1,189 results match your criteria: "Reagan UCLA Medical Center[Affiliation]"

Expanding the repertoire of F-labeled PET MPI radiotracers.

J Nucl Cardiol

April 2024

Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, USA; Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, USA; Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA; Veterans Affairs West Los Angeles Medical Center, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, USA; Molecular Biology Institute, University of California, Los Angeles, USA; California NanoSystems Institute, University of California, Los Angeles, USA. Electronic address:

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Article Synopsis
  • Intracerebral hemorrhage (ICH) is a highly lethal form of stroke, especially in patients on anticoagulants, prompting the development of new reversal strategies for anticoagulation.
  • This study analyzes data from nearly 10,000 ICH patients treated at US hospitals to see how the timing of treatment (door-to-treatment or DTT times) affects patient outcomes after receiving reversal interventions.
  • Results showed that a large portion of patients received reversal therapy, and specific DTT times were correlated with inpatient mortality and functional status, highlighting the importance of timely intervention in improving outcomes.
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[This corrects the article DOI: 10.3389/fncel.2023.

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Evaluating and Enhancing Nursing Caregiver Well-being Using a Systematic Approach.

J Nurs Adm

February 2024

Authors Affiliations : Executive Director-Retired (Dr Galuska), Nursing Practice, Education and Research; Interim Executive Director (Dr Phillips), Nursing Practice, Education and Research; Nursing Professional Development Specialist (Anderson); and Senior Nurse Scientist (Dr Miller), Center for Nursing Excellence, UCLA Health, Los Angeles, California; Clinical Nurse (Meyer and Lor), Ronald Reagan UCLA Medical Center, Los Angeles, California; and Nursing Practice Outcomes and Magnet Coordinator (Mahnovski), Resnick Neuropsychiatric Hospital at UCLA, Los Angeles, California.

Objective: The aims of this study were to evaluate nursing caregiver well-being and identify interventions for improving well-being and practice environments.

Background: Healthcare worker well-being and burnout command increasing attention in the wake of the pandemic. Experts recommend utilization of validated measurements to assess burnout, well-being, and contributing factors.

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Background: Randomized trials have recently evaluated the non-inferiority of direct thrombectomy versus intravenous thrombolysis (IVT) followed by endovascular therapy in anterior circulation large vessel occlusion (LVO) stroke in patients eligible for IVT within 4.5 h from stroke onset with controversial results. We aimed to assess the effect of IVT on the clinical outcome of mechanical thrombectomy (MT) in the RESILIENT trial.

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Reply to the Editor- Cardiac denervation and its consequences in heart disease.

Heart Rhythm

April 2024

UCLA Cardiac Arrhythmia Center & Neurocardiology Research Program of Excellence, Ronald Reagan UCLA Medical Center, Los Angeles, California.

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Article Synopsis
  • Lymph node metastases from oral cavity cancers are common, but there's debate over the best surgical approach for neck management in these patients, focusing on the necessary dissection extent.
  • Extensive research provides a foundation for evidence-based treatment strategies, highlighting the need for preoperative staging and the importance of neck dissection even when lymph nodes appear clinically negative.
  • Recommendations emphasize proper specimen handling and achieving a lymph node yield of 18 or more, with sentinel lymph node biopsy being an option for certain cases within experienced teams.
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Characterization of cerebellar amyloid-β deposits in Alzheimer disease.

J Neuropathol Exp Neurol

January 2024

Section of Neuropathology, Department of Pathology and Laboratory Medicine, Ronald Reagan UCLA Medical Center and David Geffen School of Medicine, University of California, Los Angeles, California, USA.

Article Synopsis
  • Cerebellar amyloid-β (Aβ) plaques play a crucial role in diagnosing Alzheimer disease (AD) and were studied for their characteristics in 73 cases with specific A3 scores in the ABC criteria.
  • Over 85% of these cases showed significant parenchymal Aβ-42 staining, particularly in those classified as Braak stage V-VI/B3, indicating a strong correlation between Aβ deposits and disease severity.
  • The study also found that the presence of Aβ-42 in the Purkinje cell layer was linked to neuronal damage, with varying morphologies of the plaques noted, and a significant occurrence of cerebral amyloid angiopathy (CAA) in both parenchymal and leptomeningeal
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Background: Secondary prevention of ischemic stroke (IS) requires adequate diagnostic evaluation to identify the likely etiologic subtype. We describe hospital-level variability in diagnostic testing and IS subtyping in a large nationwide registry.

Methods And Results: We used the GWTG-Stroke (Get With The Guidelines-Stroke) registry to identify patients hospitalized with a diagnosis of acute IS at 1906 hospitals between January 1, 2016, and September 30, 2017.

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Background: Individuals with acute decompensated heart failure (ADHF) have a varying response to diuretic therapy. Strategies for the early identification of low diuretic efficiency to inform decongestion therapies are lacking.

