1 results match your criteria: "Reference Center for Endocrine Growth and Developmental Diseases[Affiliation]"
High prevalence of syndromic disorders in patients with non-isolated central precocious puberty.
Eur J Endocrinol
December 2018
Assistance Publique-Hôpitaux de Paris, Robert Debré University Hospital, Endocrinology-Diabetology Department, Reference Center for Endocrine Growth and Developmental Diseases, Paris, France.
Article Synopsis
- The study focuses on non-idiopathic central precocious puberty (CPP) caused by hypothalamic lesions or associated with genetic syndromes, using MRI for assessment.
- Over 11.5 years, 63 children were identified, with 45% showing hypothalamic lesions such as hamartomas and optic gliomas, while 55% had non-structural lesions related to conditions like narcolepsy and autism spectrum disorders.
- The results highlight a significant number of non-idiopathic CPP cases without obvious hypothalamic lesions, suggesting the need for further research into the underlying causes and mechanisms of CPP in these patients.