Activity of CDK4/6 inhibitors and parameters affecting survival in elderly patients in age-subgroups: Turkish Oncology Group (TOG) retrospective study.

Highly selective inhibitors of cyclin-dependent kinase 4 and 6 (CDK4/6is) have emerged as a standart of care for first- and second-line therapies in combination with endocrine therapy (ET) for HR+/HER2- metastatic breast cancer (MBC) patients. It has been reported that combination therapy is more effective than ET alone and is safe in elderly patients as well as young patients. Nevertheless, elderly and very old patients with HR+/HER2-MBC treated with CDK4/6 inhibitor (CDK4/6i) combinations are relatively underrepresented in randomized controlled trials.

Evaluation of heart rate variability, QT dispersion, and Tp-e interval in pediatric subclinical hypothyroidism.

Background: Clinical effects of subclinical hypothyroidism are not clearly understood. This study aims to investigate the effects of subclinical hypothyroidism (SH) on cardiac autonomic and conduction systems in children.

Methods: Forty-seven cases (25 female, 22 male) with SH aged between 3 and 17 years and 46 controls that were age, body mass index and sex matched, were included in the study.

Independent Relationship between Ankylosing Spondylitis and Presystolic Wave Detected on Echocardiography.

Objective: Ankylosing spondylitis (AS) is a persistent inflammatory disease affecting the axial skeleton which may lead to cardiovascular involvement. We examined the relationship between the presystolic wave (PW), which is frequently encountered in the evaluation of the left ventricular (LV) outflow tract, and AS.

Methods: The study included 117 consecutive patients with 73 of them being male.

The sharp edge of immunosuppressive treatments: infections.

Background And Aim: Different side effects, including infections, are encountered in patients receiving anticytokines used for the treatment of severe coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the infections and the effects of these infections that develop in this patient group.

Materials And Methods: This study included 208 patients who were followed-up with the diagnosis of severe COVID-19 in two different hospitals.

The development of point-of-care ultrasound (POCUS): Worldwide contributions and publication trends.

Purpose: Point-of-care ultrasound (POCUS) concept is widely used in both emergency medicine (EM) and intensive care medicine (ICM). This study aimed to analyze the scientific articles on POCUS published by statistical methods and to evaluate the subject holistically.

Methods: This study is bibliographical, descriptive, and analytical in nature.

Hepatitis B reactivation risk and physician awareness in rheumatological patients receiving anti-tumor necrosis factor-α treatment.

Objective: We aimed to evaluate the risk of hepatitis B virus reactivation in rheumatic patients using anti-tumor necrosis factor-alpha drugs and the awareness of physicians about hepatitis B virus reactivation.

Methods: Demographic characteristics, pre- and post-treatment hepatitis markers, and laboratory parameters of patients receiving anti-tumor necrosis factor-alpha therapy in our rheumatology clinic were retrospectively examined.

Results: A total of 448 patients, 240 (53.

February 6, Kahramanmaraş earthquakes and the disaster management algorithm of adult emergency medicine in Turkey: An experience review.

This compilation covers emergency medical management lessons from the February 6 Kahramanmaraş earthquakes. The objective is to review relevant literature on emergency services patient management, focusing on Koenig's 1996 Simple Triage and Rapid Treatment (START) and Secondary Assessment of Victim Endpoint (SAVE) frameworks. Establishing a comprehensive seismic and mass casualty incident (MCI) protocol chain is the goal.

Effect of tumor-infiltrating immune cells (mast cells, neutrophils and lymphocytes) on neoadjuvant chemotherapy response in breast carcinomas.

Introduction: Despite screening, the incidence of breast cancer is increasing worldwide. Neoadjuvant chemotherapy (NAC) response is one of the most important parameters taken into consideration in surgery, optimal adjuvant chemotherapy planning and prognosis prediction. Research on predictive markers for the response to NAC is still ongoing.

Radiomics-based machine learning in the differentiation of benign and malignant bowel wall thickening radiomics in bowel wall thickening.

Purpose: To distinguish malignant and benign bowel wall thickening (BWT) by using computed tomography (CT) texture features based on machine learning (ML) models and to compare its success with the clinical model and combined model.

Methods: One hundred twenty-two patients with BWT identified on contrast-enhanced abdominal CT and underwent colonoscopy were included in this retrospective study. Texture features were extracted from CT images using LifeX software.

Effect of a cervical collar on optic nerve sheath diameter in trauma patients.

Background: As advocated in advanced trauma life support and prehospital trauma life support protocols, cervical immobilization is applied until cervical spine injury is excluded. This study aimed to show the difference in optic nerve sheath diameter (ONSD) between patients with and without a cervical collar using computed tomography (CT).

Methods: This was a single-center, retrospective study examining trauma patients who presented to the emergency department between January 1, 2021, and December 31, 2021.

The accuracy of the Hounsfield unit in pulmonary embolism diagnostics.