Objectives: The authors sought to develop and externally validate a machine learning-based phenomapping approach and integer-based diuresis score to identify patients with low diuretic efficiency.

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Patient Outcomes of Definitive Diverticular Hemorrhage After Colonoscopic, Medical, Surgical, or Embolization Treatment.

Dig Dis Sci

February 2024

VA Hemostasis Research Unit and Division of Digestive Diseases, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.

Background: There are few reports of clinical outcomes or the natural history of definitive diverticular hemorrhage (DDH).

Aims: To describe 1-year clinical outcomes of patients with documented DDH treated with colonoscopic hemostasis, angioembolization, surgery, or medical treatment.

Methods: DDH was diagnosed when active bleeding or other stigmata of hemorrhage were found in a colonic diverticulum during urgent colonoscopy or extravasation on angiography or red blood cell (RBC) scanning.

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Article Synopsis
  • Researchers studied gene expression changes in hearts after transplants to understand why some fail while others don’t.
  • They found that heart dysfunction is linked to reduced expression of typical heart genes, inflammation, and decreased matrix genes, which are crucial for heart structure.
  • Genetic factors that predict survival within three years after a biopsy indicate that injury and microcirculation issues, rather than rejection alone, mainly determine the chances of graft failure.
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Background: Intracranial atherosclerotic disease (ICAD) significantly contributes to ischemic stroke, especially among Asian populations. Large vessel occlusion (LVO) due to underlying ICAD accounts for 15-35% of acute ischemic stroke cases requiring endovascular therapy. However, the successful recanalization rate of ICAD-related LVO remains lower.

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Background: Acute myocardial infarction complicated by cardiogenic shock (AMI-CS) is associated with significant morbidity and mortality. Mechanical circulatory support (MCS) devices increase systemic blood pressure and end organ perfusion while reducing cardiac filling pressures.

Methods And Results: The National Cardiogenic Shock Initiative (NCT03677180) is a single-arm, multicenter study.

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Hyperleukocytosis, a white blood cell count greater than 100,000/mcl, can be associated with the following three primary oncologic emergencies: leukostasis, disseminated intravascular coagulation, and tumor lysis syndrome. Th.

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A 55-year-old man with renal cell carcinoma extending into the renal vein/inferior vena cava (status post nephrectomy and inferior vena cava thrombectomy, pT3bN0M0), and perioperative pulmonary bland thromboembolism (resolved with 3-month of anticoagulation), followed by 3.5 years of complete remission, developed new incidental pulmonary arterial filling defects on a surveillance CT examination (asymptomatic, normal d -dimer, no deep vein thrombosis). Despite anticoagulation, the filling defects not only persisted but also demonstrated intense FDG activity on a restaging PET/CT performed 4 months later for new pulmonary oligometastasis.

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Introduction: Hepatocellular carcinoma (HCC) is the most common primary liver cancer and is the fourth-leading cause of all cancer-related deaths around the world. Liver transplantation, surgery, and local ablation are curative therapies for early-stage HCC. However, post-treatment outcomes can vary based on histopathologic stage.

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Background: DuraMatrix-Onlay Plus is a collagen dura membrane derived from purified bovine Achilles tendon. The matrix provides a scaffold for collagen synthesis and is intended to be used as an onlay without the need for dural sutures. The study aims to describe our experience with 33 consecutive patients who underwent a duraplasty procedure using the novel DuraMatrix-Onlay Plus collagen dura membrane.

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Fractional flow reserve (FFR) and nonhyperemic pressure ratios (NHPRs) provide an important clinical tool to evaluate the hemodynamic significance of coronary lesions. However, these indices have major limitations. As these indices are meant to be surrogates of coronary flow, clinical scenarios such as aortic stenosis (with increased end-systolic and end-diastolic pressures) or atrial fibrillation (with significant beat-to-beat cardiac output variability) can have significant effect on the accuracy and reliability of these hemodynamic indices.

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Background: Non-variceal upper gastrointestinal bleeding (NVUGIB) is a common medical problem worldwide. Independent endoscopic risk factors for rebleeding and mortality of NVUGIB that are treatable are stigmata of recent hemorrhage (SRH) and arterial blood flow underneath SRH. The specific aims of this paper are to describe the importance of arterial blood flow detection for risk stratification and as a guide to definitive hemostasis of severe NVUGIB.

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Background There is a paucity of large-scale epidemiological studies on the link between cardiac autonomic neuropathy (CAN) and the risk of silent myocardial infarction (SMI) in type 2 diabetes. We evaluated the association between CAN and the risk of SMI in a large sample of adults with type 2 diabetes. Methods and Results Participants with type 2 diabetes from the ACCORD (Action to Control Cardiovascular Risk in Diabetes) study without atherosclerotic cardiovascular disease at baseline were included.

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