2 results match your criteria: "Redeemer's University Nigeria[Affiliation]"
A prospective, multi-site, cohort study to estimate incidence of infection and disease due to Lassa fever virus in West African countries (the Enable Lassa research programme)-Study protocol.
PLoS One
April 2023
Fondation pour la Recherche Scientifique (FORS), Cotonou, Bénin.
Background: Lassa fever (LF), a haemorrhagic illness caused by the Lassa fever virus (LASV), is endemic in West Africa and causes 5000 fatalities every year. The true prevalence and incidence rates of LF are unknown as infections are often asymptomatic, clinical presentations are varied, and surveillance systems are not robust. The aim of the Enable Lassa research programme is to estimate the incidences of LASV infection and LF disease in five West African countries.
View Article and Find Full Text PDFHumoral and cellular immune responses to Lassa fever virus in Lassa fever survivors and their exposed contacts in Southern Nigeria.
Sci Rep
December 2022
The Africa Centre of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University Nigeria, Ede, Nigeria.
Article Synopsis
- The study investigates the immune responses in Lassa fever (LF) survivors and their contacts in Nigeria to understand natural protection and inform vaccine development.
- It finds that while both groups show similar T cell and antibody responses, neutralizing antibodies are predominantly present in LF survivors and provide cross-reactivity against various LASV strains.
- The research also highlights that immune responses diminish over time, suggesting potential vaccine targets in specific areas of the LASV Glycoprotein and Nucleoprotein for future clinical trials.