Objective: Pulmonary embolism (PE) is a vascular disease that is most frequently diagnosed using the radiological imaging technique computed tomography pulmonary angiography (CTPA). In this study, we aimed to demonstrate the diagnostic accuracy of the Hounsfield unit (HU) for PE based on the hypothesis that acute thrombosis causes an increase in HU value on CT.

Methods: This research was a single-center, retrospective study.

The utility of NIRS in follow-up of patients with acute ischaemic stroke treated with IV thrombolysis and mechanical thrombectomy in the emergency department.

Revascularization treatments (IV thrombolysis, mechanical thrombectomy) related to ischemic stroke have developed in recent years. With devices such as NIRS, non-invasive monitoring of treatment efficacy is provided. In this study, we aimed to use near-infrared spectroscopy (NIRS) as an objective monitoring method to see the effect of intravenous (IV) thrombolysis or mechanical thrombectomy treatments applied for cerebral oxygenation in patients with acute ischemic stroke.

Comparison of Ticagrelor and Clopidogrel in Patients With Acute Coronary Syndrome at High Bleeding or Ischemic Risk.

Current guidelines recommend individualizing the choice and duration of P2Y inhibitor therapy based on the trade-off between bleeding and ischemic risk. However, whether a potent P2Y inhibitor (ticagrelor) or a less potent one (clopidogrel) is more appropriate in patients with acute coronary syndrome (ACS) in the setting of high bleeding or ischemic risk is not clear. The study aimed to compare the clinical outcomes of clopidogrel and ticagrelor in patients with ACS at high bleeding or ischemic risk.

Preoperative assessment of grade, T stage, and lymph node involvement: machine learning-based CT texture analysis in colon cancer.

Purpose: To investigate whether texture analysis of primary colonic mass in preoperative abdominal computed tomography (CT) scans of patients diagnosed with colon cancer could predict tumor grade, T stage, and lymph node involvement using machine learning (ML) algorithms.

Materials And Methods: This retrospective study included 73 patients diagnosed with colon cancer. Texture features were extracted from contrast-enhanced CT images using LifeX software.

Inr tracking with face-to-face and phone app.

Background: Warfarin has a narrow therapeutic window. Maintaining the patient's international normalized ratio (INR) within a predefined therapeutic range is one of the main challenges of warfarin treatment. This study aimed to compare the INR values of patients followed by face-to-face and telephone applications.

Brain computed tomography in centenarians presenting to the emergency department: is age an indication to CT scan?

Objective: This study aimed to explore the relationship between admission complaints and brain computed tomography (CT) examinations. Also, we evaluated the relationship between age and CT scan results in centenarians admitted to the emergency department for non-traumatic reasons.

Patients And Methods: This study was a retrospective analysis of patients aged 100 years and older who presented to the tertiary hospital emergency department for non-traumatic reasons between 2012 and 2021.

Can Frequent Toothbrushing Reduce the Risk of Cirrhosis among Patients with Nonalcoholic Fatty Liver Disease? Hints from a Registry-Based Study.

Introduction: While poor oral hygiene has been previously associated with an increased risk of nonalcoholic fatty liver disease (NAFLD), its association with hepatic fibrosis remains unclear. Here, we sought to analyze if toothbrushing frequency, an easy-to-assess indicator of oral health habits, would be associated with liver stiffness measurement (LSM) by transient elastography (TE) in patients with an established diagnosis of NAFLD.

Methods: In this registry-based study, LSM was measured in 1,156 patients with NAFLD and analyzed in relation to the self-reported daily frequency of toothbrushing.

Expression of cytotoxic T lymphocyte-associated antigen 4, CD44, and E-cadherin in the microenvironment of breast carcinomas.

Objective: The expression of cytotoxic T lymphocyte-associated antigen 4, E-cadherin, and CD44 in the area of tumor budding was investigated in breast carcinomas in our study.

Methods: Tumor budding was counted at the invasive margins in 179 breast carcinomas. To understand the microenvironment of tumor budding, we examined the expression status of the immune checkpoint molecules such as cytotoxic T lymphocyte-associated antigen 4, E-cadherin, and CD44.

The relationship between ascending aortic diameter with left atrial functions and left ventricular mass index in a population with normal left ventricular systolic function.

Aim: Ascending aortic dilatation is a common clinical issue. In the present study, we aimed to evaluate the relationship between ascending aortic diameter with left ventricular (LV) and left atrial (LA) functions, and LV mass index (LVMI) in a population with normal LV systolic function.

Methods: A total of 127 healthy participants with normal LV systolic function took part in the study.

The role of repeated extended FAST in patients with stable blunt thoracoabdominal trauma.

Background: Thoracic and abdominal computed tomography scans are widely used modalities for trauma patients in emergency department (ED). However, alternative diagnostic and follow-up tools are also needed, due to limitations such as high cost and exces-sive radiation exposure. This study aimed to investigate the utility of repeated extended focused abdominal sonography for trauma (rE-FAST) performed by the emergency physician in patients with stable blunt thoracoabdominal trauma.