10 results match your criteria: "Reference Center for Oral and Dental Rare Diseases[Affiliation]"

Root resorptions induced by genetic disorders: A systematic review.

Oral Dis

September 2024

Reference Center for Oral and Dental Rare Diseases, APHP, ORARES, Rothschild Hospital, Paris, France.

Objectives: Root resorption in permanent teeth is a common pathological process that often follows dental trauma or orthodontic treatment. More rarely, root resorption is a feature of genetic disorders and can help with diagnosis. Thus, the present review aims to determine which genetic disorders could induce pathological root resorptions and thus which mutated genes could be associated with them.

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[Oral mesenchymal cells, a specific niche, from development to regeneration].

Med Sci (Paris)

January 2024

Centre de recherche des Cordeliers, UMRS 1138, Molecular Oral Pathophysiology Lab, université Paris Cité, Inserm, Sorbonne université, Paris, France - Université Paris Cité, UFR odontologie, département de biologie orale, Paris, France - Reference center for oral and dental rare diseases, ORARES, Odontology department, hôpital Rothschild, APHP, Paris, France.

Oral buccal tissues, including bone and mucosa, have unique properties. Oral mucosal fibroblasts and jaw osteoblasts, both derived from Cranial Neural Crest cells, play a key role in healing and repair. These cells express a specific repertoire of genes with their regenerative properties, but also craniofacial diseases.

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Replacement of missing lateral incisors for patients with cleft lip and palate: A decision-making tree based on a systematic review of the literature.

J Prosthet Dent

September 2023

Associate Professor, Department of Periodontology, U.F.R. of Odontology, Université Paris Cité, Reference Center for Oral and Dental Rare Diseases (O-Rares), Rothschild Hospital AP-HP, Paris, France; Centre de Recherche des Cordeliers, Laboratory of Molecular Oral Physiopathology, Paris, France; and Adjunct Assistant Professor, Loma Linda University School of Dentistry, Department of Periodontology, Loma Linda, Calif.. Electronic address:

Statement Of Problem: Cleft lip and palate are the most frequent congenital anomalies of the face and are often linked with lateral incisor agenesis. The therapeutic decision on whether and how to replace the lateral incisors is not straightforward, and a decision-making tree is needed.

Purpose: The purpose of this systematic review was to evaluate the available literature reporting on treatments for the replacement of missing lateral incisors in cleft areas.

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Role of periosteum during healing of alveolar critical size bone defects in the mandible: a pilot study.

Clin Oral Investig

August 2023

Centre de Recherche Des Cordeliers, UMRS 1138, Molecular Oral Pathophysiology, Université Paris Cité, INSERM, Sorbonne Université, Paris, France.

Article Synopsis
  • - This study aims to establish a standard critical size defect (CSD) model for studying bone regeneration in the alveolar bone of Aachen minipigs, focusing on the role of the periosteum in bone healing.
  • - Three minipigs underwent a surgical procedure where one side preserved the periosteum and the other removed it, followed by various imaging and histological analyses to assess bone healing.
  • - Results indicated that bone healing was inadequate in both conditions, with significantly worse healing noted when the periosteum was absent, reinforcing the importance of this tissue in bone regeneration processes.
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Objective: This study aims to (1) assess the efficacy of a face-to-face emergency protocol in children and adults and (2) measure the efficacies of prediagnosis at the triage level and clinical diagnosis at the emergency department level during the COVID-19 pandemic.

Methods: A triage protocol was applied for patients at the entry of the Rothschild Hospital (AP-HP) between March 18th and May 11th, 2020. First, patients underwent a triage based on self-reported symptoms.

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Article Synopsis
  • Oral mucosal lesions are frequent in kids and can signal various infections, but diagnosing them can be tough for pediatricians and dentists.
  • The authors created a decision tree to help practitioners identify common viral, bacterial, and fungal diseases based on oral lesions in children.
  • They reviewed 42 conditions and compiled details about infection mechanisms, types of lesions, symptoms, and prevalence, focusing on the diseases most common in Europe and the U.S.
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Oral Phenotype of Singleton-Merten Syndrome: A Systematic Review Illustrated With a Case Report.

Front Genet

June 2022

Centre de Recherche des Cordeliers, UMRS 1138, Molecular Oral Pathophysiology, Université de Paris, INSERM, Sorbonne Université, Paris, France.

Singleton-Merten syndrome type 1 (SGMRT1) is a rare autosomal dominant disorder caused by variations with blood vessel calcifications, teeth anomalies, and bone defects. We aimed to summarize the oral findings in SGMRT1 through a systematic review of the literature and to describe the phenotype of a 10-year-old patient with SGMRT1 diagnosis. A total of 20 patients were described in the literature, in nine articles.

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Methodology: Gingival conditions and tooth sensitivity of young patients with amelogenesis imperfecta lack in depth studies. This case-control study aimed to compare (1) the gingival inflammation, the presence of enamel defects, and tooth sensitivity in young patients with and without amelogenesis imperfecta and (2) to investigate if any difference exists between subtypes of amelogenesis imperfecta. We compared forty-two participants with amelogenesis imperfecta with forty-two controls matched for age, gender, and the number of examined sites.

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Disrupted Iron Storage in Dental Fluorosis.

J Dent Res

August 2019

1 Centre de Recherche des Cordeliers, INSERM UMRS 1138, Université de Paris, Sorbonne Université, Laboratory of Molecular Oral Pathophysiology, Paris, France.

Enamel formation and quality are dependent on environmental conditions, including exposure to fluoride, which is a widespread natural element. Fluoride is routinely used to prevent caries. However, when absorbed in excess, fluoride may also lead to altered enamel structural properties associated with enamel gene expression modulations.

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Translation and cross-cultural validation of the French version of the Sleep-Related Breathing Disorder scale of the Pediatric Sleep Questionnaire.

Sleep Med

June 2019

Paris Diderot University, Sorbonne Paris Cité, Paris, France; Reference Center for Oral and Dental Rare Diseases, Rothschild Hospital, AP-HP, Paris, France; Molecular and Physiopathological Bases of Osteochondrodysplasia, Imagine Institute, UMR-S1163, Paris, France.

Background: Sleep-disordered breathing (SDB), including obstructive sleep apnea syndrome, is often underestimated because it requires a burdensome test (ie, polysomnography) to ensure diagnosis. To improve polysomnography referral, it is of utmost importance to validate efficient alternative screening tools. This study aimed to provide a translation and a cross-cultural validation of the Pediatric Sleep Questionnaire (PSQ) into French to obtain an easy-to-use and reliable screening tool.

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