thrombosis under Real Life Conditions (INSIGHTS-SVT).

Objective: Management and outcomes of superficial vein thrombosis (SVT) are highly variable and not well described. Therefore, the INvestigating SIGnificant Health TrendS in the management of SVT (INSIGHTS-SVT) study collected prospective data under real life conditions.

Methods: Prospective observational study of objectively confirmed acute isolated SVT.

Serum Amyloid Beta42 Is Not Eliminated by the Cirrhotic Liver: A Pilot Study.

Amyloid-beta (Aβ) deposition in the brain is the main pathological hallmark of Alzheimer disease. Peripheral clearance of Aβ may possibly also lower brain levels. Recent evidence suggested that hepatic clearance of Aβ42 is impaired in liver cirrhosis.

Oscillatory Correlates of Selective Restudy.

Prior behavioral work has shown that selective restudy of some studied items leaves recall of the other studied items unaffected when lag between study and restudy is short, but improves recall of the other items when lag is prolonged. The beneficial effect has been attributed to context retrieval, assuming that selective restudy reactivates the context at study and thus provides a retrieval cue for the other items (Bäuml, 2019). Here the results of two experiments are reported, in each of which subjects studied a list of items and then, after a short 2-min or a prolonged 10-min lag, restudied some of the list items.

List-method directed forgetting: Do critical findings generalize from short to long retention intervals?

People can purposefully forget information that has become irrelevant, as is demonstrated in list-method directed forgetting (LMDF). In this task, participants are cued to intentionally forget an already studied list (list 1) before encoding a second list (list 2); this induces forgetting of the first-list items. Most research on LMDF has been conducted with short retention intervals, but very recent studies indicate that such directed forgetting can be lasting.

The Incidence of Fractures Among the Adult Population of Germany–an Analysis From 2009 through 2019.

Background: Detailed analyses of epidemiological data on fractures are an impor - tant resource for persons and institutions providing health care services, as they yield information on the effects of current treatment strategies and on the need for preventive measures. The epidemiology of fractures in Germany, however, is unknown. The goal of this study is to determine the nationwide fracture burden from 2009 through 2019, as a function of anatomical site, age, and sex.

Implementation, relevance, and virtual adaptation of neuro-oncological tumor boards during the COVID-19 pandemic: a nationwide provider survey.

Purpose: Neuro-oncology tumor boards (NTBs) hold an established function in cancer care as multidisciplinary tumor boards. However, NTBs predominantly exist at academic and/or specialized centers. In addition to increasing centralization throughout the healthcare system, changes due to the COVID-19 pandemic have arguably resulted in advantages by conducting clinical meetings virtually.

Prophylaxis and treatment of influenza: options, antiviral susceptibility, and existing recommendations.

Influenza viruses of types A and B attack 5-10% of adults and 20-30% of children, thereby causing millions of acute respiratory infections in Germany annually. A significant number of these infections are associated with complications such as pneumonia and bacterial superinfections that need hospitalization and might lead to death. In addition to vaccines, drugs were developed that might support influenza prevention and that can be used to treat influenza patients.

Evaluation of comprehensiveness and reliability of electronic health records concerning resuscitation efforts within academic intensive care units: a retrospective chart analysis.

Background: According to the literature, the validity and reliability of medical documentation concerning episodes of cardiopulmonary resuscitation (CPR) is suboptimal. However, little is known about documentation quality of CPR efforts during intensive care unit (ICU) stays in electronic patient data management systems (PDMS). This study analyses the reliability of CPR-related medical documentation within the ICU PDMS.